Abstract: The invention involves condensation of various derivatives of cyclic alkene alcohols of Formula II or Formula III where, R1 is alkyl, aryl, alkyl aryl or heterocyclic carbamoyl. R2 is either R1 as mentioned earlier or an acyl group, —C(?O)—R3 where, R3 is selected from a group comprising (subst)C1-C12 alkyl, (subst)aryl, alkyl aryl with olivetol to get (?)-trans-?9-tetrahydrocannabinol (also known as Dronabinol, Formula I). The process disclosed provides high purity of dronabinol at crude stage making it easy for purification.
Abstract: The present invention relates to method of production of optically active chiral amine from alpha hydroxy ketone using enzyme transaminase as the biocatalyst. In particular the present invention relates to production of (1R, 2S)-Norephedrine and its salts from R-Phenylacetylcarbinol (R-PAC) by employing S-transaminase as the biocatalyst and Isopropylamine as the amine donor.