Patents Assigned to EMBL
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Patent number: 10908403Abstract: A microscope is described, having an illumination light path for illuminating a sample or object and a viewing light path for viewing the sample. The microscope includes an illumination light path focussing arrangement in the illumination light path, defining a substantially two-dimensional sample or object illumination region extending along an illumination direction of the illumination light path and transversely thereto. The microscope further includes an illumination region-confining device in the illumination light path for selectively illuminating a portion of the substantially two-dimensional object illumination region, wherein the portion of the substantially two-dimensional object illumination region is confined at least in the illumination direction and/or in the direction transversely thereto.Type: GrantFiled: February 13, 2012Date of Patent: February 2, 2021Assignee: EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL)Inventors: Michael Knop, Malte Wachsmuth, Jérémie Capoulade
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Patent number: 10698192Abstract: A microscopy system provides for scanning a sample by a microscope, which is at least in part electrically or electronically controllable and in which a plurality of images or digital images are generatable in a scanning operation at different times and/or different locations of the sample. The microscopy system includes a control computer configured to control the microscope, as well as further computers that are integratable into the microscopy system such that an adaptation of the microscopy system is possible dynamically and/or during the scanning operation using at least one of the further computers.Type: GrantFiled: March 14, 2019Date of Patent: June 30, 2020Assignees: LEICA MICROSYSTEMS CMS GMBH, EMBL EUROPEAN MOLECULAR BIOLOGY LABORATORYInventors: Frank Sieckmann, Urban Liebel
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Patent number: 10481374Abstract: A method for scanning a sample using an electrically or electronically controllable microscope includes performing a continuous scanning of the sample so as to repeatedly generate a plurality of images of the sample, each of the plurality of images corresponding to a different time, the microscope being controlled via a control computer during the scanning. The plurality of images are analyzed using at least one second computer connected via a network, wherein the at least one second computer is configured to classify each of the plurality of images as one of interesting and non-interesting while the continuous scanning of the sample with the microscope continues. The continuous scanning of the sample is automatically influenced based on the classifying of the images performed by the at least one second computer.Type: GrantFiled: February 7, 2017Date of Patent: November 19, 2019Assignees: LEICA MICROSYSTEMS CMS GMBH, EMBL EUROPEAN MOLECULAR BIOLOGY LABORATORYInventors: Frank Sieckmann, Urban Liebel
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Publication number: 20190154552Abstract: The present disclosure teaches an apparatus and a method for providing one or more substance liquids to a microfluidic channel network. The microfluidic apparatus includes valves for switching the one or more substance liquids to a microfluidic channel network. The apparatus can be used to generate a sequence of the one or more substance liquids as individual droplets in an immiscible separation liquid wherein individual ones of the sequence of droplets are located between the separation liquid.Type: ApplicationFiled: January 9, 2019Publication date: May 23, 2019Applicant: EMBLInventors: Christoph Merten, Ramesh Utharala
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Patent number: 10215671Abstract: An apparatus and a method for providing one or more substance liquids to a microfluidic channel network (30). The microfluidic apparatus includes valves for switching the one or more substance liquids to a microfluidic channel network (30). The apparatus can be used to generate a sequence of the one or more substance liquids as individual droplets in an immiscible separation liquid wherein individual ones of the sequence of droplets are located between the separation liquid.Type: GrantFiled: October 6, 2017Date of Patent: February 26, 2019Assignee: EMBLInventors: Christoph Merten, Ramesh Utharala
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Publication number: 20180300791Abstract: The present invention relates to a method and system for recommending fitting footwear. The method includes receiving, by a footwear recommendation system, a plurality of still images associated with at least one foot of a user. At least one of the still images includes information of a standard reference object placed proximate to the at least one foot of the user. The still images are processed to generate a digital geometric profile representing the at least one foot of the user. Set of foot measurements is extracted from the digital geometric profile to classify the digital geometric profile into foot type data. The digital geometric profile and the foot type data together are stored as a foot geometric profile. At least one fitting footwear is identified for the user based on the foot geometric profile. Moreover, display of the at least one fitting footwear on the user device is initiated.Type: ApplicationFiled: May 18, 2016Publication date: October 18, 2018Applicant: EMBL RETAIL INC.Inventors: Anand GANESAN, Shabari RAJE, Mukul KELKAR, Ponnuswamy NATHAN SENTHIL
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Publication number: 20180095014Abstract: An apparatus and a method for providing one or more substance liquids to a microfluidic channel network (30). The microfluidic apparatus includes valves for switching the one or more substance liquids to a microfluidic channel network (30). The apparatus can be used to generate a sequence of the one or more substance liquids as individual droplets in an immiscible separation liquid wherein individual ones of the sequence of droplets are located between the separation liquid.Type: ApplicationFiled: October 6, 2017Publication date: April 5, 2018Applicant: EMBLInventors: Christoph Merten, Ramesh Utharala
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Publication number: 20180088304Abstract: The invention relates to a microscope in which a layer of the sample is illuminated by a plurality of thin strips of light (11) passed through a grid (34) and the sample is viewed (5) perpendicular to the plane of the strips of light. To record the image, the object (4) is displaced through the strips of light (11). At least three different images of the objects (4) are made at different phase angles. The images can be combined to form a single combined image.Type: ApplicationFiled: November 20, 2017Publication date: March 29, 2018Applicant: Europaeisches Laboratorium Fuer Molekularbiologie (EMBL)Inventor: Ernst H.K. Stelzer
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Patent number: 9890368Abstract: The present invention relates to polypeptide fragments comprising an amino-terminal fragment of the PA subunit of a viral RNA-dependent RNA polymerase or variants thereof possessing endonuclease activity, wherein said PA subunit is from a virus belonging to the Orthomyxoviridae family. This invention also relates to (i) crystals of the polypeptide fragments which are suitable for structure determination of said polypeptide fragments using X-ray crystallography and (ii) computational methods using the structural coordinates of said polypeptide to screen for and design compounds that modulate, preferably inhibit the endonucleolytically active site within the polypeptide fragment. In addition, this invention relates to methods identifying compounds that bind to the PA polypeptide fragments possessing endonuclease activity and preferably inhibit said endonucleolytic activity, preferably in a high throughput setting.Type: GrantFiled: October 21, 2014Date of Patent: February 13, 2018Assignees: European Molecular Biology Laboratory (EMBL), Centre National de la Recherche Scientifique, Universite Grenoble AlpesInventors: Denis Bouvier, Thibaut Crepin, Rob Ruigrok, Aelxander Dias, Stephen Cusack
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Patent number: 9857577Abstract: A microscope and imaging method in which a layer of the sample is illuminated by a thin strip of light and the sample is viewed perpendicular to the plane of the strip of light. The depth of the strip of light thus essentially determines the depth of focus of the system. To record the image, the object is displaced through the strip of light, which remains fixed in relation to the detector, and fluorescent and/or diffused light is captured by a planar detector. Objects that absorb or diffuse a large amount of light are viewed from several spatial directions. The three-dimensional images, which are captured from each direction can be combined retrospectively to form one image, in which the data is weighted according to its resolution. The resolution of the combined image is then dominated by the lateral resolution of the individual images.Type: GrantFiled: January 22, 2013Date of Patent: January 2, 2018Assignee: European Molecular Biology Laboratory (EMBL)Inventors: Ernst H. K. Stelzer, Sebastian Enders, Jan Huisken, Steffen Lindek, James H. Swoger
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Patent number: 9823455Abstract: The invention relates to a microscope in which a layer of the sample is illuminated by a plurality of thin strips of light (11) passed through a grid (34) and the sample is viewed (5) perpendicular to the plane of the strips of light. To record the image, the object (4) is displaced through the strips of light (11). At least three different images of the objects (4) are made at different phase angles. The images can be combined to form a single combined image.Type: GrantFiled: February 3, 2015Date of Patent: November 21, 2017Assignee: Europaeisches Laboratorium Fuer Molekularbiologie (EMBL)Inventor: Ernst H. K. Stelzer
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Patent number: 9810607Abstract: The present disclosure teaches an apparatus and a method for providing one or more substance liquids to a microfluidic channel network (30). The microfluidic apparatus includes valves for switching the one or more substance liquids to a microfluidic channel network (30). The apparatus can be used to generate a sequence of the one or more substance liquids as individual droplets in an immiscible separation liquid wherein individual ones of the sequence of droplets are located between the separation liquid.Type: GrantFiled: September 14, 2012Date of Patent: November 7, 2017Assignee: EMBLInventors: Christoph Merten, Ramesh Utharala
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Patent number: 9783794Abstract: The present invention relates to polypeptide fragments comprising an amino-terminal fragment of the PA subunit of a viral RNA-dependent RNA polymerase possessing endonuclease activity, wherein the PA subunit is from Influenza A 2009 pandemic H1N1 virus or is a variant thereof. This invention also relates to (i) crystals of the polypeptide fragments which are suitable for structure determination of the polypeptide fragments using X-ray crystallography and (ii) computational methods using the structural coordinates of the polypeptide to screen for and design compounds that modulate, preferably inhibit the endonucleolytically active site within the polypeptide fragment. In addition, this invention relates to methods of identifying compounds that bind to the PA polypeptide fragments possessing endonuclease activity and preferably inhibit the endonucleolytic activity, as well as the compounds themselves.Type: GrantFiled: June 26, 2015Date of Patent: October 10, 2017Assignee: European Molecular Biology Laboratory (EMBL)Inventors: Stephen Cusack, Eva Kowalinski, Chloe Zubieta
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Patent number: 9588329Abstract: A method for scanning a sample using an electrically or electronically controllable microscope, includes scanning the sample so as to generate a plurality of images of the sample, each of the plurality of images corresponding to at least one of a different region of the sample and a different time. The microscope is controlled via a control computer during the scanning. The plurality of images are analyzed using at least one second computer connected via a network. The plurality of images are classified and/or the scanning is influenced based on the analyzing.Type: GrantFiled: September 6, 2007Date of Patent: March 7, 2017Assignees: LEICA MICROSYSTEMS CMS GMBH, EMBL EUROPEAN MOLECULAR BIOLOGY LABORATORYInventors: Frank Sieckmann, Urban Liebel
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Publication number: 20160297763Abstract: The present invention relates to a compound having the general formula I, optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, which is useful in treating, ameloriating or preventing a viral disease. Furthermore, specific combination therapies are disclosed.Type: ApplicationFiled: April 6, 2016Publication date: October 13, 2016Applicants: F. HOFFMANN-LA ROCHE LTD, SAVIRA PHARMACEUTICALS GMBH, EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL)Inventors: Dirk CLASSEN-HOUBEN, Andrea WOLKERSTORFER, Oliver SZOLAR, Mark SMITH, Sung-Sau SO, Stephen CUSACK, Thierry LANGER, Bruno GIETHLEN, Christophe MORICE, Céline MICHAUT-SIMON, Chloe ZUBIETA
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Publication number: 20150309294Abstract: The invention relates to a microscope in which a layer of the sample is illuminated by a plurality of thin strips of light (11) passed through a grid (34) and the sample is viewed (5) perpendicular to the plane of the strips of light. To record the image, the object (4) is displaced through the strips of light (11). At least three different images of the objects (4) are made at different phase angles. The images can be combined to form a single combined image.Type: ApplicationFiled: February 3, 2015Publication date: October 29, 2015Applicant: Europaeisches Laboratorium Fuer Molekularbiologie (EMBL)Inventor: Ernst H.K. STELZER
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Publication number: 20150218539Abstract: The present invention relates to an activator of the calcineurin subunit A?1 isofomi (CnA?1) or of the C-terminal domain of the calcineurin subunit A?1 isofomi (CnA?1) for the production of a medicament for the modulation of myocardial growth without adversely affecting contractile function.Type: ApplicationFiled: August 16, 2013Publication date: August 6, 2015Applicant: EMBL EUROPEAN MOLECULAR BIOLOGY LABORATORYInventors: Enrique Lara Pezzi, Marina López Olaneta, Maria Villalba Orero, Jesús Gómez Salinero, Nadia Rosenthal
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Patent number: 9085514Abstract: The present invention relates to unnatural amino acids comprising a cyclooctynyl or trans-cyclooctenyl analog group and having formula (I) or an acid or base addition salt thereof. The invention also relates to the use of said unnatural amino acids, kits and processes for preparation of polypeptides that comprise one or more than one cyclooctynyl or trans-cyclooctenyl analog group. These polypeptides can be covalently modified by in vitro or in vivo reaction with compounds comprising an azide, nitrile oxide, nitrone, diazocarbonyl or 1,2,4,5-tetrazine group.Type: GrantFiled: February 3, 2012Date of Patent: July 21, 2015Assignee: EMBLInventors: Edward Lemke, Carsten Schultz, Tilman Plass, Sigrid Milles, Christine Koehler
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Publication number: 20150105315Abstract: The present invention relates to polypeptide fragments comprising an amino-terminal fragment of the PA subunit of a viral RNA-dependent RNA polymerase or variants thereof possessing endonuclease activity, wherein said PA subunit is from a virus belonging to the Orthomyxoviridae family. This invention also relates to (i) crystals of the polypeptide fragments which are suitable for structure determination of said polypeptide fragments using X-ray crystallography and (ii) computational methods using the structural coordinates of said polypeptide to screen for and design compounds that modulate, preferably inhibit the endonucleolytically active site within the polypeptide fragment. In addition, this invention relates to methods identifying compounds that bind to the PA polypeptide fragments possessing endonuclease activity and preferably inhibit said endonucleolytic activity, preferably in a high throughput setting.Type: ApplicationFiled: October 21, 2014Publication date: April 16, 2015Applicants: EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL), UNIVERSITY JOSEPH FOURIER FILIALE, Centre National de la Recherche Scientifique - Direction de la Politique IndustrielleInventors: Denis Bouvier, Thibaut Crepin, Rob Ruigrok, Alexander Dias, Stephen Cusack
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Patent number: 8970950Abstract: The invention relates to a microscope in which a layer of the sample is illuminated by a plurality of thin strips of light (11) passed through a grid (34) and the sample is viewed (5) perpendicular to the plane of the strips of light. To record the image, the object (4) is displaced through the strips of light (11). At least three different images of the objects (4) are made at different phase angles. The images can be combined to form a single combined image.Type: GrantFiled: November 3, 2006Date of Patent: March 3, 2015Assignee: Europaeisches Laboratorium fuer Molekularbiologie (Embl)Inventor: Ernst H. K. Stelzer