Patents Assigned to EMBL European Molecular Biology Laboratory
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Patent number: 10698192Abstract: A microscopy system provides for scanning a sample by a microscope, which is at least in part electrically or electronically controllable and in which a plurality of images or digital images are generatable in a scanning operation at different times and/or different locations of the sample. The microscopy system includes a control computer configured to control the microscope, as well as further computers that are integratable into the microscopy system such that an adaptation of the microscopy system is possible dynamically and/or during the scanning operation using at least one of the further computers.Type: GrantFiled: March 14, 2019Date of Patent: June 30, 2020Assignees: LEICA MICROSYSTEMS CMS GMBH, EMBL EUROPEAN MOLECULAR BIOLOGY LABORATORYInventors: Frank Sieckmann, Urban Liebel
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Patent number: 10481374Abstract: A method for scanning a sample using an electrically or electronically controllable microscope includes performing a continuous scanning of the sample so as to repeatedly generate a plurality of images of the sample, each of the plurality of images corresponding to a different time, the microscope being controlled via a control computer during the scanning. The plurality of images are analyzed using at least one second computer connected via a network, wherein the at least one second computer is configured to classify each of the plurality of images as one of interesting and non-interesting while the continuous scanning of the sample with the microscope continues. The continuous scanning of the sample is automatically influenced based on the classifying of the images performed by the at least one second computer.Type: GrantFiled: February 7, 2017Date of Patent: November 19, 2019Assignees: LEICA MICROSYSTEMS CMS GMBH, EMBL EUROPEAN MOLECULAR BIOLOGY LABORATORYInventors: Frank Sieckmann, Urban Liebel
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Patent number: 9588329Abstract: A method for scanning a sample using an electrically or electronically controllable microscope, includes scanning the sample so as to generate a plurality of images of the sample, each of the plurality of images corresponding to at least one of a different region of the sample and a different time. The microscope is controlled via a control computer during the scanning. The plurality of images are analyzed using at least one second computer connected via a network. The plurality of images are classified and/or the scanning is influenced based on the analyzing.Type: GrantFiled: September 6, 2007Date of Patent: March 7, 2017Assignees: LEICA MICROSYSTEMS CMS GMBH, EMBL EUROPEAN MOLECULAR BIOLOGY LABORATORYInventors: Frank Sieckmann, Urban Liebel
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Publication number: 20150218539Abstract: The present invention relates to an activator of the calcineurin subunit A?1 isofomi (CnA?1) or of the C-terminal domain of the calcineurin subunit A?1 isofomi (CnA?1) for the production of a medicament for the modulation of myocardial growth without adversely affecting contractile function.Type: ApplicationFiled: August 16, 2013Publication date: August 6, 2015Applicant: EMBL EUROPEAN MOLECULAR BIOLOGY LABORATORYInventors: Enrique Lara Pezzi, Marina López Olaneta, Maria Villalba Orero, Jesús Gómez Salinero, Nadia Rosenthal
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Patent number: 8931357Abstract: A two-part coaxial needle for a pipetting device, in particular for use in microscopy of cell probes, makes it possible both to inject a liquid into a pipetting container and to remove by suction a liquid from the pipetting container. Both the drive for lowering the coaxial needle into the pipetting container, and injection and removal by suction of the liquid take place pneumatically by way of only one pressure source. The design of the coaxial needle and of the drive systems makes possible fast and reliable pipetting with high metering accuracy and a particularly compact pipetting unit which without mutual interference can be used with a multitude of widely-used microscope types.Type: GrantFiled: December 3, 2009Date of Patent: January 13, 2015Assignee: EMBL European Molecular Biology LaboratoryInventors: Siegfried Winkler, Christian Conrad
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Patent number: 8199407Abstract: An immersion objective for microscopic investigation of a specimen is provided wherein an outer lens is disposed in an objective body. A delivery device including a cap that is disposed over the objective body so as to form a space adapted to receive an immersion liquid is also provided. The cap is open in a region of the outer lens so as to form a gap with the outer lens. The cap includes at least one connector configured to provide a continuous supply of the immersion liquid to the space so that the immersion liquid emerges through the gap to a region between the outer lens and at least one of the specimen and a specimen slide.Type: GrantFiled: September 7, 2007Date of Patent: June 12, 2012Assignees: Leica Microsystems CMS GmbH, EMBL European Molecular Biology LaboratoryInventors: Urban Liebel, Siegfried Winkler, Frank Sieckmann
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Publication number: 20110277565Abstract: A two-part coaxial needle for a pipetting device, in particular for use in microscopy of cell probes, makes it possible both to inject a liquid into a pipetting container and to remove by suction a liquid from the pipetting container. Both the drive for lowering the coaxial needle into the pipetting container, and injection and removal by suction of the liquid take place pneumatically by way of only one pressure source. The design of the coaxial needle and of the drive systems makes possible fast and reliable pipetting with high metering accuracy and a particularly compact pipetting unit which without mutual interference can be used with a multitude of widely-used microscope types.Type: ApplicationFiled: December 3, 2009Publication date: November 17, 2011Applicant: EMBL EUROPEAN MOLECULAR BIOLOGY LABORATORYInventors: Siegfried Winkler, Christian Conrad
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Publication number: 20100103253Abstract: A method for scanning a sample using an electrically or electronically controllable microscope, includes scanning the sample so as to generate a plurality of images of the sample, each of the plurality of images corresponding to at least one of a different region of the sample and a different time. The microscope is controlled via a control computer during the scanning. The plurality of images are analyzed using at least one second computer connected via a network. The plurality of images are classified and/or the scanning is influenced based on the analyzing.Type: ApplicationFiled: September 6, 2007Publication date: April 29, 2010Applicants: LEICA MICROSYSTEMS CMS GMBH, EMBL EUROPEAN MOLECULAR BIOLOGY LABORATORYInventors: Frank Sieckmann, Urban Liebel
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Publication number: 20100027109Abstract: An immersion objective for microscopic investigation of a specimen is provided wherein an outer lens is disposed in an objective body. A delivery device including a cap that is disposed over the objective body so as to form a space adapted to receive an immersion liquid is also provided. The cap is open in a region of the outer lens so as to form a gap with the outer lens. The cap includes at least one connector configured to provide a continuous supply of the immersion liquid to the space so that the immersion liquid emerges through the gap to a region between the outer lens and at least one of the specimen and a specimen slide.Type: ApplicationFiled: September 7, 2007Publication date: February 4, 2010Applicants: Leica Microsystems CMS GmbH, EMBL European Molecular Biology LaboratoryInventors: Urban Liebel, Siegfried Winkler, Frank Sieckmann