Patents Assigned to EmendoBio Inc.
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Publication number: 20240132881Abstract: RNA molecules comprising a guide sequence portion having 17-20 nucleotides in the sequence of 17-20 contiguous nucleotides set forth in any one of SEQ ID NOs: 1-3010 and compositions, methods, and uses thereof.Type: ApplicationFiled: October 24, 2023Publication date: April 25, 2024Applicant: EmendoBio, Inc.Inventors: Lior Izhar, David Baram, Joseph Georgeson, Michal Golan-Mashiach, Asael Herman, Rafi Emmanuel
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Publication number: 20240131121Abstract: The present invention provides a non-naturally occurring composition comprising a CRISPR nuclease comprising a sequence having at least 95% identity to the amino acid sequence of SEQ ID NO: 3 or a nucleic acid molecule comprising a sequence encoding the CRISPR nuclease.Type: ApplicationFiled: April 5, 2023Publication date: April 25, 2024Applicant: EmendoBio Inc.Inventors: David Baram, Lior Izhar, Asael Herman, Liat Rockah, Nadav Marbach-Bar, Nurit Meron, Joseph Georgeson
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Publication number: 20240132884Abstract: The present invention relates to compositions and methods for increasing the rate of site specific insertion of a donor DNA sequence to the genome. More specifically, the method introduces a donor DNA template containing at least one transcription factor binding site to a cell in order to favor specific insertion of a donor template sequence at a target site by homology directed repair (HDR).Type: ApplicationFiled: September 27, 2023Publication date: April 25, 2024Applicant: EmendoBio Inc.Inventors: David Baram, Lior Izhar, Rafi Emmanuel
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Publication number: 20240042025Abstract: RNA molecules comprising a guide sequence portion having 17-50 contiguous nucleotides containing nucleotides in the sequence set forth in any one of SEQ ID NOs: 1-1538 and compositions, methods, and uses thereof.Type: ApplicationFiled: December 14, 2021Publication date: February 8, 2024Applicant: EmendoBio Inc.Inventors: Lior Izhar, Rafi Emmanuel
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Publication number: 20240002840Abstract: A composition comprising a non-naturally occurring RNA molecule, the RNA molecule comprising an RNA scaffold portion, the RNA scaffold portion having the structure: crRNA repeat sequence portion-Linker portion-tracrRNA portion; wherein the RNA scaffold portion forms a complex with and targets an OMNI-50 CRISPR nuclease to a DNA target site having complementarity to a guide sequence portion of the RNA molecule.Type: ApplicationFiled: November 3, 2021Publication date: January 4, 2024Applicants: EmendoBio Inc.Inventors: Lior Izhar, Liat Rockah, Nadav Marbach Bar
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Publication number: 20240000970Abstract: RNA molecules comprising a guide sequence portion having 17-50 contiguous nucleotides in the sequence set forth in any one of SEQ ID NOs: 1-103,606 and compositions, methods, and uses thereof.Type: ApplicationFiled: December 1, 2021Publication date: January 4, 2024Applicant: EmendoBio Inc.Inventors: Rafi Emmanuel, Michal Golan Mashiach
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Publication number: 20230383273Abstract: The present invention provides a non-naturally occurring composition comprising a CRISPR nuclease comprising a sequence having at least 90% identity to the amino acid sequence selected from the group consisting of SEQ ID NOs: 1-8 or a nucleic acid molecule comprising a sequence encoding the CRISPR nuclease.Type: ApplicationFiled: October 20, 2021Publication date: November 30, 2023Applicant: EmendoBio Inc.Inventors: Lior Izhar, Liat Rockah, Nadav Marbach Bar, Nurit Meron
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Patent number: 11827879Abstract: RNA molecules comprising a guide sequence portion having 17-20 nucleotides in the sequence of 17-20 contiguous nucleotides set forth in any one of SEQ ID NOs: 1-3010 and compositions, methods, and uses thereof.Type: GrantFiled: November 28, 2018Date of Patent: November 28, 2023Assignee: EmendoBio, Inc.Inventors: Lior Izhar, David Baram, Joseph Georgeson, Michal Golan-Mashiach, Asael Herman, Rafi Emmanuel
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Patent number: 11795453Abstract: The present invention relates to compositions and methods for increasing the rate of site specific insertion of a donor DNA sequence to the genome. More specifically, the method introduces a donor DNA template containing at least one transcription factor binding site to a cell in order to favor specific insertion of a donor template sequence at a target site by homology directed repair (HDR).Type: GrantFiled: October 30, 2017Date of Patent: October 24, 2023Assignee: EMENDOBIO, INC.Inventors: David Baram, Lior Izhar, Rafi Emmanuel
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Publication number: 20230332146Abstract: RNA molecules comprising a guide sequence portion having 17-50 contiguous nucleotides containing nucleotides in the sequence set forth in any one of SEQ ID NOs: 1-20640 and compositions, methods, and uses thereof.Type: ApplicationFiled: May 28, 2021Publication date: October 19, 2023Applicant: EmendoBio Inc.Inventors: Rafi Emmanuel, Joseph Dicken, Michal Golan Mashiach
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Publication number: 20230303989Abstract: The present invention provides a non-naturally occurring composition comprising a CRISPR nuclease comprising a sequence having at least 95% identity to the amino acid sequence of SEQ ID NO: 1 or a nucleic acid molecule comprising a sequence encoding the CRISPR nuclease.Type: ApplicationFiled: February 7, 2022Publication date: September 28, 2023Applicant: EmendoBio Inc.Inventors: Lior Izhar, Nadav Marbach Bar, Liat Rockah, Nurit Meron, Ophir Adiv Tal, Ariel Gispan, Idit Buch, Nir Hecht
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Publication number: 20230287428Abstract: RNA molecules comprising a guide sequence portion having 17-50 contiguous nucleotides containing nucleotides in the sequence set forth in any one of SEQ ID NOs: 1-12105 and compositions, methods, and uses thereof.Type: ApplicationFiled: May 27, 2021Publication date: September 14, 2023Applicant: EmendoBio Inc.Inventors: Rafi Emmanuel, Michal Golan Mashiach
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Publication number: 20230212562Abstract: RNA molecules comprising a guide sequence portion having 17-50 contiguous nucleotides containing nucleotides in the sequence set forth in any one of SEQ ID NOs: 1-20246 and compositions, methods, and uses thereof.Type: ApplicationFiled: May 28, 2021Publication date: July 6, 2023Applicant: EmendoBio Inc.Inventors: Rafi Emmanuel, Joseph Dicken, Michal Golan Mashiach
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Publication number: 20230175020Abstract: RNA molecules comprising a guide sequence portion having 17-25 contiguous nucleotides containing nucleotides in the sequence set forth in any one of SEQ ID NOs: 1-6601 and compositions, methods, and uses thereof.Type: ApplicationFiled: March 27, 2020Publication date: June 8, 2023Applicant: EmendoBio Inc.Inventors: David Baram, Lior Izhar, Asael Herman, Rafi Emmanuel, Michal Golan Mashiach, Joseph Georgeson
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Publication number: 20230173107Abstract: RNA molecules comprising a guide sequence portion having 17-20 nucleotides in the sequence of 17-20 contiguous nucleotides set forth in any one of SEQ ID NOs: 1-3010 and compositions, methods, and uses thereof.Type: ApplicationFiled: November 28, 2018Publication date: June 8, 2023Applicant: EmendoBio Inc.Inventors: Lior Izhar, David Baram, Joe Georgeson, Michal Golan-Mashiach, Asael Herman, Rafi Emmanuel
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Publication number: 20230173106Abstract: RNA molecules comprising a guide sequence portion having 17-20 nucleotides in the sequence of 17-20 contiguous nucleotides set forth in any one of SEQ ID NOs: 1-3010 and compositions, methods, and uses thereof.Type: ApplicationFiled: November 28, 2018Publication date: June 8, 2023Applicant: EmendoBio Inc.Inventors: Lior Izhar, David Baram, Joe Georgeson, Michal Golan-Mashiach, Asael Herman, Rafi Emmanuel
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Publication number: 20230174974Abstract: RNA molecules comprising a guide sequence portion having 17-20 nucleotides in the sequence of 17-20 contiguous nucleotides set forth in any one of SEQ ID NOs: 1-3010 and compositions, methods, and uses thereof.Type: ApplicationFiled: November 28, 2018Publication date: June 8, 2023Applicant: EmendoBio Inc.Inventors: Lior Izhar, David Baram, Joe Georgeson, Michal Golan-Mashiach, Asael Herman, Rafi Emmanuel
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Publication number: 20230173105Abstract: RNA molecules comprising a guide sequence portion having 17-20 nucleotides in the sequence of 17-20 contiguous nucleotides set forth in any one of SEQ ID NOs: 1-3010 and compositions, methods, and uses thereofType: ApplicationFiled: November 28, 2018Publication date: June 8, 2023Applicant: EmendoBio Inc.Inventors: Lior Izhar, David Baram, Joe Georgeson, Michal Golan-Mashiach, Asael Herman, Rafi Emmanuel
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Patent number: 11666641Abstract: The present invention provides a non-naturally occurring composition comprising a CRISPR nuclease comprising a sequence having at least 95% identity to the amino acid sequence of SEQ ID NO: 3 or a nucleic acid molecule comprising a sequence encoding the CRISPR nuclease.Type: GrantFiled: April 30, 2020Date of Patent: June 6, 2023Assignee: EMENDOBIO INC.Inventors: David Baram, Lior Izhar, Asael Herman, Liat Rockah, Nadav Marbach-Bar, Nurit Meron, Joseph Georgeson
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Publication number: 20230122086Abstract: The present invention provides a non-naturally occurring composition comprising a CRISPR nuclease comprising a sequence having at least 95% identity to the amino acid sequence selected from the group consisting of SEQ ID NOs: 1-8 or a nucleic acid molecule comprising a sequence encoding the CRISPR nuclease.Type: ApplicationFiled: June 4, 2021Publication date: April 20, 2023Applicant: EmendoBio Inc.Inventors: Lior Izhar, Liat Rockah, Nadav Marbach Bar, Nurit Meron
