Patents Assigned to Emerald BioStructures, Inc.
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Publication number: 20140073055Abstract: A nanovolume microcapillary crystallization system allows nanoliter-volume screening of crystallization conditions in a crystal card that allows crystals to either be removed for traditional cryoprotection or in situ X-ray diffraction studies on protein crystals that grow within. The system integrates formulation of crystallization cocktails with preparation of the crystallization experiments. The system allows the researcher to select either gradient screening in crystallization experiments for efficient exploration of crystallization phase space or a combination of sparse matrix with gradient screening to execute one comprehensive hybrid crystallization trial.Type: ApplicationFiled: February 25, 2013Publication date: March 13, 2014Applicant: EMERALD BIOSTRUCTURES, INC.Inventor: EMERALD BIOSTRUCTURES, INC.
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Patent number: 7203683Abstract: This invention encompasses an apparatus for creating a database containing the results of distributed molecular replacement searches, which comprise data input system for inputting the results of distributed molecular replacement searches and related information and a database generator coupled to said data input system for receiving the results of distributed molecular replacement searches and related information and creating a database for storing the results of distributed molecular replacement searches and related information. The invention includes method of managing the invention of distributed molecular replacement searches.Type: GrantFiled: October 11, 2002Date of Patent: April 10, 2007Assignee: Emerald BioStructures, Inc.Inventors: Mark B. Mixon, Michael Feese, Lance Stewart, Sridhar Prasad
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Patent number: 6950757Abstract: This invention relates to crystallization based assays for identifying ligands that bind to a macromolecule.Type: GrantFiled: April 11, 2002Date of Patent: September 27, 2005Assignee: Emerald BioStructures, Inc.Inventor: Lansing J. Stewart
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Publication number: 20050003502Abstract: This invention relates to crystalline structures of the topoisomerase I and their use in designing new anti-cancer agents anti-viral agents and anti-microbial agents.Type: ApplicationFiled: November 14, 2001Publication date: January 6, 2005Applicant: Emerald BioStructures, Inc.Inventors: Alex Burgin, Kathyrn Hjerrild, Hidong Kim, Bart Staker, Lance Stewart, Craig Behnke, Michael Feese
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Patent number: 6818060Abstract: A matrix mixing robot includes a plurality of precision pumps (such as precision syringe pumps), a distributor and a processor system. Each pump, under the control of the processor system, draws an associated stock solution from a stock solution source, and pumps the drawn stock solution out through an outlet. The distributor, also under the control of the processor system, directs a stock solution from a particular pump outlet to a selected solution receptacle. A multi-port distribution valve may be associated with each precision pump. Each valve, under control of the processor system, can connect its associated pump to one the pump's inlets or outlets.Type: GrantFiled: June 26, 2002Date of Patent: November 16, 2004Assignee: Emerald BioStructures, Inc.Inventors: Lansing J. Stewart, Alexandrina Muntianu, Robin Clark
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Patent number: 6811608Abstract: Disclosed is a system and a method for depositing crystallization observations into a relational database. The system includes a computer, microscope, and a headset having a microphone and headphones. Crystallization observations are deposited into the database by verbal commands. Verbal commands also drive the crystallization apparatus plates to position the apparatus wells within the microscope field of vision. The system is integrated with a software application which enables the user to build the trials, matrices, solutions, and macromolecules to be used in the crystallization trials. The user is guided through the crystallization trial setup by a multitude of managers and builders of the software application. The software application also provides numerous tools to query the database and display results in a multitude of formats.Type: GrantFiled: August 2, 2000Date of Patent: November 2, 2004Assignee: Emerald Biostructures, Inc.Inventors: Lansing J. Stewart, Hidong Kim, Lucius B. C. A. Fleuchaus, Paul M. Dunn
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Publication number: 20040215398Abstract: This invention encompasses an apparatus for creating a database containing the results of distributed molecular replacement searches, which comprise data input system for inputting the results of distributed molecular replacement searches and related information and a database generator coupled to said data input system for receiving the results of distributed molecular replacement searches and related information and creating a database for storing the results of distributed molecular replacement searches and related information. The invention includes method of managing the invention of distributed molecular replacement searches.Type: ApplicationFiled: October 11, 2002Publication date: October 28, 2004Applicant: Emerald Biostructures, Inc.Inventors: Mark B. Mixon, Michael Feese, Lance J. Stewart, Sridhar Prasad
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Patent number: 6599441Abstract: In one aspect, the present invention provides sets of crystallization solutions that each comprise a crystallization solution set selected from the group of crystallization solution sets consisting of Crystallization Solution Set 1, Crystallization Solution Set 2, Crystallization Solution Set 3, Crystallization Solution Set 4 and Crystallization Solution Set 5. In another aspect, the present invention provides kits that each comprise at least one crystallization plate and a Crystallization Solution Set of the invention.Type: GrantFiled: July 3, 2001Date of Patent: July 29, 2003Assignee: Emerald BioStructures, Inc.Inventors: Mary Ann Chrislip, Bart Staker
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Publication number: 20030072683Abstract: A matrix mixing robot includes a plurality of precision pumps (such as precision syringe pumps), a distributor and a processor system. Each pump, under the control of the processor system, draws an associated stock solution from a stock solution source, and pumps the drawn stock solution out through an outlet. The distributor, also under the control of the processor system, directs a stock solution from a particular pump outlet to a selected solution receptacle. A multi-port distribution valve may be associated with each precision pump. Each valve, under control of the processor system, can connect its associated pump to one the pump's inlets or outlets.Type: ApplicationFiled: June 26, 2002Publication date: April 17, 2003Applicant: Emerald BioStructures, Inc.Inventors: Lansing J. Stewart, Alexandrina Muntianu, Robin Clark
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Patent number: 6039804Abstract: The present invention provides a crystallization unit including a solvent reservoir in gaseous communication with a plurality of chambers. Preferably, a plurality of crystallization units are arrayed in the form of a crystallization tray. A first preferred embodiment of the present invention provides a crystallization tray 10 including a rectangular array of crystallization units 26. Each crystallization unit includes a central reservoir 28 and four drop chambers 32 arranged in a cruciform configuration around central reservoir 28. Each drop chamber 32 is connected to central reservoir 28 by a diffusion channel 30. Each drop chamber 32 also includes a shoulder which is capable of supporting a cover slip from which a drop of solution, containing the substance to be crystallized, can be suspended.Type: GrantFiled: September 9, 1998Date of Patent: March 21, 2000Assignee: Emerald BioStructures, Inc.Inventors: Hidong Kim, Lansing Joseph Stewart