Patents Assigned to Emisphere Technologies, Inc.
  • Compositions for delivering peptide YY and PYY agonists
    Publication number: 20050009748
    Abstract: The present invention provides a composition (e.g., a pharmaceutical composition) comprising at least one delivery agent compound and at least one of peptide YY (PYY) and a PYY agonist. Preferably, the composition includes a therapeutically effective amount of peptide YY or the PYY agonist and the delivery agent compound. The composition of the present invention facilitates the delivery of PYY, a PYY agonist, or a mixture thereof and increases its bioavailability compared to administration without the delivery agent compound.
    Type: Application
    Filed: May 14, 2004
    Publication date: January 13, 2005
    Applicant: Emisphere Technologies, Inc.
    Inventors: Steve Dinh, Huaizhen Wang, M. Gomez-Orellana
  • Compounds and compositions for delivering active agents
    Publication number: 20040110839
    Abstract: Modified, amino acid compounds useful in the delivery of active agents are provided. The active agents can be peptides, such as rhGH. Methods of administration, such as oral, subcutaneous, sublingual, and intranasal administration, are provided, and methods of preparation of the modified amino acid compound are provided.
    Type: Application
    Filed: July 18, 2003
    Publication date: June 10, 2004
    Applicant: Emisphere Technologies, Inc.
    Inventors: Andrea Leone-Bay, Koc-Kan Ho, Donald J. Sarubbi, Sam J. Milstein
  • Disodium salts, monohydrates, and ethanol solvates for delivering active agents
    Publication number: 20040106825
    Abstract: The inventors have discovered that the disodium salt of certain delivery agents has surprisingly greater efficacy for delivering active agents than the corresponding monosodium salt. Furthermore, the inventors have discovered that the disodium salts of these delivery agents form solvates with ethanol and hydrates with water.
    Type: Application
    Filed: July 7, 2003
    Publication date: June 3, 2004
    Applicant: Emisphere Technologies, Inc.
    Inventors: William E. Bay, Rajesh K. Agarwal, Kiran Chaudhary, Shingai Majuru, Michael M. Goldberg, JoAnne P. Russo
  • Compounds and compositions for delivering active agents
    Publication number: 20040068013
    Abstract: Modified amino acid compounds useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Application
    Filed: October 1, 2003
    Publication date: April 8, 2004
    Applicant: Emisphere Technologies, Inc.
    Inventors: Andrea Leone-Bay, Duncan R. Paton, Koc-Kan Ho, Frenel DeMorin
  • Compositions for the delivery of antigens
    Publication number: 20040062773
    Abstract: The present invention relates to compositions and methods for orally delivering antigens. The antigen and an adjuvant are combined with an acylated amino acid or polyamino acid and, a sulfonated amino acids or polyamino acid, or a salt of the foregoing.
    Type: Application
    Filed: June 19, 2003
    Publication date: April 1, 2004
    Applicant: Emisphere Technologies Inc.
    Inventors: Noemi B. Santiago, Susan Haas, Andrea Leone-Bay, Sam J. Milstein, Evgueni Barantsevitch
  • Compounds and compositions for delivering active agents
    Patent number: 6699467
    Abstract: Modified amino acid compounds useful in the delivery of active agents are provided. The active agents can be peptides. Methods of administration, such as oral, subcutaneous, sublingual, and intranasal administration and methods of preparation of the modified amino acid compounds are also provided.
    Type: Grant
    Filed: May 8, 2002
    Date of Patent: March 2, 2004
    Assignee: Emisphere Technologies, Inc.
    Inventors: Andrea Leone-Bay, Koc-Kan Ho, Donald J. Sarubbi, Sam J. Milstein
  • Compounds and compositions for delivering active agents
    Patent number: 6693208
    Abstract: Amino acid derivative as carrier compounds and compositions which are useful in the delivery of active agents are provided. The active agents can be a peptide, mucopolysaccharide, carbohydrate, or lipid. Methods of administration, including oral administration, and preparation are provided as well.
    Type: Grant
    Filed: July 15, 2002
    Date of Patent: February 17, 2004
    Assignee: Emisphere Technologies, Inc.
    Inventors: David Gscheidner, Andrea Leone-Bay, Eric Wang, John J. Freeman, Doris C. O'Toole, Lynn Shields
  • Pulmonary delivery of active agents
    Patent number: 6693073
    Abstract: The present invention provides methods for administering an active agent to an animal in need of the agent by the pulmonary route. This method comprises administering via the pulmonary route, a composition comprising (a) an active agent and (b)(i) an acylated amino acid, (ii) a sulfonated amino acid, or (iii) a combination of (i) and (ii). Administration of the compositions of the present invention provide improved pulmonary delivery and greater bioavailability of the active agent than administration of the active agent alone. As a result, lesser amounts of the active agent may be administered to obtain a desired result when contained in the composition of the present invention than when administered alone.
    Type: Grant
    Filed: June 14, 2002
    Date of Patent: February 17, 2004
    Assignee: Emisphere Technologies, Inc.
    Inventors: Sam J. Milstein, John E. Smart, Donald J. Sarubbi, Monica Leipold, Elizabeth Flanders, Doris O'Toole, Andrea Leone-Bay, David Gschneidner
  • Compounds and compositions for delivering active agents
    Publication number: 20040022856
    Abstract: Carrier compounds and compositions therewith which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Application
    Filed: March 24, 2003
    Publication date: February 5, 2004
    Applicant: Emisphere Technologies, Inc.
    Inventors: Donald J. Sarubbi, Eugene N. Barantsevich
  • Compounds and compositions for delivering active agents
    Publication number: 20030235612
    Abstract: Carrier compounds and compositions therewith which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Application
    Filed: February 24, 2003
    Publication date: December 25, 2003
    Applicant: Emisphere Technologies, Inc.
    Inventors: Andrea Leone-Bay, Eric Wang, Donald J. Sarubbi, Harry Leipold, David Gschneidner, Koc-Kan Ho
  • Polymeric delivery agents and delivery agent compounds
    Publication number: 20030232085
    Abstract: Polymeric delivery agents, delivery agent compounds and compositions comprising them which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Application
    Filed: May 28, 2003
    Publication date: December 18, 2003
    Applicants: Emisphere Technologies, Inc., Virginia Commonwealth University
    Inventors: Sam J. Milstein, Eugene N. Barantsevitch, Nai Fang Wang, Jun Liao, John E. Smart, Richard D. Conticello, Raphael M. Ottenbrite
  • Carbon-substituted diketopiperazine delivery systems
    Patent number: 6663898
    Abstract: Compositions useful in the delivery of active agents are provided. These delivery compositions include (a) an active agent; and (b) a carrier of at least one mono-C-substituted or di-C-substituted diketopiperazine. Methods for preparing these compositions and administering these compositions are also provided.
    Type: Grant
    Filed: April 19, 2002
    Date of Patent: December 16, 2003
    Assignee: Emisphere Technologies, Inc.
    Inventor: Sam J. Milstein
  • Compounds and compositions for delivering active agents
    Patent number: 6663887
    Abstract: Modified amino acid compounds useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Grant
    Filed: February 21, 2002
    Date of Patent: December 16, 2003
    Assignee: Emisphere Technologies, Inc.
    Inventors: Andrea Leone-Bay, Duncan R. Paton, Koc-Kan Ho, Frenel DeMorin
  • Compounds and compositions for delivering active agents
    Publication number: 20030225300
    Abstract: Carrier compounds and compositions therewith which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Application
    Filed: June 20, 2003
    Publication date: December 4, 2003
    Applicant: Emisphere Technologies Inc.
    Inventors: Andrea Leone-Bay, Doris O'Toole
  • Compounds and compositions for delivering active agents
    Patent number: 6646162
    Abstract: Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Grant
    Filed: August 24, 2001
    Date of Patent: November 11, 2003
    Assignee: Emisphere Technologies, Inc.
    Inventors: Pingwah Tang, Andrea Leone-Bay, David Gschneidner
  • Compounds and compositions for delivering active agents
    Patent number: 6642411
    Abstract: Carrier compounds and compositions therewith which are useful in the delivery of active agents are provided Methods of administration and preparation are provided as well.
    Type: Grant
    Filed: April 19, 2001
    Date of Patent: November 4, 2003
    Assignee: Emisphere Technologies, Inc.
    Inventors: Andrea Leone-Bay, Doris O'Toole
  • Carbon-substituted diketopiperazine delivery systems
    Publication number: 20030198658
    Abstract: Compositions useful in the delivery of active agents are provided. These delivery compositions include (a) an active agent; and (b) a carrier of at least one mono-C-substituted or di-C-Substituted diketopiperazine. Methods for preparing these compositions and administering these compositions are also provided.
    Type: Application
    Filed: May 21, 2003
    Publication date: October 23, 2003
    Applicant: Emisphere Technologies, Inc.
    Inventor: Samuel J. Milstein
  • Polymeric delivery agents and delivery agents compounds
    Patent number: 6627228
    Abstract: Polymeric delivery agents, delivery agent compounds and compositions comprising them which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Grant
    Filed: October 9, 2001
    Date of Patent: September 30, 2003
    Assignee: Emisphere Technologies, Inc.
    Inventors: Sam J. Milstein, Eugene N. Barantsevitch, Nai Fang Wang, Jun Liao, John E. Smart, Richard D. Conticello, Raphael M. Ottenbrite
  • Compounds and compositions for delivering active agents
    Patent number: 6623731
    Abstract: Modified amino acid compounds useful in the delivery of active agents are provided. The active agents can be peptides, such as rhGH. Methods of administration, such as oral, subcutaneous, sublingual, and intranasal administration, are provided, and methods of preparation of the modified amino acid compound are provided.
    Type: Grant
    Filed: October 19, 2001
    Date of Patent: September 23, 2003
    Assignee: Emisphere Technologies, Inc.
    Inventors: Andrea Leone-Bay, Koc-Kan Ho, Donald J. Sarubbi, Sam J. Milstein
  • Compositions for the delivery of antigens
    Patent number: 6610329
    Abstract: The present invention relates to compositions and methods for orally delivering antigens. The antigen and an adjuvant are combined with an acylated amino acid or polyamino acid and, a sulfonated amino acids or polyamino acid, or a salt of the foregoing.
    Type: Grant
    Filed: May 21, 2001
    Date of Patent: August 26, 2003
    Assignee: Emisphere Technologies Inc.
    Inventors: Noemi B. Santiago, Susan Haas, Andrea Leone-Bay, Sam J. Milstein, Evgueni Barantsevitch