Abstract: A fluorescence histo-tomography (FHT) method may include capturing, using an imaging device positioned with respect to a chamber of a slicing apparatus, images of a block face of a specimen retained within the chamber. The images may be captured in the visible and infrared or near-infrared spectrum. The method may include co-registering the images to form a combined image, and providing the combined image to an electronic display. In some implementations, the method may include positioning the imaging device away from the chamber, operating the slicing apparatus to expose a second block face of the specimen, and repositioning the imaging device with respect to the chamber.

Abstract: In one embodiment, a fluorescence histo-tomography (FHT) system is disclosed. The FHT system includes an imaging housing, a fluorescence camera located within the housing, a white light camera located within the imaging housing, and a fluorescence light source located within the imaging housing. The FHT system further includes a support mount configured to support the imaging housing within a chamber of a slicing apparatus such that the cameras and fluorescence light source are aimed towards a block face of a tissue specimen retained within the chamber.

Abstract: In one embodiment, a fluorescence histo-tomography (FHT) system is disclosed. The FHT system includes a housing, a fluorescence camera located within the housing, a white light camera located within the housing, and a fluorescence light source located within the housing. The FHT system further includes a support mount configured to support the housing within a chamber of a slicing apparatus such that the cameras and fluorescence light source are aimed towards a block face of a tissue specimen retained within the chamber.