Abstract: The invention relates to proteins that contain the CD4 domain 1 and the CD4 domain 2 (CD4 D1D2), wherein the CD4 D1D2 contains one or more mutations compared to wild-type human CD4 D1D2, and to methods of using the proteins for treating a human immunodeficiency virus (HIV) infection in a subject.
Type:
Grant
Filed:
March 21, 2019
Date of Patent:
March 18, 2025
Assignees:
UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED, EMMUNE, INC.
Inventors:
Michael Farzan, Matthew Gardner, Ina Fetzer, Michael Alpert, Charles Bailey