Abstract: The invention is directed to a composition comprising: a polyurethane substrate; a hydrogel forming polymer on at least one of the two faces of the polyurethane substrate; and chlorhexidine on the at least one face comprising the hydrogel forming polymer; wherein the hydrogel polymer is covalently linked to the polyurethane substrate.

Abstract: The invention relates to an antimicrobial dressing, an anti-microbial composition and use thereof. The dressing comprises: chlorhexidine and/or a pharmaceutically acceptable salt thereof in a solid state in a quantity, calculated as an equivalent weight of chlorhexidine digluconate/surface of dressing, comprised between 0.013 and 2 g/m2; and silver and/or a pharmaceutically-acceptable salt in the solid state in a quantity, calculated as an equivalent weight of metallic silver/surface of dressing of greater than or equal to 0.1 g/m2. The composition comprises: chlorhexidine and/or a pharmaceutically acceptable salt thereof in a solid state in a relative weight/weight percentage, calculated as an equivalent weight of chlorhexidine digluconate/total weight of the composition, comprised between 0.01% and 0.09%; and silver and/or a pharmaceutically acceptable salt thereof in the solid state in a relative percentage weight/weight comprised between 0.00008% and 0.