Patents Assigned to Emory University
  • Publication number: 20210244307
    Abstract: A process for more sensitive characterization of tissue composition for generating a quantitative MRI (qMRI) map and corresponding delta analysis. Intervertebral disc degeneration (IVDD), resulting in the depletion of hydrophilic glycosaminoglycans (GAGs) located in the nucleus pulposus (NP), can lead to debilitating neck and back pain. Magnetic Resonance Imaging (MRI) is a promising means of IVD assessment due to the correlation between GAG content and MRI relaxation values. T1 and T2 relaxation data were obtained from healthy cervical IVDs, and relaxation data was modeled using both conventional and stretched exponential (SE) decays. Normalized histograms of the resultant quantitative MRI (qMRI) maps were fit with stable distributions. SE models fit relaxation behavior with lower error compared to monoexponential models, indicating anomalous relaxation behavior in healthy IVDs. SE model parameters T1 and T1 increased with IVD segment, while conventional monoexponential measures did not vary.
    Type: Application
    Filed: July 8, 2019
    Publication date: August 12, 2021
    Applicants: The Regents of the University of Colorado, a body corporate, Emory University
    Inventors: Corey P. Neu, Robert L. Wilson, David Reiter
  • Patent number: 11077120
    Abstract: The disclosure relates to Prostaglandin receptor EP2 antagonists, derivatives, compositions, and methods related thereto. In certain embodiments, the disclosure relates to methods of treating or preventing conditions and diseases in which EP2 receptor activation has a physiological role, such as but not limited to, brain injury, inflammatory diseases, neuroinflammation after a seizure, pain, endometriosis, cancer, rheumatoid arthritis, skin inflammation, vascular inflammation, colitis, and neurological disorders by administering a pharmaceutical composition comprising a compound disclosed herein to a subject in need thereof.
    Type: Grant
    Filed: November 15, 2019
    Date of Patent: August 3, 2021
    Assignee: Emory University
    Inventors: Thota Ganesh, Jianxiong Jiang, Raymond Dingledine
  • Patent number: 11079395
    Abstract: Provided herein are methods for predicting or determining whether a subject with coronary artery disease is likely to experience or develop a major adverse cardiovascular event (MACE) based on determining cardiac troponin (cTnI) levels in a human at rest and during or after exercise.
    Type: Grant
    Filed: February 28, 2020
    Date of Patent: August 3, 2021
    Assignees: Abbott Laboratories, Emory University
    Inventors: Agim Beshiri, Arshed A. Quyyumi
  • Patent number: 11065261
    Abstract: This disclosure relates to extracts from the Anacardiaceae (cashew plant family) and compositions comprising compounds contained therein. In certain embodiments, the extracts are derived from the fruit of a Schinus plant. In certain embodiments, the disclosure relates to methods of treating or preventing bacterial infections, acne, and other related uses.
    Type: Grant
    Filed: March 1, 2019
    Date of Patent: July 20, 2021
    Assignee: Emory University
    Inventors: Cassandra L. Quave, James Lyles, Gina Porras-Brenes, Huaqiao Tang
  • Patent number: 11065254
    Abstract: Compounds, compositions, and methods of treatment and prevention of HIV infection are disclosed. The compounds are pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidine JAK inhibitors. Combinations of these JAK inhibitors and additional antiretroviral compounds, such as NRTI, NNRTI, integrase inhibitors, entry inhibitors, protease inhibitors, and the like, are also disclosed. In one embodiment, the combinations include a combination of adenine, cytosine, thymidine, and guanine nucleoside antiviral agents, optionally in further combination with at least one additional antiviral agent that works via a different mechanism than a nucleoside analog. This combination has the potential to eliminate the presence of HIV in an infected patient.
    Type: Grant
    Filed: March 11, 2020
    Date of Patent: July 20, 2021
    Assignees: The United States Government As Represented By The Department of Veterans Affairs, Emory University
    Inventors: Christina Gavegnano, Raymond F. Schinazi
  • Patent number: 11052090
    Abstract: Compounds, compositions, and methods of treatment and prevention of HIV, including HIV-1 and HIV-2, Dengue, and Chikungunya infection are disclosed. The compounds are TREM-1 inhibitors. Combinations of these TREM-1 inhibitors and additional antiretroviral compounds, such as NRTI, NNRTI, integrase inhibitors, entry inhibitors, protease inhibitors, JAK inhibitors, macrophage depleting agents, and the like, are also disclosed. In one embodiment, the combinations include a combination of adenine, cytosine, thymidine, and guanine nucleoside antiviral agents, optionally in further combination with at least one additional antiviral agent that works via a different mechanism than a nucleoside analog. This combination has the potential to eliminate the presence of HIV, Dengue, or Chikungunya virus in an infected patient.
    Type: Grant
    Filed: February 12, 2020
    Date of Patent: July 6, 2021
    Assignees: Emory University, Children's Healthcare of Atlanta, Inc.
    Inventors: Raymond F. Schinazi, Christina Gavegnano
  • Patent number: 11053292
    Abstract: In certain embodiments, this disclosure relates to conjugates comprising a polypeptide of GM-CSF and a polypeptide IL-4. Typically, the GM-CSF and IL-4 are connected by a linker, e.g., polypeptide. In certain embodiments, the disclosure relates to isolated nucleic acids encoding these polypeptide conjugates, vectors comprising nucleic acid encoding polypeptide conjugates, and protein expression systems comprising these vectors such as infectious viral particles and host cells comprising such nucleic acids.
    Type: Grant
    Filed: October 2, 2018
    Date of Patent: July 6, 2021
    Assignees: Emory University, Children's Healthcare of Atlanta, Inc.
    Inventors: Jacques Galipeau, Jiusheng Deng
  • Patent number: 11046750
    Abstract: This disclosure relates to recombinant or chimeric FVIII proteins, variants, and vectors encoding the proteins containing one or more ancestral mutations. In certain embodiments, one or more protein domains comprise amino acid sequences that are derived from ancestrally reconstructed amino acid sequences. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising the proteins or vectors and related methods of inducing blood clotting.
    Type: Grant
    Filed: May 14, 2020
    Date of Patent: June 29, 2021
    Assignees: Emory University, Georgia Tech Research Corporation
    Inventors: H. Trent Spencer, Christopher B. Doering, Philip M. Zakas, Eric Gaucher
  • Patent number: 11045474
    Abstract: Compounds, compositions, and methods of treatment and prevention of HIV infection are disclosed. The compounds are pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidine JAK inhibitors. Combinations of these JAK inhibitors and additional antiretroviral compounds, such as NRTI, NNRTI, integrase inhibitors, entry inhibitors, protease inhibitors, and the like, are also disclosed. In one embodiment, the combinations include a combination of adenine, cytosine, thymidine, and guanine nucleoside antiviral agents, optionally in further combination with at least one additional antiviral agent that works via a different mechanism than a nucleoside analog. This combination has the potential to eliminate the presence of HIV in an infected patient.
    Type: Grant
    Filed: March 12, 2020
    Date of Patent: June 29, 2021
    Assignees: Emory University, The United States Government as Repersentative by the Department of Veterans Affairs
    Inventors: Christina Gavegnano, Raymond F. Schinazi
  • Patent number: 11027103
    Abstract: Various embodiments of the present invention provide a conduit device including an attaching device configured for defining a helical pathway through a tissue wall and complementary ring in cooperation for securing the device within an aperture defined in the tissue wall. Some embodiments of the present invention further provide a system for implanting a conduit device in a tissue wall. More specifically, some embodiments provide a system including a coring device for defining an aperture in a tissue by removing and retaining a tissue core and securely implanting a conduit device therein so as to provide fluid communication between a first and second surface of the tissue wall via the conduit device.
    Type: Grant
    Filed: March 13, 2018
    Date of Patent: June 8, 2021
    Assignees: Emory University, Georgia Tech Research Corporation
    Inventors: Thomas A. Vassiliades, Ajit Yoganathan, Jorge Heman Jimenez
  • Patent number: 11026913
    Abstract: This disclosure relates to nutritional formulas and uses for treating or preventing a gastrointestinal condition and/or motor-planning speech and/or coordinator difficulties. In certain embodiments, this disclosure relates to a nutritional formula comprising medium 5 chain fatty acids, or esters thereof (such as and tri-, di-, mono-glycerides, or alkyl esters), unsaturated fatty acids, and a vitamin E and optionally other nutrients. In certain embodiments, any of the compounds or nutrients may be in alternative salt forms.
    Type: Grant
    Filed: September 4, 2014
    Date of Patent: June 8, 2021
    Assignees: Emory University, Children's Healthcare of Atlanta, Inc.
    Inventor: Claudia R. Morris
  • Patent number: 11020430
    Abstract: This disclosure relates to the genetic modification of DNMT3A gene in immune cells. In certain embodiments, the modified immune cells may be used in adoptive T cells therapies to enhance immune responses against cancer or chronic infections. In certain embodiments, the disclosure relates to deleting, changing, or inserting nucleotides within the DNMT3A gene in immune cells, e.g., human CD8 T cells, such that the DNMT3A gene product does not function for methylation. In certain embodiments, modification of the DNMT3A gene provides an improvement in antigen-specific T cells functions and/or an enhancement of the longevity of the cells.
    Type: Grant
    Filed: November 4, 2016
    Date of Patent: June 1, 2021
    Assignees: Emory University, St. Jude Children's Research Hospital, Inc.
    Inventors: Rafi Ahmed, Benjamin Youngblood
  • Patent number: 11020379
    Abstract: This disclosure relates to methods of treating or preventing cystic fibrosis transmembrane conductance regulator (CFTR) mediated diseases such as cystic fibrosis, chronic obstructive pulmonary disease, chronic pancreatitis, chronic bronchitis, asthma, mucus formation, comprising administering an effective amount of a 3-(phenyl)-N-(4-phenoxybenzyl)-1,2,4-oxadiazole-5-carboxamide compound, salt, or derivative thereof to a subject in need thereof. In certain embodiments, the 2-amino-N?-benzylidene-acetohydrazide compound is 3-(3,5-dibromo-4-hydroxyphenyl)-N-(4-phenoxybenzyl)-1,2,4-oxadiazole-5-carboxamide.
    Type: Grant
    Filed: November 27, 2019
    Date of Patent: June 1, 2021
    Assignees: Emory University, Children's Healthcare of Atlanta, Inc.
    Inventors: Nael McCarty, Guiying Cui
  • Publication number: 20210128751
    Abstract: Disclosed herein are recombinant viral vectors comprising a liver specific promotor in operable combination with a heterologous nucleic acid sequence encoding a protein, such as a clotting factor. Methods of treating a subject with a clotting disorder, such as hemophilia A or hemophilia B, are also provided.
    Type: Application
    Filed: January 6, 2021
    Publication date: May 6, 2021
    Applicants: Emory University, Children's Healthcare of Atlanta, Inc.
    Inventors: Christopher B. Doering, H. Trent Spencer, Harrison C. Brown
  • Patent number: 10987419
    Abstract: In some embodiments, described herein is a method of tumor treatment or tumor vaccination. The method generally comprises applying to a human being in need thereof a tumor therapeutic composition or tumor vaccine defined herein. The tumor therapeutic composition or tumor vaccine can be produced by protein transfer of glycosyl-phosphatidylinositol (GPI)-anchored immunostimulatory or costimulatory molecules.
    Type: Grant
    Filed: December 6, 2017
    Date of Patent: April 27, 2021
    Assignee: Emory University
    Inventor: Periasamy Selvaraj
  • Patent number: 10975574
    Abstract: In a mechanism for recycling energy from stairs (200), a step platform (210) is moveable between an upper and lower position. An energy storage device (220), coupled to the platform (210), stores energy when a downward force is applied thereto, causing the step platform (210) to move to the lower position. The energy storage device (220) also releases stored energy as the step platform (210) moves from to the upper position. A controllable locking mechanism (240) locks the step platform (210) in the lower position when the downward force has caused the step platform (210) to move into the lower position. A sensor (250) determines when a downward force has been applied to the next higher step platform (250). A controller (300) signals the controllable locking mechanism (242) to unlock the step platform (250) when the step platform (250) is in the lower position and when the downward force has been applied to the next higher step platform (250).
    Type: Grant
    Filed: May 23, 2018
    Date of Patent: April 13, 2021
    Assignees: Georgia Tech Research Corporation, Emory University
    Inventors: Cheng-Yun Karen Liu, Sehoon Ha, Yun Seong Song, Lena Ting
  • Patent number: 10975164
    Abstract: This disclosure relates to diagnostic assays useful to detect a carcinoma from a sample and antibodies or binding fragments thereof useful in the diagnostic tests. In certain embodiments, this disclosure relates to antibodies or fragments that bind HCA, epiglycanin, and/or fragments thereof. In certain embodiments, this disclosure relates to anti-idiotypic antibodies or fragments that bind the variable regions of antibodies that bind HCA and/or epiglycanin.
    Type: Grant
    Filed: February 26, 2019
    Date of Patent: April 13, 2021
    Assignee: Emory University
    Inventors: John Codington, Priscilla Davidson, Priscilla Agbenyefia
  • Patent number: 10945709
    Abstract: Systems, methods, and computer-readable storage media relate to generate an integrated image based on strain data and elastic model. The method may include determining, by a processor, a range of probe positions for placement of an ultrasound probe with respect to a patient based on strain data, the range of positions including a first position, a second position, and one or more positions there between. The method may also include acquiring 3D TRUS images of the patient at each of the one or more positions of the range and generating a patient specific biomechanical model based on the 3D TRUS images. The method may further include integrating the patient specific biomechanical model, the 3D TRUS images and MR images to generate an integrated image of the prostate. The methods, systems, and computer readable media can improve efficiency and accuracy of 3D TRUS and MR image registration, e.g., for image-guided interventions.
    Type: Grant
    Filed: February 22, 2016
    Date of Patent: March 16, 2021
    Assignee: Emory University
    Inventors: Xiaofeng Yang, Tian Liu
  • Patent number: 10947225
    Abstract: This disclosure relates to phosphoinositide 3-kinases (PI3Ks) inhibitors such as N-(5-(imidazo[1,2-a]pyridin-6-yl)pyridin-3-yl)sulfonamide derivatives and uses related thereto. In certain embodiments, the disclosure relates to methods of treating PI3K associated diseases or conditions comprising administering an effective amount of a compound disclosed herein to a subject in need thereof. In certain embodiments, the subject is at risk of, exhibiting symptoms of, suffering from, or diagnosed with cancer or a hematological malignancy.
    Type: Grant
    Filed: May 11, 2017
    Date of Patent: March 16, 2021
    Assignee: Emory University
    Inventors: Qi Shi, Thomas Kaiser, John DiRaddo, James Snyder, Dennis Liotta, Zackery Dentmon
  • Publication number: 20210065908
    Abstract: An electronic processing system agent accesses population health literacy data from a population of at least 100 individuals pertaining to assessed health literacy of members of the population, and demographic data from the population corresponding to age, race, and level of education. The agent collects skills data from the patient corresponding to a set of questions presented to the patient relating to skills needed for understanding therapeutic instructions, as well as personal data relating to the age, race, and level of education of the patient.
    Type: Application
    Filed: January 11, 2019
    Publication date: March 4, 2021
    Applicants: Nova Southeastern University, Emory University
    Inventors: Raymond L. Ownby, Amarilis Acevedo, Drenna Waldrop-Valverde