Patents Assigned to Emory University
  • Methods for using water-stabilized organosilanes
    Patent number: 6632805
    Abstract: A method of dyeing and treating a substrate using a water-stabilized organosilane. A method of antimicrobially treating a food article. A method of antimicrobially coating a fluid container. A method of antimicrobially coating a latex medical article.
    Type: Grant
    Filed: May 7, 1996
    Date of Patent: October 14, 2003
    Assignee: Emory University
    Inventors: Lanny S. Liebeskind, Gary D. Allred
  • Human mitogenic oxidase
    Patent number: 6620603
    Abstract: The present invention relates to new genes encoding for the production of novel proteins involved in generation of reactive oxygen intermediates that affect cell division. The present invention also provides vectors containing these genes, cells transfected with these vectors, antibodies raised against these novel proteins, kits for detection, localization and measurement of these genes and proteins, and methods to determine the activity of drugs to affect the activity of the proteins of the present invention.
    Type: Grant
    Filed: November 10, 1999
    Date of Patent: September 16, 2003
    Assignee: Emory University
    Inventors: J. David Lambeth, Kathy K. Griendling, Bernard P. Lassegue, Rebecca S. Arnold, Guangjie Cheng
  • Automated planning volume contouring algorithm for adjuvant brachytherapy treatment planning in sarcoma
    Patent number: 6615070
    Abstract: A mathematical contouring algorithm that automatically determines the planning volume of a sarcoma prior to designing a brachytherapy treatment plan. The algorithm, utilizing computational geometry, numerical interpolation and artificial intelligence (AI) techniques, returns the planning volume in digitized and graphical forms in a matter of minutes. Such an automatic procedure reduces labor time and provides a consistent and objective method for determining planning volumes. In addition, a definitive representation of the planning volume allows for sophisticated brachytherapy treatment planning approaches to be applied when designing treatment plans, so as to maximize local tumor control and minimize normal tissue complications.
    Type: Grant
    Filed: June 1, 2001
    Date of Patent: September 2, 2003
    Assignees: Georgia Tech Research Corporation, Emory University
    Inventor: Eva K. Lee
  • Sphingolipid derivatives and their methods of use
    Patent number: 6610835
    Abstract: Derivatives of sphingolipids of the formula: are provided wherein the substituents are as defined in the specification and wherein there is at least one R2 substituent in the sphingolipid derivative. The compounds are useful in the treatment of of abnormal cell proliferation, including benign and malignant tumors, the promotion of cell differentiation, the induction of apoptosis, the inhibition of protein kinase C, and the treatment of inflammatory conditions, psoriasis, inflammatory bowel disease as well as proliferation of smooth muscle cells in the course of development of plaques in vascular tissue. The invention also includes a method for triggering the release of cytochrome c from mitochondria that includes administering an effective amount of a sphingolipid or its derivative or prodrug to a host in need thereof.
    Type: Grant
    Filed: February 12, 1999
    Date of Patent: August 26, 2003
    Assignee: Emory University
    Inventors: Dennis C. Liotta, Alfred H. Merrill, Jr., Thomas E. Keane, Kapil N. Bhalla, Eva M Schmelz
  • 3?-azido-2?,3?-dideoxyuridine in an anti-HIV effectiveness test protocol
    Patent number: 6602664
    Abstract: It has been discovered that 3′-azido-2′,3′-dideoxyuridine (CS-87) induces a transient mutation in HIV-1 at the 70th codon (K to R, i.e., lysine to arginine) of the reverse transcriptase region of the virus. Based on this discovery, a method and composition for treating HIV is provided that includes administering CS-87 or its pharmaceutically acceptable salt or prodrug to a human in need of therapy in combination or alternation with a drug that induces a mutation in HIV-1 at a location other than the 70th codon of the reverse transcriptase region. This invention can be practiced by referring to the published mutation patterns for known anti-HIV drugs, or by determining the mutation pattern for a new drug.
    Type: Grant
    Filed: February 26, 2001
    Date of Patent: August 5, 2003
    Assignees: Emory University, Idenix Pharmaceuticals, Inc.
    Inventors: Raymond F. Schinazi, Martin L. Bryant, Maureen W. Myers
  • Isolated nucleic acid molecule encoding a variant human eukaryotic Intiation Factor 4E protein
    Patent number: 6596854
    Abstract: The invention provides a method of purifying human eIF-4E protein and amino acid sequence variants thereof having altered binding affinity for capped RNA. Using the described purification, amino acid sequence variants can readily be expressed, purified and tested. Both lowered and enhanced binding affinity variants are useful for modifying protein expression levels in vivo and in vitro.
    Type: Grant
    Filed: April 14, 2001
    Date of Patent: July 22, 2003
    Assignee: Emory University
    Inventors: Curt H. Hagedorn, Taly Spivak-Kroizman, Yiping Xie
  • Compositions and methods for the expression of factor VIII polypeptides and uses therefor
    Publication number: 20030129174
    Abstract: Compositions and methods are provided for the in vivo gene delivery of nucleic acid sequences encoding the factor VIII protein to the liver endothelial sinusoidal cells (LSECs). Compositions and methods are also provided for the ex vivo gene transfer of nucleic acid sequences encoding the factor VIII protein to cultured LSECs and the implantation of the transformed LSECs in vivo. These methods and compositions increase the level of factor VIII in the blood stream and find use in the gene therapy treatment of hemophilia A.
    Type: Application
    Filed: December 3, 2002
    Publication date: July 10, 2003
    Applicant: Emory University
    Inventors: John S. Lollar, Hung V. Do, John F. Healey, Edmund K. Waller
  • Synthesis, anti-human immunodeficiency virus, and anti-hepatitis B virus activities of 1,3-oxaselenolane nucleosides
    Patent number: 6590107
    Abstract: A method and composition for the treatment of HIV infection, HBV infection, or abnormal cellular proliferation in humans and other host animals is disclosed that includes the administration of an effective amount of a 1,3-oxaselenolane nucleoside or a pharmaceutically acceptable salt thereof, optionally in a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: March 5, 2001
    Date of Patent: July 8, 2003
    Assignees: Emory University, The University of Georgia Research Foundation, Inc.
    Inventors: Raymond F. Schinazi, Chung K. Chu, Jinfa Du
  • Modular cytomimetic biomaterials, transport studies, preparation and utilization thereof
    Patent number: 6583251
    Abstract: The present invention provides a biocompatible material, comprising a phospholipid or phospholipid derivative comprising various functional groups having specific chemical properties, which can function as a modular surface design unit to be incorporated or appended to a desired substrate on which it is then polymerized, thereby contributing new or specified biochemical characteristics to the polymerized and stabilized biomaterial.
    Type: Grant
    Filed: June 30, 1999
    Date of Patent: June 24, 2003
    Assignee: Emory University
    Inventors: Elliot L. Chaikof, Kacey G. Marra, John H. Chon
  • Method for the esterification of alcohols and compounds useful therefor as potential anticancer agents
    Patent number: 6583292
    Abstract: Described herein is a method for preparing an ester by (a) admixing a compound having the formula I: with a base to form an intermediate, and (b) admixing the intermediate produced in step (a) with a compound composed of an alcohol, an alkoxide, or a combination thereof, wherein steps (a) and (b) are performed in situ.
    Type: Grant
    Filed: February 6, 2002
    Date of Patent: June 24, 2003
    Assignee: Emory University
    Inventors: Dennis C. Liotta, Hariharan Venkatesan, Laura Captain, Michael V. Voronkov, James P. Snyder, Marcus A. Schestopol
  • Nucleosides and oligonucleotides containing boron clusters
    Patent number: 6583122
    Abstract: Carboranyl-containing nucleosides and oligonucleotides are provided for use in boron neutron capture therapy (BNCT) and for other therapeutic and diagnostic purposes.
    Type: Grant
    Filed: January 30, 2001
    Date of Patent: June 24, 2003
    Assignee: Emory University
    Inventors: Raymond F. Schinazi, Geraldiné Fulcrand-El Kattan, Zbigniew Jan Lesnikowski
  • Methods and devices for ex vivo irradiation of autologous coronary bypass conduit
    Patent number: 6575898
    Abstract: Fibrointimal proliferation, neointimal hyperplasia and other vascular lesions or injuries are reduced by ex vivo irradiation of the autologous coronary bypass conduit, especially the saphenous vein, as an adjunct in cardiovascular surgery or other treatment, in anyone of a variety of suitable devices.
    Type: Grant
    Filed: November 1, 2001
    Date of Patent: June 10, 2003
    Assignee: Emory University
    Inventor: Robin G. Smith
  • Holographic, laser-induced fabrication of indium nitride quantum wires and quantum dots
    Patent number: 6558995
    Abstract: A semiconductor device is constructed of at least one indium nitride or indium nitride alloy nanostructure on a substrate or other thing film layer. The method used to create the semiconductor device involves illuminating the substrate with a lateral intensity patterning of ultraviolet light in the presence of at least hydrazoic acid and a compound containing indium gas flows. Additionally, a semiconductor light-emitting/detecting modulating device composed of at least one indium nitride or indium nitride alloy nanostructure. The method used to create the semiconductor light-emitting/detecting modulating device involves embedding at least one nanostructure in the interior layer of the device. Further, a monolithic photovoltaic-photoelectrochemical device where one layer is composed of an indium nitride or indium nitride alloy film or nanostructure.
    Type: Grant
    Filed: April 27, 2001
    Date of Patent: May 6, 2003
    Assignee: Emory University
    Inventors: Guy D. Gilliland, Ming-Chang Lin
  • Regulation of apoptosis and in vitro model for studies thereof
    Patent number: 6558900
    Abstract: A cell-free system based on the cytosol of normally growing cells, which reproduces measurable aspects of the apoptotic program, is provided. The apoptotic program is initiated by addition of DATP in the specific exemplification of the HeLa 100,000×g supernatant. Fractionation of the cytosol yielded a 15 kDa protein, identified by absorption spectrum and protein sequence as cytochrome c, that is required for in vitro apoptosis. Elimination of cytochrome c from cytosol by immunodepletion or inclusion of sucrose to stabilize mitochondria during cytosol preparation, diminished the apoptotic activity. Addition of exogenous cytochrome c to cytochrome c-depleted extracts restored apoptotic activity. Cells undergoing apoptosis in vivo showed increased release of cytochrome c to their cytosol, suggesting that mitochondria may function in apoptosis by releasing cytochrome c.
    Type: Grant
    Filed: July 11, 1997
    Date of Patent: May 6, 2003
    Assignee: Emory University
    Inventors: Xiaodong Wang, Xuesong Liu
  • Diimino-piperazine derivatives for use as modulators of cell regulation
    Patent number: 6552025
    Abstract: Compositions, methods of use, isolation and biosynthesis of diimino-piperazine derivatives useful for the modification of sphingolipid metabolism and other biological functions are described. The preferred derivative is 2,6-bis-(&ohgr;-aminobutyl)-3,5-diimino-piperazine. This is a naturally occurring biochemical compound isolated from cells. The diimino-piperazine derivatives are useful as therapeutic agents when administered to patients to treat diseases and disorders involving cell regulation.
    Type: Grant
    Filed: November 17, 2000
    Date of Patent: April 22, 2003
    Assignee: Emory University
    Inventors: Alfred H. Merrill, Jr., Lisa Warden, Dennis C. Liotta
  • Magnetic stimulation coil and circuit design
    Patent number: 6527695
    Abstract: The invention is a method for nerve cell stimulation wherein optimal frequency of a coupled magnetic circuit, optimal reluctance of a coupled magnetic circuit, optimal capacitance of a coupled magnetic circuit, and optimal winding resistance of a coupled magnetic circuit for construction of a magnetic nerve stimulator are selected to maximize stimulation of a nerve cell. The maximization of the nerve stimulation is achieved by maximizing the membrane voltage.
    Type: Grant
    Filed: September 29, 2000
    Date of Patent: March 4, 2003
    Assignee: Emory University
    Inventors: Kent R. Davey, Charles Epstein
  • Protein phosphatase methylesterase
    Patent number: 6528295
    Abstract: Carboxymethylation of proteins is a highly conserved means of regulation in eukaryotic cells. The protein phosphatase 2A (PP2A) catalytic (C) subunit is reversibly methylated at its carboxy-terminus by specific methylesterase. Carboxymethylation affects PP2A activity and varies during the cell cycle. The present disclosure provides the coding sequence of a methylesterase, herein named Protein Phosphatase Methylesterase-1 (PME-1). PME-1 is highly conserved from yeast to human and contains a motif found in lipases, which motif has a catalytic triad-activated serine as the active site nucleophile. Recombinant PME-1 polypeptide produced in bacteria demethylates PP2A C subunit in vitro and okadaic acid, a known inhibitor of the PP2A methylesterase, inhibited this reaction. PME-1 represents the first mammalian protein phosphatase methylesterase cloned to date.
    Type: Grant
    Filed: April 20, 2001
    Date of Patent: March 4, 2003
    Assignee: Emory University
    Inventors: David C. Pallas, Xian X. Du
  • N-protected synthesis method for use in making porphyrins
    Patent number: 6528659
    Abstract: One aspect of the present invention relates to a method of forming chemical compounds and, in particular, chemical intermediates having one or more pyrrole sub-units and at least one protecting group bonded to an atom within a pyrrole sub-unit. The method further involves removal of the protecting group so as to provide a desired chemical compound having one or more pyrrole sub-units. The method can be employed in making porphyrin compounds.
    Type: Grant
    Filed: March 13, 2000
    Date of Patent: March 4, 2003
    Assignee: Emory University
    Inventors: Eric G. Nickel, Lanny S. Liebeskind
  • Nucleosides with anti-hepatitis B virus activity
    Patent number: 6525033
    Abstract: A method for treating HBV infections via administration of 2′, 3′ dideoxynucleoside compounds.
    Type: Grant
    Filed: November 22, 1999
    Date of Patent: February 25, 2003
    Assignees: Emory University, University of Alabama Research Foundation, Inc.
    Inventors: Raymond F. Schinazi, Jean-Pierre Sommadossi, Gilles Gosselin, Jean-Louis Imbach
  • Compositions and methods for the expression of factor VIII polypeptides and uses therefor
    Patent number: 6517830
    Abstract: Compositions and methods are provided for the in vivo gene delivery of nucleic acid sequences encoding the factor VIII protein to the liver endothelial sinusoidal cells (LSECs). Compositions and methods are also provided for the ex vivo gene transfer of nucleic acid sequences encoding the factor VIII protein to cultured LSECs and the implantation of the transformed LSECs in vivo. These methods and compositions increase the level of factor VIII in the blood stream and find use in the gene therapy treatment of hemophilia A.
    Type: Grant
    Filed: August 4, 2000
    Date of Patent: February 11, 2003
    Assignee: Emory University
    Inventors: John S. Lollar, Hung V. Do, John F. Healey, Edmund K. Waller