Abstract: Compositions including small molecule mitofusin activators are described. The mitofusin activators are useful for treating diseases or disorders associated with a mitochondria-associated disease, disorder, or condition such as diseases or disorders associated with mitofusin 1 (MFN1) and/or mitofusin 2 (MFN2), or mitochondrial dysfunction. Methods of treatment, pharmaceutical formulations, and screening methods for identifying compounds that activate mitochondrial fusion are also described.

Abstract: Compositions including small molecule mitofusin activators are described. The mitofusin activators are useful for treating diseases or disorders associated with a mitochondria-associated disease, disorder, or condition such as diseases or disorders associated with mitofusin 1 (MFN1) and/or mitofusin 2 (MFN2), or mitochondrial dysfunction. Methods of treatment, pharmaceutical formulations, and screening methods for identifying compounds that activate mitochondrial fusion are also described.

Abstract: Compounds and compositions including stereoisomers of 6-phenylhexanamide derivative small molecule mitofusin activators are described. In particular, mitofusin activators comprising derivatives of (trans-4-hydroxycyclohexyl)-6-phenylhexanamide, which are useful for treating diseases or disorders associated with a mitochondria-associated disease, disorder, or condition such as diseases or disorders associated with mitofusin-1 (MFN1) and/or mitofusin-2 (MFN2), or mitochondrial dysfunction, are described. Methods of treatment and pharmaceutical formulations are also described.

Abstract: Compounds and compositions including stereoisomers of 6-phenylhexanamide derivative small molecule mitofusin activators are described. In particular, mitofusin activators comprising derivatives of (trans-4-hydroxycyclohexyl)-6-phenylhexanamide, which are useful for treating diseases or disorders associated with a mitochondria-associated disease, disorder, or condition such as diseases or disorders associated with mitofusin-1 (MFN1) and/or mitofusin-2 (MFN2), or mitochondrial dysfunction, are described. Methods of treatment and pharmaceutical formulations are also described.

Abstract: Compositions including small molecule mitofusin activators are described. The mitofusin activators are useful for treating diseases or disorders associated with a mitochondria-associated disease, disorder, or condition such as diseases or disorders associated with mitofusin 1 (MFN1) and/or mitofusin 2 (MFN2), or mitochondrial dysfunction. Methods of treatment, pharmaceutical formulations, and screening methods for identifying compounds that activate mitochondrial fusion are also described.

Abstract: Compositions including small molecule mitofusin activators are described. The mitofusin activators are useful for treating diseases or disorders associated with a mitochondria-associated disease, disorder, or condition such as diseases or disorders associated with mitofusin 1 (MFN1) and/or mitofusin 2 (MFN2), or mitochondrial dysfunction. Methods of treatment, pharmaceutical formulations, and screening methods for identifying compounds that activate mitochondrial fusion are also described.

Abstract: Compositions including small molecule mitofusin activators are described. The mitofusin activators are useful for treating diseases or disorders associated with a mitochondria-associated disease, disorder, or condition such as diseases or disorders associated with mitofusin 1 (MFN1) and/or mitofusin 2 (MFN2), or mitochondrial dysfunction. Methods of treatment, pharmaceutical formulations, and screening methods for identifying compounds that activate mitochondrial fusion are also described.

Abstract: Compounds and compositions including stereoisomers of 6-phenylhexanamide derivative small molecule mitofusin activators are described. In particular, mitofusin activators comprising derivatives of (trans-4-hydroxycyclohexyl)-6-phenylhexanamide, which are useful for treating diseases or disorders associated with a mitochondria-associated disease, disorder, or condition such as diseases or disorders associated with mitofusin-1 (MFN1) and/or mitofusin-2 (MFN2), or mitochondrial dysfunction, are described. Methods of treatment and pharmaceutical formulations are also described.

Abstract: A method for adaptive voice interaction includes monitoring voice communications between a service recipient and a service representative, measuring a set of voice communication features based upon the voice communications between the service recipient and the service representative, analyzing the set of voice communication features to generate emotion metric values, and generating a response based on the analysis of the set of voice communication features.

Abstract: A computerized method, software, and system for recognizing emotions from a speech signal, wherein statistical and MFCC features are extracted from the speech signal, the MFCC features are sorted to provide a basis for comparison between the speech signal and reference samples, the statistical and MFCC features are compared between the speech signal and reference samples, a scoring system is used to compare relative correlation to different emotions, a probable emotional state is assigned to the speech signal based on the scoring system and the probable emotional state is communicated to a user.

Abstract: A computerized method, software, and system for recognizing emotions from a speech signal, wherein statistical and MFCC features are extracted from the speech signal, the MFCC features are sorted to provide a basis for comparison between the speech signal and reference samples, the statistical and MFCC features are compared between the speech signal and reference samples, a scoring system is used to compare relative correlation to different emotions, a probable emotional state is assigned to the speech signal based on the scoring system and the probable emotional state is communicated to a user.

Abstract: A computerized method, software, and system for recognizing emotions from a speech signal, wherein statistical and MFCC features are extracted from the speech signal, the MFCC features are sorted to provide a basis for comparison between the speech signal and reference samples, the statistical and MFCC features are compared between the speech signal and reference samples, a scoring system is used to compare relative correlation to different emotions, a probable emotional state is assigned to the speech signal based on the scoring system, and the probable emotional state is communicated to a user.

Abstract: A system stores digital media records and has a search engine searching the stored digital media records. The system receives first search requests from a plurality of first users. The system performs, by the search engine, searches based upon the first search requests, yielding respective first search results, each first search result defining first selected digital media records. The first search results are logged. Information is received from the first users indicative of subsequent actions by the first users selecting particular ones of the selected digital media records. A second search request is received from a second user. A search is performed, by the search engine, based upon the second search request, yielding respective second search results, the second search results defining second selected digital media records. The second selected media records are then ranked differently, for example upward or downward, based upon the longed first search results.

Abstract: A system stores digital media records, and comprising a vocabulary file of words keyed to the digital media records. A search query is received by computer from a user, the search query including words. The search query is logged by computer, yielding a query log. The query log is processed by computer to identify words in the query log which are not words already included in the vocabulary file and which are not words which are variants of words already included in the vocabulary file. Such words are defined as “not-found words.” The not-found words are added to the vocabulary file, and the not-found words are keyed to the digital media records.

Abstract: A system has first and second metadata streams with respect to a video stream, the first metadata stream time-coded with respect to the video stream and the second metadata stream not time-coded with respect to the video stream. The the second metadata stream is aligned with the first metadata stream. Time ccodes are added to the second metadata stream, based on the alignment. Proper names are searched for within the second metadata stream. Faces are found within the video stream, faces are matched with proper names, and the matched faces and proper names are placed into a reference library.

Abstract: The software incorporates a glossary management tool that makes it easy for each client to customize terminology to the needs of a particular business. With this tool, termed a glossary manager, a company can customize a number of feature names in the system to provide a more familiar context for their users. A system administrator can also customize the manner in which “thumbnail” or “preview” images are presented. The system performs clustering on search queries, and searches media records multi-modally, using two or more approaches such as image searching and text searching. An administrator can tune search parameters. Two or more streams of metadata may be aligned and correlated with a media file, facilitating later searching. The system evaluates itself. It folds popularity information into rankings of search results.

Abstract: The software according to the invention incorporates a glossary management tool that makes it easy for each client to customize terminology to the needs of a particular business. With this tool, termed a glossary manager, a company can customize a number of feature names in the system to provide a more familiar context for their users. A system administrator can also customize the manner in which “thumbnail” or “preview” images are presented. The system performs clustering on search queries, and searches media records multi-modally, using two or more approaches such as image searching and text searching. An administrator can tune search parameters. Two or more streams of metadata may be aligned and correlated with a media file, facilitating later searching. The system evaluates itself. It folds popularity information into rankings of search results.

Abstract: The software according to the invention incorporates a glossary management tool that makes it easy for each client to customize terminology to the needs of a particular business. With this tool, termed a glossary manager, a company can customize a number of feature names in the system to provide a more familiar context for their users. A system administrator can also customize the manner in which “thumbnail” or “preview” images are presented. The system performs clustering on search queries, and searches media records multi-modally, using two or more approaches such as image searching and text searching. An administrator can tune search parameters. Two or more streams of metadata may be aligned and correlated with a media file, facilitating later searching. The system evaluates itself. It folds popularity information into rankings of search results.

Abstract: The software according to the invention incorporates a glossary management tool that makes it easy for each client to customize terminology to the needs of a particular business. With this tool, termed a glossary manager, a company can customize a number of feature names in the system to provide a more familiar context for their users. A system administrator can also customize the manner in which “thumbnail” or “preview” images are presented. The system performs clustering on search queries, and searches media records multi-modally, using two or more approaches such as image searching and text searching. An administrator can tune search parameters. Two or more streams of metadata may be aligned and correlated with a media file, facilitating later searching. The system evaluates itself. It folds popularity information into rankings of search results.

Abstract: The software according to the invention incorporates a glossary management tool that makes it easy for each client to customize terminology to the needs of a particular business. With this tool, termed a glossary manager, a company can customize a number of feature names in the system to provide a more familiar context for their users. A system administrator can also customize the manner in which “thumbnail” or “preview” images are presented. The system performs clustering on search queries, and searches media records multi-modally, using two or more approaches such as image searching and text searching. An administrator can tune search parameters. Two or more streams of metadata may be aligned and correlated with a media file, facilitating later searching. The system evaluates itself. It folds popularity information into rankings of search results.