Abstract: A hypodermic syringe is provided which comprises a hollow barrel, a longitudinally slidable and axially rotatable plunger shaft, a sealing means, e.g., a self-resealing rubber cap or sealing gasket, and an integrally-joined cover which includes (i) a charging positioning means for longitudinally moving the shaft within the barrel, (ii) axial rotational means for rotating the shaft of about 180.degree. to a plurality of discharge positions, and (iii) discharging positioning means for longitudinally moving the shaft within the barrel. The hypodermic syringe can only be used once to inject a patient or user with a liquid.