Abstract: The present invention describes novel and improved dosage forms containing fluticasone propionate for the treatment of conditions associated with inflammation of the esophagus.
Abstract: The present invention describes novel and improved dosage forms containing fluticasone propionate for the treatment of conditions associated with inflammation of the esophagus.
Abstract: A delivery system for water-insoluble pharmaceutical active ingredients is provided. The delivery system includes water-insoluble pharmaceutical active ingredient(s), organic solvent(s) and amphiphilic co-solvent(s), and a mixture of hydrophilic and hydrophobic non-ionic surfactants. Upon dilution in an aqueous medium, this formulation forms spontaneously dispersion of non-ionic surfactant nanoparticles.
Type:
Grant
Filed:
August 11, 2008
Date of Patent:
March 8, 2016
Assignee:
EMS S/A
Inventors:
Flavia Giuliana Tinti, Marcia Cristina Breitkreitz, Carlo Oliani
Abstract: The present invention relates to compounds derived from taurine with non-steroidal anti inflammatory activity. In a first embodiment, the present invention relates to compounds derived from taurine, in which taurine is bound directly by means of an amide bond or through an spacing group, to a compound selected from the group of non-steroidal anti inflammatory compounds, cited as derived from taurine presenting the Formula (I): in which R means the component with non-steroidal anti inflammatory activity. In a second embodiment, the invention provides a process for obtaining the compounds of Formula (I) by reaction of taurine with a compound belonging to the group of non-steroidal anti inflammatory (NSAIs), in order to obtain a compound derived from taurine by direct bond or through a spacing group of the taurine to the NSAI. The invention also relates to the pharmaceutical compositions comprising at least one compound derived from taurine presenting non-steroidal anti inflammatory activity.
Type:
Application
Filed:
September 24, 2013
Publication date:
February 27, 2014
Applicants:
UNIVERSIDADE ESTADUAL PAULISTA JULIO DE MESQUITA FILHO - UNESP, EMS S.A.
Inventors:
Ednir de Oliveira VIZIOLI, Chung Man Chin, Renato Farina Menegon, Lorena Blau, Jean Leandro Dos Santos, Maria do Carmo Longo
Abstract: The present invention relates to compounds derived from taurine with non-steroidal anti inflammatory activity. In a first embodiment, the present invention relates to compounds derived from taurine, in which taurine is bound directly by means of an amide bond or through an spacing group, to a compound selected from the group of non-steroidal anti inflammatory compounds, cited as derived from taurine presenting the Formula (I): in which R means the component with non-steroidal anti inflammatory activity. In a second embodiment, the invention provides a process for obtaining the compounds of Formula (I) by reaction of taurine with a compound belonging to the group of non-steroidal anti inflammatory (NSAIs), in order to obtain a compound derived from taurine by direct bond or through a spacing group of the taurine to the NSAI. The invention also relates to the pharmaceutical compositions comprising at least one compound derived from taurine presenting non-steroidal anti inflammatory activity.
Type:
Grant
Filed:
April 9, 2009
Date of Patent:
October 29, 2013
Assignees:
EMS S.A., Universidade Estadual Paulista Julio de Mesquinta Filho—UNESP
Inventors:
Ednir D. Vizioli, Chung M. Chin, Renato F. Menegon, Lorena Blau, Jean L. Santos, Maria D. Longo
Abstract: A delivery system for water-insoluble pharmaceutical active ingredients is provided. The delivery system includes water-insoluble pharmaceutical active ingredient(s), organic solvent(s) and amphiphilic co-solvent(s), and a mixture of hydrophilic and hydrophobic non-ionic surfactants. Upon dilution in an aqueous medium, this formulation forms spontaneously dispersion of non-ionic surfactant nanoparticles.
Type:
Application
Filed:
August 11, 2008
Publication date:
July 12, 2012
Applicant:
EMS S/A
Inventors:
Flavia Giuliana Tinti, Marcia Cristina Breitreitz, Vladimir Matha, Carlo Oliani
Abstract: The present invention relates to phthalimide derivatives of non-steroidal and/or TNF-? modulating anti-inflammatory compounds as well as the process of obtaining the so-called derivatives, pharmaceutical compositions containing such derivatives and their uses, including use in the treatment of inflammatory diseases, especially those related to chronic inflammatory processes, such as rheumatoid arthritis and intestinal inflammatory diseases (for instance, Chron's disease) and the use of the referred to pharmaceutical compositions as antipyretic, analgesic and platelet antiaggregating medications.
Type:
Application
Filed:
April 7, 2010
Publication date:
May 10, 2012
Applicant:
EMS S.A.
Inventors:
Jean Leandro dos Santos, Ednir de Oliveira Vizioli, Chung Man Chin, Renato Farina Menegon, Lorena Blau
Abstract: This invention refers to pharmaceutical compositions that comprise the mixture of an effective amount of leucine-derivative powders or granules and, at least, one pharmaceutically acceptable excipient substance used as carrier. In particular, the main feature of the pharmaceutical composition is the fact that it is free of preservative agents and might be formulated in any usual pharmaceutical oral formulation.
Type:
Application
Filed:
October 3, 2011
Publication date:
March 29, 2012
Applicant:
EMS S.A.
Inventors:
Flavia Giuliana TINTI, Vladimir Matha, Ricardo Vian Marques
Abstract: The present invention relates to compounds derived from taurine with non-steroidal anti inflammatory activity. In a first embodiment, the present invention relates to compounds derived from taurine, in which taurine is bound directly by means of an amide bond or through an spacing group, to a compound selected from the group of non-steroidal anti inflammatory compounds, cited as derived from taurine presenting the Formula (I): in which R means the component with non-steroidal anti inflammatory activity. In a second embodiment, the invention provides a process for obtaining the compounds of Formula (I) by reaction of taurine with a compound belonging to the group of non-steroidal anti inflammatory (NSAIs), in order to obtain a compound derived from taurine by direct bond or through a spacing group of the taurine to the NSAI. The invention also relates to the pharmaceutical compositions comprising at least one compound derived from taurine presenting non-steroidal anti inflammatory activity.
Type:
Application
Filed:
April 9, 2009
Publication date:
May 19, 2011
Applicants:
EMS S.A., Universidade Estadual Paulista Julio De Mesquita Filho - UNESP
Inventors:
Ednir de Oliveira Vizioli, Chung Man Chin, Renato Farina Menegon, Lorena Blau, Jean Leandro Dos Santos, Maria do Carmo Longo
Abstract: The present application describes nitroimidazolic derivative compounds with antibacterial and/or antiprotozoal activity, which are potent urease inhibitors. It also describes the process for preparing those compounds and their use in pharmaceutical compositions and medicines.
Type:
Grant
Filed:
October 27, 2004
Date of Patent:
October 27, 2009
Assignee:
EMS S.A.
Inventors:
Antônio Silva, Andressa Munhoz, Jean Santos, Rodolfo Camargo, Lúcia Castro, Renato Menegon, Wagner Vilegas, Antonio Ferreira, Eliana Varanda, Man Chin Chung