Abstract: The present invention relates to solid compositions comprising cocrystals of cannabinoids, processes for their preparation, and their use as in therapy or in cosmetics or for the purification of cannabinoids. It also relates to cocrystals of cannabinoids.
Type:
Grant
Filed:
October 31, 2019
Date of Patent:
May 28, 2024
Assignee:
ENANTIA S.L.
Inventors:
Nicolas Tesson, Montserrat Trilla Castaño, Alexander Christian Comely
Abstract: The present invention relates to cocrystals of 2-[(1R,6R)-6-isopropenyl-3-methylcyclohex-2-en-1-yl]-5-pentylbenzene-1,3-diol and a zwitterion coformer, processes for their preparation, and their use as a medicament and for the purification of 2-[(1R,6R)-6-isopropenyl-3-methylcyclohex-2-en-1-yl]-5-pentylbenzene-1,3-diol. The invention also relates to compositions comprising the cocrystal.
Type:
Grant
Filed:
August 6, 2018
Date of Patent:
November 9, 2021
Assignee:
ENANTIA, S.L.
Inventors:
Alexander Christian Comely, Nicolas Tesson, Carmen Jiménez González
Abstract: A process for the preparation of 4,6-dihalopyrimidin-5-amines of formula (II), or salts thereof, which comprises reacting 5-aminopyrimidin-4,6-diols of formula (III), or salts thereof, or a solvate either of the compound of formula (III) or of a salt thereof, with a halogenating agent, new intermediates useful in the preparation of the compound of formula (II) and processes for the preparation of these intermediates. The invention also refers to a process for the preparation of ticagrelor or a pharmaceutically acceptable salt thereof from 4,6-dihalo-2-(propylthio)pyrimidin-5-amine of formula (IIA).
Type:
Application
Filed:
August 5, 2013
Publication date:
June 4, 2015
Applicant:
ENANTIA, S.L.
Inventors:
Mireia Pastó Aguilá, Alexander Christian Comely
Abstract: It comprises a cocrystal of saxagliptin hydrochloride and a compound selected from the group consisting of saxagliptin, glycolic acid, malonic acid, and urea; or a solvate thereof, or a hydrate thereof. It also comprises a salt of saxagliptin with glycolic acid 1:1 hydrate. It also comprises their preparation processes, as well as their use as antidiabetics.
Abstract: The present invention relates to enantiomerically enriched aminodiphosphine ligands where the chirality is located in the phosphorus atom and their preparation process, to catalysts containing them and their preparation process, as well as their use in asymmetric synthesis.
Type:
Application
Filed:
October 13, 2010
Publication date:
December 6, 2012
Applicant:
ENANTIA, S.L.
Inventors:
Mónica Alonso Xalma, Xavier Verdaguer Espaulella, Marc Revés Vilaplana, Antoni Riera Escalé
Abstract: A process for the preparation of rivaroxaban, or a pharmaceutically acceptable salt thereof, or a solvate thereof, including a hydrate, comprising submitting an amine compound of formula (III) wherein R1 is a (C4-C10)-alkyl radical which is attached to the N atom by a tertiary C atom, first to an acylation reaction and then to a dealkylation reaction.
Type:
Application
Filed:
January 3, 2011
Publication date:
November 8, 2012
Applicant:
ENANTIA, S.L.
Inventors:
Llorenç Rafecas Jané, Alexander Christian Comely, Alessandro Ferrali, Celia Amela Cortés, Mireia Pastó Aguilà