Abstract: Provided is a pharmaceutical composition involving a concentrated mixture of a precipitated protein and a liquid medium and a method for manufacturing the concentrated mixture. The concentrated mixture is manufacturable by precipitation of a protein with a biocompatible polymer precipitating agent, followed by removal of sufficient liquid to concentrate the resulting mixture to the desired degree. The precipitated protein can be stored for a significant time in the concentrated mixture, such as intermediate between processing stages during manufacture operations.
Type:
Grant
Filed:
October 16, 2002
Date of Patent:
February 12, 2013
Assignee:
Endo Pharmaceuticals Colorado, Inc.
Inventors:
John F. Carpenter, Jeffrey B. Etter, Adrian C. Samaniego