Patents Assigned to Endocare, Inc.
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Patent number: 11026737Abstract: Embodiments of the present invention relate to cryogenic systems and methods useful to cool objects, including living tissue, to freezing or cryogenic temperatures by placing the object in thermal communication with sub-cooled supercritical nitrogen.Type: GrantFiled: March 14, 2014Date of Patent: June 8, 2021Assignee: Endocare, Inc.Inventors: John G. Baust, John M. Baust, Anthony T. Robilotto
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Patent number: 10952784Abstract: A cryosurgical system including a computer system programmed with software configured to perform the following steps: a) capturing at least one first view of a region of interest in a human body; b) capturing at least one second view of the region of interest; c) outlining the region of interest and at least one area outside the region of interest with the assistance of an operator; d) constructing a 3-dimensional model of the region of interest and the at least one area outside the region of interest utilizing the at least one first view and the at least one second view of the region of interest; and e) utilizing the 3-dimensional model of the region of interest and the at least one area outside the region of interest to determine at least one cryosurgical probe placement location.Type: GrantFiled: August 6, 2017Date of Patent: March 23, 2021Assignee: Endocare, Inc.Inventors: Shenghao Bao, Jay J. Eum
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Patent number: 10835316Abstract: An emitter assembly can include a proximal shaft, a distal shaft, a shunt that connects the proximal shaft to the distal shaft, and a tip that is connected to a distal end of the distal shaft. An inner conductor can extend through the proximal shaft, the shunt, and the distal shaft and into the tip to provide microwave energy to the tip. An outer conductor can extend into the shunt. The shunt can therefore form an electrical connection between the outer conductor and a proximal ring of electrically conductive material formed on an exterior surface of the distal shaft. Distal shaft can be made of a thermally conductive but electrically insulated material to facilitate transfer of heat from the distal shaft to the proximal shaft.Type: GrantFiled: May 14, 2018Date of Patent: November 17, 2020Assignee: Endocare, Inc.Inventors: Chet M. Crump, Kent Moore, Mark Sedlacek, Todd H. Turnlund
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Patent number: 10828105Abstract: A system for assisting a surgeon in placing at least one ablation device into a treatment region of a patient, where the system includes at least one computer system having a display, a user interface and software, is described. The system uses patient image data of the treatment region to generate an image of the treatment region on the display and identifies the treatment region to ablate with a target. Tissue properties of the treatment region are identified and used to perform thermal modeling. Treatment parameters are generated and an ablation zone is calculated. A computer system display is generated showing (a) the number of ablation devices required to ablate the treatment region and the location and orientation of each ablation device in the treatment region and (b) the ablation zone.Type: GrantFiled: March 23, 2015Date of Patent: November 10, 2020Assignee: Endocare, Inc.Inventors: Alind Sahay, Robert J. Riker, Cristian Atria
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Patent number: 10182859Abstract: A cryogenic medical device for delivery of subcooled liquid cryogen to various configurations of cryoprobes is designed for the treatment of damaged, diseased, cancerous or other unwanted tissues. The device is a closed or semi-closed system in which the liquid cryogen is contained in both the supply and return stages. The device comprises a number of parts including a vacuum insulated outer dewar, submersible cryogen pump, baffled linear heat exchanger, return chamber, and a series of valves to control the flow of the liquid cryogen. The cryogenic medical device promotes the subcooling to any external cryogenic probe.Type: GrantFiled: August 26, 2009Date of Patent: January 22, 2019Assignee: Endocare, Inc.Inventors: John M. Baust, John G. Baust, Roy Cheeks, Anthony Robilotto, Kristi Snyder
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Patent number: 9974592Abstract: Cryogenic medical devices and apparatus are disclosed which are capable of generating cryogen to a supercritical state, specifically supercritical nitrogen. The cryogenic medical devices and apparatus disclosed are useful in methods of treating damaged, diseased, cancerous or other unwanted tissues.Type: GrantFiled: July 24, 2015Date of Patent: May 22, 2018Assignee: Endocare, Inc.Inventors: John M. Baust, John G. Baust, Roy E. Cheeks, Melissa K. Dobson, Anthony T. Robilotto, Kristi K. Snyder, Robert G. Van Buskirk
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Patent number: 9408654Abstract: A cryogenic medical device for delivery of subcooled liquid cryogen to various configurations of cryoprobes is designed for the treatment of damaged, diseased, cancerous or other unwanted tissues. The device is a closed or semi-closed system in which the liquid cryogen is contained in both the supply and return stages. The device is capable of generating cryogen to a supercritical state and may be utilized in any rapid cooling systems. As designed, the device comprises a number of parts including a vacuum insulated outer dewar, submersible cryogen pump, baffled linear heat exchanger, multiple pressurization cartridges, a return chamber, and a series of valves to control the flow of the liquid cryogen. The cryogenic medical device promotes the subcooling to any external cryogenic instrument.Type: GrantFiled: September 2, 2009Date of Patent: August 9, 2016Assignee: Endocare, Inc.Inventors: John M. Baust, John G. Baust, Roy Cheeks, Anthony Robilotto, Kristi Snyder
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Patent number: 9089316Abstract: A cryogenic medical device for delivery of subcooled liquid cryogen to various configurations of cryoprobes is designed for the treatment of damaged, diseased, cancerous or other unwanted tissues, particularly as utilized for the ablation of cardiac tissue in the treatment of atrial fibrillation. The device is a closed or semi-closed system in which the liquid cryogen is nitrogen contained in both the supply and return stages. The device is capable of generating cryogen to a supercritical state, specifically supercritical nitrogen, and may be utilized in any rapid cooling systems. As designed, the device also integrates endocardial catheters and epicardial probes.Type: GrantFiled: March 2, 2011Date of Patent: July 28, 2015Assignee: Endocare, Inc.Inventors: John M Baust, John G. Baust, Roy E. Cheeks, Melissa K Dobson, Anthony T. Robilotto, Kristi K. Snyder, Robert G. Van Buskirk
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Patent number: 8998888Abstract: A cryogenic medical device for delivery of subcooled liquid cryogen to various configurations of cryoprobes is designed for the treatment of damaged, diseased, cancerous or other unwanted tissues. The device is a closed or semi-closed system in which the liquid cryogen is contained in both the supply and return stages. The device is capable of generating cryogen to a supercritical state and may be utilized in any rapid cooling systems. As designed, the device comprises a number of parts including a vacuum insulated outer dewar, submersible cryogen pump, baffled linear heat exchanger, multiple pressurization cartridges, a return chamber, and a series of valves to control the flow of the liquid cryogen. The cryogenic medical device promotes the subcooling to any external cryogenic instrument.Type: GrantFiled: June 23, 2010Date of Patent: April 7, 2015Assignee: Endocare, Inc.Inventors: John M. Baust, John G. Baust, Roy Cheeks, Anthony Robilotto, Kristi Snyder
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Patent number: 8784409Abstract: A cryogenic medical device for delivery of subcooled liquid cryogen to various configurations of cryoprobes is designed for the treatment of damaged, diseased, cancerous or other unwanted tissues. The device is a closed or semi-closed system in which the liquid cryogen is contained in both the supply and return stages. The device is capable of generating cryogen to a supercritical state and may be utilized in any rapid cooling systems. As designed, the device comprises a number of parts including a vacuum insulated outer dewar, submersible cryogen pump, baffled linear heat exchanger, multiple pressurization cartridges, a return chamber, and a series of valves to control the flow of the liquid cryogen interconnected with cryotreatment devices including cryoprobes and catheters. The cryogenic medical device promotes subcooling to the tips of various external cryogenic instrument configurations.Type: GrantFiled: November 2, 2009Date of Patent: July 22, 2014Assignee: Endocare, Inc.Inventors: Anthony Robilotto, Kristi K. Snyder, John G Baust, John M. Buast, Roy E. Cheeks
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Patent number: 8747396Abstract: A cryosurgical probe assembly that includes a gas delivery assembly, including a stem and a fluid conduit subassembly bonded to the stem. The fluid conduit subassembly delivers and returns cooling fluid used for cryogenic cooling. The fluid conduit subassembly, comprises a shaft for providing a heat exchange surface for cryogenic ablation; a housing securely connected to said shaft; and, an insulation element slideably engaged with an inner surface of the shaft and slideably engaged with the stem. The cryosurgical probe assembly includes an adjustable sliding apparatus that includes a slider assembly securely attached to said insulation tube for slideably guiding the insulation tube along said shaft; and, a button assembly operatively connected to the slider assembly for allowing a user to actuate the slider assembly to provide a desired adjustment of the insulation tube relative to the shaft. A handle assembly is positioned about the housing.Type: GrantFiled: October 18, 2009Date of Patent: June 10, 2014Assignee: Endocare, Inc.Inventors: Thach Duong, Jay J. Eum
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Patent number: 8740891Abstract: A flexible multi-tubular cryoprobe, including a housing for receiving an inlet flow of near critical cryogenic fluid from a fluid source and for discharging an outlet flow of the cryogenic fluid. A plurality of fluid transfer tubes are securely attached to the housing. This includes a set of inlet fluid transfer tubes for receiving the inlet flow from the housing; and, a set of outlet fluid transfer tubes for discharging the outlet flow to the housing. Each of the fluid transfer tubes is formed of material that maintains flexibility in a full range of temperatures from ?200° C. to ambient temperature. Each fluid transfer tube has an inside diameter in a range of between about 0.10 mm and 1.0 mm and a wall thickness in a range of between about 0.01 mm and 0.30 mm. An end cap is positioned at the ends of the plurality of fluid transfer tubes to provide fluid transfer from the inlet fluid transfer tubes to the outlet fluid transfer tubes.Type: GrantFiled: November 19, 2008Date of Patent: June 3, 2014Assignee: Endocare, Inc.Inventors: Alexei V. Babkin, Peter J. Littrup, Robert V. Duncan, William J. Nydam
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Patent number: 8740892Abstract: An expandable, flexible multi-tubular cryoprobe operational with a near critical cryogenic working fluid. The inlet fluid transfer micro-tubes utilized are formed of material that maintains flexibility in a full range of temperatures from ?200° C. to ambient temperature. During operation, the cryoprobe is mechanically actuated to provide radial expansion of the inlet fluid transfer micro-tubes. Thus, enhanced thermal contact with target biological tissue to be treated is provided.Type: GrantFiled: November 19, 2008Date of Patent: June 3, 2014Assignee: Endocare, Inc.Inventors: Alexei V. Babkin, Anatoly I. Efremov, Jay J. Eum
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Patent number: 8671700Abstract: The cryogenic fluid generator includes at least one pump assembly having an actuator mounted to a container assembly. A pump assembly housing includes a longitudinal positioning opening and a pressurization cavity at a distal end terminating with a pump assembly outlet. An internal check valve assembly includes a shaft positioned within an opening of the pump assembly housing that extends into the pressurization cavity. The shaft is attached to the actuator and includes a longitudinal guidance slot; a fluid passageway; and, an internal sealing surface. A positioning bar assembly is positioned within the guidance slot. A connecting rod is securely connected at a first end to the positioning bar assembly, the connecting rod being positioned within the fluid passageway and terminating with a flow inhibiting element. A seal is positioned between the pump assembly housing and the check valve to provide a closure for the pressurization cavity.Type: GrantFiled: January 20, 2010Date of Patent: March 18, 2014Assignee: Endocare, Inc.Inventors: Thach Duong, Jay J. Eum
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Patent number: 8562593Abstract: A cryosurgical system for assisting an operator in placing and operating cryosurgical probes in the prostate of a human patient. The cryosurgical system includes a computer system being programmed with software capable of performing the following steps: a) capturing a plurality of transverse views of the prostate; b) capturing a sagittal view of the prostate; c) outlining the capsule of the prostate, the urethra and the rectal wall of the patient with the assistance of the operator, utilizing the captured plurality of transverse views and the captured sagittal view; d) constructing a 3-dimensional model of the prostate, the urethra and the rectal wall utilizing the outlines of step c), above; and, e) utilizing the 3-dimensional model of the prostate, the urethra and the rectal wall to determine i) the number of cryosurgical probes to be utilized; ii) probe settings; and, iii) probe placement positions. The resultant ice thus produced by the cryosurgical probes is optimized for a specific patient.Type: GrantFiled: May 25, 2012Date of Patent: October 22, 2013Assignee: Endocare, Inc.Inventors: Shenghao Bao, Jay J. Eum
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Patent number: 8551081Abstract: A cryosurgical system and method for supplying cryogen to a probe. The system including a container filled with cryogen and having bellows of a pump submerged within said cryogen. Conduits fluidly interconnect the bellows and a probe that is outside the container to permit the cryogen to be forced from the bellows to the probe upon activation of pump. A pressure relief valve is fluidly coupled to the conduits and positioned between the bellows and the probe. After initially forcing cryogen to the probe at a pressure that establishes a colligative-based sub-cooling of the liquid cryogen, the pressure relief valve is activated to lower the pressure of the cryogen to a running pressure.Type: GrantFiled: October 3, 2010Date of Patent: October 8, 2013Assignee: Endocare, Inc.Inventors: John G. Baust, Roy Cheeks
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Patent number: 8439905Abstract: The device of the invention takes the form of a catheter/probe and is a closed loop system in which cryogen is delivered along the length of the catheter/probe to the tip where freezing occurs, and then recirculated. The device is a tube within a tube and comprises a number of parts including supply and return (internal) tubes, outer sheath (external tube) seaJed to the inner tubes at one or both ends with a gas filled lumen between the internal and external tubes. The lumen of the external tube is filled with a saturated gas which solidifies upon cooling, thereby creating a vacuum along the catheter length and providing for insulation between the inner and outer tubes, and preventing freezing along the probe shaft length. The outside surface of the internal tubes is modified to potentiate gas nucleation on the outer surfaces of the internal tubes when cooled.Type: GrantFiled: September 18, 2009Date of Patent: May 14, 2013Assignee: Endocare, Inc.Inventors: John M. Baust, John G. Baust, Roy Cheeks, Anthony Robilotto, Kristi Snyder
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Patent number: 8187260Abstract: A cryosurgical system for assisting an operator in placing and operating cryosurgical probes in the prostate of a human patient. The cryosurgical system includes a computer system being programmed with software capable of performing the following steps: a) capturing a plurality of transverse views of the prostate; b) capturing a sagittal view of the prostate; c) outlining the capsule of the prostate, the urethra and the rectal wall of the patient with the assistance of the operator, utilizing the captured plurality of transverse views and the captured sagittal view; d) constructing a 3-dimensional model of the prostate, the urethra and the rectal wall utilizing the outlines of step c), above; and, e) utilizing the 3-dimensional model of the prostate, the urethra and the rectal wall to determine i) the number of cryosurgical probes to be utilized; ii) probe settings; and, iii) probe placement positions. The resultant ice thus produced by the cryosurgical probes is optimized for a specific patient.Type: GrantFiled: December 29, 2006Date of Patent: May 29, 2012Assignee: Endocare, Inc.Inventors: Shenghao Bao, Jay J. Eum
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Patent number: 8029502Abstract: The cryosurgical probe assembly with multiple deployable cryoprobes includes a) a housing assembly; b) a plurality of elongated structural support elements, each securely connected at a first end to the housing assembly; c) a tip member securely connected to second ends of the plurality of elongated structural support elements, the tip member including a plurality of cryoprobe openings; and, d) a plurality of cryoprobes each having a shaft thereon, each shaft being deployable through a respective cryoprobe opening during operation to a deployed position used for ablating tissue. In an alternate embodiment, a cylindrical housing is utilized rather than elongated structural support elements.Type: GrantFiled: May 9, 2006Date of Patent: October 4, 2011Assignee: Endocare, Inc.Inventor: Thach Duong
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Patent number: D690808Type: GrantFiled: June 13, 2012Date of Patent: October 1, 2013Assignee: Endocare, Inc.Inventor: Janarthanan Laxmanan