Abstract: Disclosed herein are device assemblies for endovascular prosthesis implantation in a human patient comprising a collapsed delivery configuration and an expanded deployed configuration comprising: a stent frame comprising a plurality of expandable stent cells arranged in more than one layer and stacked in a longitudinal direction; a valve attached to the stent frame; and an expandable sealing skirt coupled to the stent frame, the expandable sealing skirt comprising a protruding region configured to expand radially past the stent frame when the device assembly is in the expanded deployed configuration and a non-protruding region.

Abstract: Expandable sealing means for endoluminal devices have been developed for controlled activation. The devices have the benefits of a low profile mechanism (for both self-expanding and balloon-expanding prostheses), contained, not open, release of the material, active conformation to the “leak sites” such that leakage areas are filled without disrupting the physical and functional integrity of the prosthesis, and on-demand, controlled activation, that may not be pressure activated.