Patents Assigned to Endoluminal Therapeutics, Inc.
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Patent number: 6802811Abstract: Implants and implants, including sensors responsive to pressure, fluid flow, concentration of analytes, pH and other variables, including a feedback loop and means for modifying the implant after placement in a patient in response to measurements made using the sensors, have been developed. These are particularly useful in cardiology, where the implants contain one or more sensors responsive to variables which change over time, for example, pressure which is indicative of changes in fluid flow and diameter of the vessel in which the implant has been placed. Feedback from the sensor(s) either directly, or indirectly via monitoring means external to the patient, signal changes that may be required, such as expansion of the implant in the case where the vessel diameter changes over time or the implant becomes unstable or migrates.Type: GrantFiled: September 15, 2000Date of Patent: October 12, 2004Assignee: Endoluminal Therapeutics, Inc.Inventor: Marvin J. Slepian
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Patent number: 6699272Abstract: A novel process for paving or sealing the interior surface of a tissue lumen by entering the interior of the tissue lumen and applying a polymer to the interior surface of the tissue lumen. This is accomplished using a catheter which delivers the polymer to the tissue lumen and causes it to conform to the interior surface of the lumen. The polymer can be delivered to the lumen as a monomer or prepolymer solution, or as an at least partially preformed layer on an expansile member.Type: GrantFiled: December 13, 2001Date of Patent: March 2, 2004Assignee: Endoluminal Therapeutics, Inc.Inventors: Marvin J. Slepian, Anton Schindler
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Publication number: 20040024419Abstract: A novel process for paving or sealing the interior surface of a tissue lumen by entering the interior of the tissue lumen and applying a polymer to the interior surface of the tissue lumen. This is accomplished using a catheter which delivers the polymer to the tissue lumen and causes it to conform to the interior surface of the lumen. The polymer can be delivered to the lumen as a monomer or prepolymer solution, or as an at least partially preformed layer on an expansile member.Type: ApplicationFiled: July 31, 2003Publication date: February 5, 2004Applicant: Endoluminal Therapeutics, Inc.Inventors: Marvin J. Slepian, Anton Schindler
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Publication number: 20020176849Abstract: Methods, devices and materials for the treatment or repair, replacement, transplantation or augmentation of tissues in endomural zones specifically by open surgical, minimally invasive or percutaneous transmural or trans parenchymal application of polymeric material alone or in combination with bioactive agents or cells, have been developed. These methods and systems are useful to repair, alter function, replace function or augment function of the central or endomural aspects of solid organs or tubular body structures.Type: ApplicationFiled: February 8, 2002Publication date: November 28, 2002Applicant: Endoluminal Therapeutics, Inc.Inventor: Marvin J. Slepian
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Patent number: 6443941Abstract: A novel process for paving or sealing the interior surface of a tissue lumen by entering the interior of the tissue lumen and applying a polymer to the interior surface of the tissue lumen. This is accomplished using a catheter which delivers the polymer to the tissue lumen and causes it to conform to the interior surface of lumen. The polymer can be delivered to the lumen as a monomer or prepolymer solution, or as an at least partially preformed layer on an expansible member.Type: GrantFiled: July 24, 2000Date of Patent: September 3, 2002Assignee: Endoluminal Therapeutics, Inc.Inventors: Marvin J. Slepian, Anton Schindler
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Patent number: 6290729Abstract: A method for providing a synthetic barrier made of biocompatible polymeric materials in vivo which involves application of a material to a tissue or cellular surface such as the interior surface of a blood vessel, tissue lumen or other hollow space, is disclosed herein. The material may also be applied to tissue contacting surfaces of implantable medical devices. The polymeric materials are characterized by a fluent state which allows application to and, preferably adhesion to, tissue lumen surfaces, which can be increased or altered to a second less fluent state in situ; controlled permeability and degradability; and, in the preferred embodiments, incorporation of bioactive materials for release in vivo, either to the tissue lumen surface or to the interior of the lumen, which alter cell to cell interactions.Type: GrantFiled: December 3, 1997Date of Patent: September 18, 2001Assignee: Endoluminal Therapeutics, Inc.Inventors: Marvin J. Slepian, Stephen P. Massia
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Method and apparatus for treatment of focal disease in hollow tubular organs and other tissue lumens
Patent number: 6287320Abstract: The present invention provides a technique for treating diseased portions of tissue lumens by the focal introduction of at least one therapeutic agent at the diseased region. A catheter is positioned in a lumen such that first and second expansile members surround the diseased portion of tissue. The expansile members are expanded to occlude the diseased region and a therapeutic agent is introduced to the occluded diseased region via the catheter. The catheter is allowed to remain in place for a therapeutically effective period of time to allow the therapeutic agent to contact the diseased portion for such a period of time. The catheter arrangement also can be used to occlude a diseased region, remove physiological fluid from the occluded region and subsequently to disrupt the diseased region and/or apply the therapeutic agent. The therapeutic agent can be selected to suppress cell proliferation in the diseased region, and the occluded region can be treated with a medicament to promote vessel healing.Type: GrantFiled: August 26, 1997Date of Patent: September 11, 2001Assignee: Endoluminal Therapeutics, Inc.Inventor: Marvin J. Slepian -
Patent number: 6071956Abstract: An exogenous stimulus is applied to tissues or cells which are at risk in a subsequent surgical procedure or other intervention which induces a response by the cells that minimizes reaction to the subsequent procedure. Stimuli can be chemical, physiological or physical. Examples include those stimuli known to induce expression of stress response proteins or heat shock proteins, especially heat shock protein 70 (hsp 70) and hsp 90, for example, exposure to heat or dilute hydrogen peroxide, or direct administration of exogenous heat shock proteins, or those stimuli which act to inhibit or reduce heat shock protein expression, for example, treatment with flavonoids.Type: GrantFiled: September 23, 1998Date of Patent: June 6, 2000Assignee: Endoluminal Therapeutics, Inc.Inventors: Marvin J. Slepian, Stephen P. Massia
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Patent number: 5947977Abstract: A novel process for paving or sealing the interior surface of a tissue lumen by entering the interior of the tissue lumen and applying a polymer to the interior surface of the tissue lumen. This is accomplished using a catheter which delivers the polymer to the tissue lumen and causes it to conform to the interior surface of lumen. The polymer can be delivered to the lumen as a monomer or prepolymer solution, or as an at least partially preformed layer on an expansile member.Type: GrantFiled: June 7, 1995Date of Patent: September 7, 1999Assignee: Endoluminal Therapeutics, Inc.Inventors: Marvin J. Slepian, Anton Schindler
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Patent number: 5914345Abstract: An exogenous stimulus is applied to tissues or cells which are at risk in a subsequent surgical procedure or other intervention which induces a response by the cells that minimizes reaction to the subsequent procedure. Stimuli can be chemical, physiological or physical. Examples include those stimuli known to induce expression of stress response proteins or heat shock proteins, especially heat shock protein 70 (hsp 70) and hsp 90, for example, exposure to heat or dilute hydrogen peroxide, or direct administration of exogenous heat shock proteins, or those stimuli which act to inhibit or reduce heat shock protein expression, for example, treatment with flavonoids.Type: GrantFiled: October 11, 1994Date of Patent: June 22, 1999Assignee: Endoluminal Therapeutics, Inc.Inventors: Marvin J. Slepian, Stephen P. Massia
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Patent number: 5843156Abstract: A method for providing a synthetic barrier made of biocompatible polymeric materials in vivo which involves application of a material to a tissue or cellular surface such as the interior surface of a blood vessel, tissue lumen or other hollow space, is disclosed herein. The material may also be applied to tissue contacting surfaces of implantable medical devices. The polymeric materials are characterized by a fluent state which allows application to and, preferably adhesion to, tissue lumen surfaces, which can be increased or altered to a second less fluent state in situ; controlled permeability and degradability; and, in the preferred embodiments, incorporation of bioactive materials for release in vivo, either to the tissue lumen surface or to the interior of the lumen, which alter cell to cell interactions.Type: GrantFiled: May 6, 1994Date of Patent: December 1, 1998Assignee: Endoluminal Therapeutics, Inc.Inventors: Marvin Slepian, Stephen P. Massia
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Patent number: 5800538Abstract: A novel process for paving or sealing the interior surface of a tissue lumen by entering the interior of the tissue lumen and applying a polymer to the interior surface of the tissue lumen. This is accomplished using a catheter which delivers the polymer to the tissue lumen and causes it to conform to the interior surface of lumen. The polymer can be delivered to the lumen as a monomer or prepolymer solution, or as an at least partially preformed layer on an expansile member.Type: GrantFiled: June 7, 1995Date of Patent: September 1, 1998Assignee: Endoluminal Therapeutics, Inc.Inventors: Marvin J. Slepian, Anton Schindler
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Patent number: 5749922Abstract: A novel process for paving or sealing the interior surface of a tissue lumen by entering the interior of the tissue lumen and applying a polymer to the interior surface of the tissue lumen. This is accomplished using a catheter which delivers the polymer to the tissue lumen and causes it to conform to the interior surface of lumen. The polymer can be delivered to the lumen as a monomer or prepolymer solution, or as an at least partially preformed layer on an expansile member.Type: GrantFiled: June 7, 1995Date of Patent: May 12, 1998Assignee: Endoluminal Therapeutics, Inc.Inventors: Marvin J. Slepian, Anton Schindler
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Biodegradable polymeric endoluminal sealing process, apparatus and polymeric product for use therein
Patent number: 5674287Abstract: A process for paving or sealing the interior surface of a tissue lumen by entering the interior tissue lument and applying a polymer to the interior surface of the tissue lumen. This is accomplished using a catheter which delivers the polymer to the tissue lument and causes it to conform to the interior surface of the lumen. The polymer can be delivered to the lumen as a monomer or prepolymer solution, or as an at least partially preformed layer on an expansible member.Type: GrantFiled: January 14, 1994Date of Patent: October 7, 1997Assignee: Endoluminal Therapeutics, Inc.Inventors: Marvin J. Slepian, Anton Schindler -
Method and apparatus for treatment of focal disease in hollow tubular organs and other tissue lumens
Patent number: 5662609Abstract: The present invention provides a technique for treating diseased portions of tissue lumens by the focal introduction of at least one therapeutic agent at the diseased region. A catheter is positioned in a lumen such that first and second expansile members surround the diseased portion of tissue. The expansile members are expanded to occlude the diseased region and a therapeutic agent is introduced to the occluded diseased region via the catheter. The catheter is allowed to remain in place for a therapeutically effective period of time to allow the therapeutic agent to contact the diseased portion for such a period of time. The catheter arrangement also can be used to occlude a diseased region, remove physiological fluid from the occluded region and subsequently to disrupt the diseased region and/or apply the therapeutic agent. The therapeutic agent can be selected to suppress cell proliferation in the diseased region, and the occluded region can be treated with a medicament to promote vessel healing.Type: GrantFiled: April 13, 1994Date of Patent: September 2, 1997Assignee: Endoluminal Therapeutics, Inc.Inventor: Marvin J. Slepian -
Patent number: 5575815Abstract: A method for providing a synthetic barrier made of biocompatible polymeric materials in vivo which involves application of a material to a tissue or cellular surface such as the interior surface of a blood vessel, tissue lumen or other hollow space, is disclosed herein. The material may also be applied to tissue contacting surfaces of implantable medical devices. The polymeric materials are characterized by a fluent state which allows application to and, preferably adhesion to, tissue lumen surfaces, which can be increased or altered to a second less fluent state in situ; controlled permeability and degradability; and, in some embodiments, incorporation of bioactive materials for release in vivo, either to the tissue lumen surface or to the interior of the lumen.Type: GrantFiled: October 6, 1993Date of Patent: November 19, 1996Assignee: Endoluminal Therapeutics, Inc.Inventors: Marvin Slepian, Stephen P. Massia
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Method and apparatus for treatment of focal disease in hollow tubular organs and other tissue lumens
Patent number: 5328471Abstract: Diseased portions of tissue lumens can be advantageously treated by the focal introduction of at least one therapeutic agent to the lumen at the diseased point. This can be accomplished by(a) introducing a catheter into the tissue lumen, said catheter comprising first and second expansile members and means for supplying therapeutic agent into a space between said first and second expansile members, and said catheter being positioned such that said first and second expansile members are disposed on opposite sides of the diseased region;(b) expanding the expansile members to occlude the diseased region of the tissue lumen;(c) introducing therapeutic agent to the occluded diseased region via said means for supplying therapeutic agent;(d) allowing the catheter to remain in place for a therapeutically effective period of time;(e) contracting the expansile members; and(f) removing the catheter.Type: GrantFiled: August 4, 1993Date of Patent: July 12, 1994Assignee: Endoluminal Therapeutics, Inc.Inventor: Marvin J. Slepian -
Patent number: 5213580Abstract: A novel process for paving or stabilizing sealing the interior surface of a body vessel or organ by entering the interior of the vessel or organ and applying a polymer to the interior surface of the vessel or organ.Type: GrantFiled: March 25, 1992Date of Patent: May 25, 1993Assignee: Endoluminal Therapeutics, Inc.Inventors: Marvin J. Slepian, Anton Schindler