Patents Assigned to EndoValve, Inc.
  • Patent number: 8070802
    Abstract: Valve prostheses are disclosed that are adapted for secure and aligned placement relative to a heart annulus. The valve prostheses may be placed in a non-invasive manner, e.g., via transcatheter techniques. The valve prosthesis may include a resilient ring, a plurality of leaflet membranes mounted with respect to the resilient ring, and a plurality of positioning elements movably mounted with respect to the flexible ring. Each of the positioning elements defines respective proximal, intermediate, and distal tissue engaging regions cooperatively configured and dimensioned to simultaneously engage separate corresponding areas of the tissue of an anatomical structure, including respective first, second, and third elongate tissue-piercing elements.
    Type: Grant
    Filed: February 8, 2008
    Date of Patent: December 6, 2011
    Assignees: The Trustees of the University of Pennsylvania, EndoValve, Inc.
    Inventors: David G. Lamphere, Tuan Anh Nguyen, Howard C. Herrmann, Todd C. Tomba, Robert C. Gorman, Joseph H. Gorman, III
  • Patent number: 7753949
    Abstract: Valve prostheses are disclosed that are adapted for secure and aligned placement relative to a heart annulus. The valve prostheses may be placed in a non-invasive manner, e.g., via trans-catheter techniques, and may be positioned/repositioned until proper alignment and positioning is achieved. The valve prosthesis may include a resilient ring, a plurality of leaflet membranes mounted with respect to the resilient ring, and a plurality of positioning elements movably mounted with respect to the flexible ring, each of the positioning elements defining a first tissue engaging region and a second tissue engaging region spaced from the first tissue engaging region.
    Type: Grant
    Filed: October 10, 2007
    Date of Patent: July 13, 2010
    Assignees: The Trustees of the University of Pennsylvania, EndoValve, Inc.
    Inventors: David G. Lamphere, Tuan Anh Nguyen, Howard C. Herrmann
  • Publication number: 20100174363
    Abstract: Valve prostheses are disclosed that are adapted for secure and aligned placement relative to a heart annulus. The valve prostheses may be placed in a non-invasive manner, e.g., via trans-catheter techniques. The valve prosthesis may include a support ring, a plurality of leaflet membranes mounted with respect to the support ring, and a plurality of retention clip elements. The support structure is advantageously formed from a tubular member or flat stock of shape memory metal. A delivery system for delivery of a valve prosthesis embodying the disclosed support structure is also disclosed.
    Type: Application
    Filed: December 30, 2009
    Publication date: July 8, 2010
    Applicant: EndoValve, Inc.
    Inventor: Salvatore Castro
  • Publication number: 20080221672
    Abstract: Valve prostheses are disclosed that are adapted for secure and aligned placement relative to a heart annulus. The valve prostheses may be placed in a non-invasive manner, e.g., via trans-catheter techniques. The valve prosthesis may include a resilient ring, a plurality of leaflet membranes mounted with respect to the resilient ring, and a plurality of positioning elements movably mounted with respect to the flexible ring. Each of the positioning elements defines respective proximal, intermediate, and distal tissue engaging regions cooperatively configured and dimensioned to simultaneously engage separate corresponding areas of the tissue of an anatomical structure, including respective first, second, and third elongate tissue-piercing elements.
    Type: Application
    Filed: February 8, 2008
    Publication date: September 11, 2008
    Applicants: ENDOVALVE, INC., THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: David G. Lamphere, Tuan Anh Nguyen, Howard C. Herrmann, Todd C. Tomba, Robert C. Gorman, Joseph H. Gorman
  • Publication number: 20080208328
    Abstract: Valve prosthesis systems and methods/systems for placement of such valve prostheses are provided that facilitate efficient, reliable and minimally invasive delivery modalities. The placement systems and methods permit remote manipulation and positioning of the valve prosthesis such that desirable placement relative to anatomical structures, e.g., the heart annulus, may be achieved. The valve prosthesis includes a resilient ring, a plurality of leaflet membranes mounted with respect to the resilient ring, and a plurality of positioning elements movably mounted with respect to the flexible ring. The delivery system includes a first elongate element that terminates at the valve prosthesis and is manipulable by an operator to remotely rotate the positioning elements relative to the flexible ring. A second elongate element terminates at the valve prosthesis and is manipulable by an operator to remotely advance the valve prosthesis downward into an anatomical annulus.
    Type: Application
    Filed: October 10, 2007
    Publication date: August 28, 2008
    Applicants: ENDOVALVE, INC., THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Joseph D. Antocci, David G. Lamphere, Salvatore Castro, Gregorio Ramon M. Abesames, Howard C. Herrmann
  • Publication number: 20080208332
    Abstract: Valve prostheses are disclosed that are adapted for secure and aligned placement relative to a heart annulus. The valve prostheses may be placed in a non-invasive manner, e.g., via trans-catheter techniques, and may be positioned/repositioned until proper alignment and positioning is achieved. The valve prosthesis may include a resilient ring, a plurality of leaflet membranes mounted with respect to the resilient ring, and a plurality of positioning elements movably mounted with respect to the flexible ring, each of the positioning elements defining a first tissue engaging region and a second tissue engaging region spaced from the first tissue engaging region.
    Type: Application
    Filed: October 10, 2007
    Publication date: August 28, 2008
    Applicants: ENDOVALVE, INC., THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: David G. Lamphere, Tuan Anh Nguyen, Howard C. Herrmann