Abstract: The present invention discloses a device and method for measuring a horizontal/vertical permeability of a hydrate reservoir. The device includes a cooling water/saturated methane water tank, a water injection pump, a methane gas tank, a booster pump, an air compressor, a high-pressure gas tank, a back pressure valve, a gas tank, a data acquisition instrument, a constant-temperature water bath and a hydrate reservoir horizontal/vertical permeability measuring apparatus provided in the constant-temperature water bath, where the cooling water/saturated methane water tank is provided with a water circulation inlet and an intake line at an upper part and a water circulation outlet at the bottom; the intake line is provided thereon with an intake control gate valve; the bottom of the cooling water/saturated methane water tank is in communication with the water injection pump.