Abstract: A composition comprising intact minicells that contain a drug molecule is useful for targeted drug delivery. One targeted drug delivery method employs bispecific ligands, comprising a first arm that carries specificity for a bacterially derived minicell surface structure and a second arm that carries specificity for a mammalian cell surface receptor, to target drug-loaded minicells to specific mammalian cells and to cause endocytosis of the minicells by the mammalian cells. Another drug delivery method exploits the natural ability of phagocytic mammalian cells to engulf minicells without the use of bispecific ligands.
Type:
Application
Filed:
April 9, 2014
Publication date:
August 7, 2014
Applicant:
EnGeneIC Gene Therapy Pty Limited
Inventors:
Himanshu Brahmbhatt, Jennifer MACDIARMID
Abstract: A composition comprising intact minicells that contain a drug molecule is useful for targeted drug delivery. One targeted drug delivery method employs bispecific ligands, comprising a first arm that carries specificity for a bacterially derived minicell surface structure and a second arm that carries specificity for a mammalian cell surface receptor, to target drug-loaded minicells to specific mammalian cells and to cause endocytosis of the minicells by the mammalian cells. Another drug delivery method exploits the natural ability of phagocytic mammalian cells to engulf minicells without the use of bispecific ligands.
Type:
Application
Filed:
January 27, 2005
Publication date:
February 28, 2008
Applicant:
EnGeneIC Gene Therapy Pty Limited
Inventors:
Himanshu Brahmbhatt, Jennifer MacDiarmid