Abstract: Disclosed are methods for reliably detecting the presence of proteins, including proteins with various post-translational modifications (phosphorylation, glycosylation, methylation, acetylation, etc.) in a sample by the use of one or more capture agents that recognize and interact with recognition sequences uniquely characteristic of a protein or a set of proteins (Proteome Epitope Tags, or PETs) in the sample. Arrays comprising these capture agents or PETs are also provided.
Abstract: Disclosed are methods for reliably detecting the presence of proteins, especially proteins with various post-translational modifications (phosphorylation, glycosylation, methylation, acetylation, etc.) in a sample by the use of one or more capture agents that recognize and interact with recognition sequences uniquely characteristic of a set of proteins (Proteome Epitope Tags, or PETs) in the sample. Arrays comprising these capture agents or PETs are also provided.
Type:
Application
Filed:
November 13, 2003
Publication date:
September 16, 2004
Applicant:
engeneOS, Inc.
Inventors:
Frank D. Lee, Xun Meng, David Livingston
Abstract: Disclosed are methods for reliably detecting the presence of proteins in a sample by the use of capture agents that recognize and interact with recognition sequences uniquely characteristic of a set of proteins in the sample. Arrays comprising these capture agents are also provided.
Type:
Application
Filed:
May 12, 2003
Publication date:
February 26, 2004
Applicant:
engeneOS, Inc.
Inventors:
Frank D. Lee, Xun Meng, John W. Chan, Shengsheng Zhang, Stephen J. Benkovic
Abstract: The present invention provides Modular Molecular Clasps and methods of using these Modular Molecular Clasps in a wide range of applications in the health care industry, e.g., in therapy, in clinical diagnostics, in in vivo imaging or in drug discovery. The Modular Molecular Clasps of the present invention also have industrial and environmental applications, e.g., in environmental diagnostics, industrial diagnostics, food safety, toxicology, catalysis of reactions or high-throughput screening; as well as applications in the agricultural industry and in basic research. Methods of designing the Modular Molecular Clasps, as well as arrays and biosensors comprising these Modular Molecular Clasps are also provided.
Type:
Application
Filed:
November 28, 2001
Publication date:
December 19, 2002
Applicant:
engeneOS, Inc.
Inventors:
Carlo Dante Rizzuto, Noubar Boghos Afeyan, Frank Don Lee, George McDonald Church, Ruchira Das Gupta, John Jacob Schwartz, Bin Zhang, Alexey Alexandrovich Lugovskoy