Patents Assigned to Engineered Antigens Inc.
  • SLAM polynucleotides and polypeptides and uses thereof
    Patent number: 12296000
    Abstract: Novel methods for exporting target proteins from the cytosol to the extracellular surface of bacterial cells are provided. The methods are useful in that they permit the preparation of vaccines for the prevention of bacterial infectious diseases.
    Type: Grant
    Filed: December 19, 2023
    Date of Patent: May 13, 2025
    Assignee: Engineered Antigens Inc.
    Inventors: Trevor F. Moraes, Christine Chieh-Lin Lai, Yogesh Hooda, Andrew Judd, Anthony B. Schryvers, Scott D. Gray-Owen
  • SLAM polynucleotides and polypeptides and uses thereof
    Patent number: 11872275
    Abstract: Novel methods for exporting target proteins from the cytosol to the extracellular surface of bacterial cells are provided. The methods are useful in that they permit the preparation of vaccines for the prevention of bacterial infectious diseases.
    Type: Grant
    Filed: August 18, 2021
    Date of Patent: January 16, 2024
    Assignee: ENGINEERED ANTIGENS INC.
    Inventors: Trevor F. Moraes, Christine Chieh-Lin Lai, Yogesh Hooda, Andrew Judd, Anthony B. Schryvers, Scott D. Gray-Owen
  • SLAM polynucleotides and polypeptides and uses thereof
    Patent number: 11123418
    Abstract: The present disclosure relates to methods for exporting target proteins (e.g., surface lipoproteins) from the cytosol to the extracellular surface of bacterial cells using surface lipoprotein assembly modulator (SLAM) polypeptides. The use of SLAM polypeptides in a method of preparing vaccines useful in the prevention of bacterial infectious diseases is also taught.
    Type: Grant
    Filed: February 10, 2017
    Date of Patent: September 21, 2021
    Assignee: Engineered Antigens Inc.
    Inventors: Trevor F. Moraes, Christine Chieh-Lin Lai, Yogesh Hooda, Andrew Judd, Anthony B. Schryvers, Scott D. Gray-Owen
  • Immunogenic compositions and vaccines derived from bacterial surface receptor proteins
    Patent number: 10149900
    Abstract: The disclosure provides immunogenic compositions comprising a polypeptide comprising a C-lobe domain or an N-lobe domain of a HIBP surface receptor protein obtainable from or obtained from a Gram-negative bacterial species. The HIBP surface receptor proteins have been modified in such a manner that they are unable to bind host iron binding protein. Methods of making and using these immunogenic positions to prepare animal and human vaccines are also provided.
    Type: Grant
    Filed: December 1, 2014
    Date of Patent: December 11, 2018
    Assignee: Engineered Antigens Inc.
    Inventors: Anthony B. Schryvers, Trevor F. Moraes, Scott Gray-Owen