Abstract: The invention provides methods and devices for preparing frozen vitrified samples for transmission electron microscopy. By reducing the volume of sample from microliter scale to picoliter scale, the requirement for blotting of excess fluid is minimized or eliminated.
Type:
Grant
Filed:
July 11, 2017
Date of Patent:
March 26, 2019
Assignees:
The Scripps Research Institute, Engineering Arts LLC
Inventors:
Bridget Carragher, Clinton S. Potter, Tilak Jain, Peter Kahn, Peter Wiktor