Abstract: Embodiments of an apparatus are disclosed, the apparatus comprising: a substrate having a first end and an opposite, second end; a plurality of sensors proximate to the first end of the substrate, each sensor including: a first electrode; a second electrode at least partially surrounding the first electrode; and an active sensing element over the first electrode, a surface of the active sensing element being functionalized detect analytes in a sample derived from an environmental source; a plurality of contact pads proximate to the second end of the substrate, each contact pad being conductively coupled to the first electrode or the second electrode of a corresponding sensor in the plurality of sensors; and a cartridge surrounding the plurality of sensors and providing an enclosed space to contain the sample over the plurality of sensors.

Abstract: A biosensor device includes a porous substrate, where the substrate comprises semiconductor elements functionalized to conjugate with a particular analyte, the semiconductor elements are embedded within at least a portion of the substrate, and the substrate is to absorb fluid capable of carrying the particular analyte. The device further includes two or more electrodes attached to the substrate to correspond to the portion of the substrate, where the portion of the substrate further comprises Room-Temperature Ionic Liquid (RTIL).

Abstract: Disclosed herein are devices, apparatus, systems, methods and kits for performing immunoassay tests on a sample. The A sensing apparatus is provided for detecting a plurality of different target analytes in a sample. The apparatus may comprise an array of sensing devices provided on a substrate, each sensing device in the array comprising a working electrode having (1) semiconducting nanostructures disposed thereon and (2) a capture reagent coupled to the semiconducting nanostructures that selectively binds to a different target analyte in the sample. The apparatus may also comprise sensing circuitry that (1) simultaneously detects changes to electron and ion mobility and charge accumulation in the array of sensing devices when the capture reagents in the array of sensing devices selectively bind to the plurality of different target analytes, and (2) determines the presence and concentrations of the plurality of different target analytes in the sample based on the detected changes.

Abstract: Disclosed herein are devices, apparatus, systems, methods and kits for performing immunoassay tests on a sample. The A sensing apparatus is provided for detecting a plurality of different target analytes in a sample. The apparatus may comprise an array of sensing devices provided on a substrate, each sensing device in the array comprising a working electrode having (1) semiconducting nanostructures disposed thereon and (2) a capture reagent coupled to the semiconducting nanostructures that selectively binds to a different target analyte in the sample. The apparatus may also comprise sensing circuitry that (1) simultaneously detects changes to electron and ion mobility and charge accumulation in the array of sensing devices when the capture reagents in the array of sensing devices selectively bind to the plurality of different target analytes, and (2) determines the presence and concentrations of the plurality of different target analytes in the sample based on the detected changes.

Abstract: A sensor device includes a porous substrate layer and an array of sensors to accept a sample. The array of sensors includes a plurality of sensors, each of the plurality of sensors includes respective semiconducting nanostructures with a respective capture reagent coupled to the semiconducting nanostructures that selectively binds to a respective target analyte in the sample. The array of sensors includes a first subset of sensors with first capture reagents to bind to biomarkers characteristic of a particular disease and a second subset of sensors with second capture reagents to bind to one of cytokines, chemokines, enzymes, metabolites, or antibodies present in the sample.

Abstract: Systems, methods, and devices include a high-density analog multiplexer topology. Such topologies can be used, for example, in sensor device applications. An analog multiplexer circuit can include circuitry to receive N input signals; and circuitry to generate N selection signals for selecting one of said N data signals to be output from said analog multiplexer circuit. The analog multiplexer comprises one or more analog impedances.

Abstract: Disclosed herein are devices, apparatus, systems, methods and kits for performing immunoassay tests on a sample. The A sensing apparatus is provided for detecting a plurality of different target analytes in a sample. The apparatus may comprise an array of sensing devices provided on a substrate, each sensing device in the array comprising a working electrode having (1) semiconducting nanostructures disposed thereon and (2) a capture reagent coupled to the semiconducting nanostructures that selectively binds to a different target analyte in the sample. The apparatus may also comprise sensing circuitry that (1) simultaneously detects changes to electron and ion mobility and charge accumulation in the array of sensing devices when the capture reagents in the array of sensing devices selectively bind to the plurality of different target analytes, and (2) determines the presence and concentrations of the plurality of different target analytes in the sample based on the detected changes.

Abstract: An example biosensor is provided and includes a semiconductor sensing element, a first electrode and a second electrode located on a first plane of the sensing element with a first electric field being applied thereacross, a third electrode located on a second plane of the sensing element parallel to and removed from the first plane with a second electric field being applied across the first electrode and the third electrode perpendicular to the first electric field, and a dielectric substrate having a first portion that constrains a fluid including an analyte on a surface of the sensing element, and a second portion that facilitates dielectric separation of the fluid from the electrodes. The mutually perpendicular electric fields facilitate adjusting a height of a fluid-sensor interface comprising an electrical double layer in the fluid enabling detection and characterization of the analyte.