Patents Assigned to Ensemble Therapeutics Corporation
  • Macrocyclic compounds for inhibition of inhibitors of apoptosis
    Patent number: 9605022
    Abstract: There are disclosed compounds that modulate the activity of inhibitors of apoptosis (IAPs), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.
    Type: Grant
    Filed: November 7, 2013
    Date of Patent: March 28, 2017
    Assignee: Ensemble Therapeutics Corporation
    Inventors: Robert M. Borzilleri, Yong Zhang, Michael Miller, Andrew Fraley
  • Macrocyclic compounds for modulating IL-17
    Patent number: 9284283
    Abstract: The invention relates generally to macrocyclic compounds of formula I and their therapeutic use. More particularly, the invention relates to macrocyclic compounds that modulate the activity of IL-17 and/or are useful in the treatment of medical conditions, such as inflammatory diseases and other IL-17-associated disorders.
    Type: Grant
    Filed: February 1, 2013
    Date of Patent: March 15, 2016
    Assignee: Ensemble Therapeutics Corporation
    Inventors: Michael Taylor, Nicholas K. Terrett, William H. Connors, Cheri Snedeker, Kelley C. Shortsleeves, Benjamin A. Seigal, Stephen P. Hale, Timothy F. Briggs, Frank G. Favaloro, Jr., Tyler J. Cipriani, Dingxue Yan, Sethu L. Alexander, Atli Thorarensen, Li Xing
  • Macrocyclic compounds for inhibition of tumor necrosis factor alpha
    Patent number: 8338565
    Abstract: Disclosed herein are macrocyclic compounds and methods for their synthesis and use. In particular, macrocyclic compounds are disclosed that modulate the activity of tumor necrosis factor alpha and/or are useful in the treatment of medical conditions, such as, rheumatoid arthritis, psoriasis, and asthma.
    Type: Grant
    Filed: August 20, 2009
    Date of Patent: December 25, 2012
    Assignee: Ensemble Therapeutics Corporation
    Inventors: Jinbo Lee, Julian F. Bond, Nicholas Terrett, Frank G. Favaloro, Jr., Daniel Wang, Timothy F. Briggs, Benjamin Adam Seigal, Wei-Chuan Sun, Stephen P. Hale
  • Compositions and methods for biodetection by nucleic acid-templated chemistry
    Patent number: 8071388
    Abstract: The invention provides compositions and methods for the detection of biological targets, (e.g. nucleic acids and proteins) by nucleic acid-templated chemistry, for example, by generating fluorescent polymethine dyes.
    Type: Grant
    Filed: February 24, 2009
    Date of Patent: December 6, 2011
    Assignee: Ensemble Therapeutics Corporation
    Inventors: Yumei Huang, James M. Coull
  • Turn over probes and use thereof for nucleic acid detection
    Patent number: 7968289
    Abstract: The invention provides turnover probes for use in a variety of detection assays, for example, nucleic acid detection assays. In addition, the invention provides assays, for example, nucleic acid detection assays, using such turnover probes.
    Type: Grant
    Filed: May 3, 2006
    Date of Patent: June 28, 2011
    Assignee: Ensemble Therapeutics Corporation
    Inventors: James M. Coull, Lawrence A. Haff, Joshua A. Bittker, Xiaoyu Li, Larry W. McLaughlin