Patents Assigned to EnteroMedics Inc.
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Publication number: 20130238048Abstract: A therapy system for applying an electrical signal to an internal anatomical feature of a patient includes an implantable component and an external component. The medical device can be checked for safety issues by periodically initiating a sequence of tests of an H-bridge circuit, and, during each test, monitoring a current flow through a sensing resistor electrically connected between a sensing connection of the H-bridge circuit and a ground. Current flow through the sensing resistor indicates that both series electrical switches within at least one of the two pairs of series electrical switches are active during that test.Type: ApplicationFiled: March 11, 2013Publication date: September 12, 2013Applicant: EnteroMedics, Inc.Inventors: Al Almendinger, Gregory Pat Spar, Koen Jacob Weijand, Randy Maas, Steve Ellsworth
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Patent number: 8532787Abstract: A therapy system for applying an electrical signal to an internal anatomical feature of a patient includes an implantable component and an external component. The implantable component is configured to receive a selected therapy program and a selected therapy schedule from the external component. The implantable component is adapted to be selectively configured into one of a training mode and a delivery mode. The implantable component is configured to apply therapy to the internal anatomical feature in accordance with the selected therapy program and the selected therapy schedule when configured in the delivery mode. The implantable component is configured to simulate application of therapy when configured in the training mode.Type: GrantFiled: November 20, 2007Date of Patent: September 10, 2013Assignee: EnteroMedics Inc.Inventors: Scott Anthony Lambert, Adrianus Donders
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Patent number: 8521299Abstract: A treatment system includes a regulator implanted within a patient, a computing device storing at least one patient database associated with the patient in whom the regulator is implanted, and a data transfer device. The data transfer device provides bi-directional communication (e.g., voice communication) and a data exchange (e.g., a treatment history, a patient database, and operational instructions) between the regulator and the computing device. A programmer can obtain patient reports and/or default treatment values from the computing device based on the data exchange.Type: GrantFiled: November 9, 2011Date of Patent: August 27, 2013Assignee: EnteroMedics Inc.Inventors: Vineel Vallapureddy, Adrianus P. Donders, Satish Ramadhyani, Wu Wang, Hang Chan
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Publication number: 20130197600Abstract: At least one of a plurality of disorders of a patient characterized at least in part by vagal activity innervating at least one of a plurality of organs of the patient is treated by a method that includes positioning an electrode on a vagus nerve. An electrical signal is applied to the electrode to modulate vagal activity by an amount selected to treat the disorder. In some embodiments, the disorder is bulimia. The signal may be a blocking or a stimulation signal. In some embodiments, the signal is selected to, at least in part, downregulate neural activity on the vagus nerve.Type: ApplicationFiled: February 4, 2013Publication date: August 1, 2013Applicant: EnteroMedics Inc.Inventor: EnteroMedics Inc.
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Patent number: 8483838Abstract: Embodiments of an implantable medical device includes a loop antenna wound about an inner housing. The loop antenna may form a partial winding, a complete winding, or multiple windings about the inner housing. One or more additional antennae may be capacitively coupled to the loop antenna external to the inner housing to increase efficiency and decrease Return Loss Response of the implantable device. The additional antenna may be balanced or unbalanced antennae.Type: GrantFiled: February 28, 2011Date of Patent: July 9, 2013Assignee: EnteroMedics Inc.Inventors: David Nghiem, Scott Anthony Lambert, Jason William Sprain
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Patent number: 8483830Abstract: Various methods and apparatus for treating a condition associated with impaired glucose regulation in a subject comprising in one embodiment, applying a neural conduction block to a target nerve at a blocking site with the neural conduction block selected to at least partially block nerve pulses. In another embodiment, combinations of down-regulating and or up-regulating with or without pharmaceutical agents are used to treat impaired glucose regulation. In other embodiments, up-regulation or down-regulation of various nerves, such as the vagus and its branches, and the splanchnic is used to modify the production of GLP-1 and GIP, thereby controlling glucose levels. In yet further embodiments, combinations of down-regulating and or up-regulating with or without pharmaceutical agents are used to modify the production of GLP-1 and GIP, to treat impaired glucose regulation.Type: GrantFiled: April 3, 2009Date of Patent: July 9, 2013Assignee: EnteroMedics Inc.Inventors: Katherine S. Tweden, Mark B. Knudson, Richard R. Wilson, Arnold W. Thornton, Dennis Dong-won Kim
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Publication number: 20130079745Abstract: Various methods and apparatus for treating a condition associated with impaired glucose regulation in a subject comprising in one embodiment, applying a neural conduction block to a target nerve at a blocking site with the neural conduction block selected to at least partially block nerve pulses. In another embodiment, combinations of down-regulating and or up-regulating with or without pharmaceutical agents are used to treat impaired glucose regulation. In other embodiments, up-regulation or down-regulation of various nerves, such as the vagus and its branches, and the splanchnic is used to modify the production of GLP-1 and GIP, thereby controlling glucose levels. In yet further embodiments, combinations of down-regulating and or up-regulating with or without pharmaceutical agents are used to modify the production of GLP-1 and GIP, to treat impaired glucose regulation.Type: ApplicationFiled: November 20, 2012Publication date: March 28, 2013Applicant: EnteroMedics, Inc.Inventor: EnteroMedics, Inc.
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Patent number: 8372158Abstract: A method and apparatus are disclosed for treating obesity includes an artificial fistula created between gastrointestinal organs such as between the stomach and the colon. The method includes selecting an implant comprising a passageway having an internal lumen with an inlet end and an outlet end. The passageway is positioned passing through a first wall of first gastrointestinal organ (for example, passing through the wall of the stomach) and a second wall of a second gastrointestinal organ (for example, passing through the wall of the large intestine) with the inlet end disposed within an interior of the first gastrointestinal organ and with the outlet disposed within an interior of the second gastrointestinal organ.Type: GrantFiled: September 22, 2010Date of Patent: February 12, 2013Assignee: EnteroMedics, Inc.Inventors: Michael J. Levy, Michael L. Camilleri, Joseph A. Murray, William J. Sandborn
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Patent number: 8369952Abstract: At least one of a plurality of disorders of a patient characterized at least in part by vagal activity innervating at least one of a plurality of organs of the patient is treated by a method that includes positioning an electrode on a vagus nerve. An electrical signal is applied to the electrode to modulate vagal activity by an amount selected to treat the disorder. In some embodiments, the disorder is gastroparesis. The signal may be a blocking or a stimulation signal. In some embodiments, the signal is selected to a) at least in part, upregulate neural activity on the vagus nerve without triggering muscular contractility, and, b) increase pancreobilliary output.Type: GrantFiled: July 7, 2011Date of Patent: February 5, 2013Assignee: EnteroMedics, Inc.Inventors: Mark B. Knudson, Richard R. Wilson, Katherine S. Tweden, Timothy R. Conrad
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Patent number: 8326426Abstract: Example embodiments of an implantable device are configured to be implanted within a patient to provide medical therapy to the patient. In general, an implantable rechargeable device includes a rechargeable battery and an electronic board assembly arranged within a case and an antenna electrically coupled to the rechargeable battery. The antenna is configured to receive power and to transfer at least a portion of the received power to the rechargeable battery for recharging. A phase change material is arranged within the case around at least a portion of the electronic board assembly. The phase change material is configured to transition from a first phase to a second phase at a transition temperature when the insulating material absorbs heat (e.g., from the electronic board assembly).Type: GrantFiled: April 3, 2009Date of Patent: December 4, 2012Assignee: EnteroMedics, Inc.Inventors: Arnold W. Thornton, Adrianus P. Donders, Jason W. Sprain, Koen J. Weijand
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Patent number: 8140167Abstract: A therapy system for applying an electrical signal to an internal anatomical feature of a patient includes an implantable component and an external component. The external component can be configured into one of multiple selectable operating modes. The therapy system also may include a first external antenna configured to communicate with the implantable component and a second external antenna configured to communicate with the implantable component. Plugging one of the external antennas into the external component automatically configures the external component into one of the operating modes.Type: GrantFiled: November 20, 2007Date of Patent: March 20, 2012Assignee: EnteroMedics, Inc.Inventors: Adrianus Donders, Mark Raymond Stultz, Koen Jacob Weijand
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Publication number: 20120065706Abstract: A treatment system includes a regulator implanted within a patient, a computing device storing at least one patient database associated with the patient in whom the regulator is implanted, and a data transfer device. The data transfer device provides bi-directional communication (e.g., voice communication) and a data exchange (e.g., a treatment history, a patient database, and operational instructions) between the regulator and the computing device. A programmer can obtain patient reports and/or default treatment values from the computing device based on the data exchange.Type: ApplicationFiled: November 9, 2011Publication date: March 15, 2012Applicant: EnteroMedics Inc.Inventors: Vineel Vallapureddy, Adrianus P. Donders, Satish Ramadhyani, Wu Wang, Hang Chan
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Publication number: 20120041509Abstract: A method for treating at least one of a plurality of disorders characterized at least in part by vagal activity includes positioning an electrode around a body organ innervated by the vagus. An electrical signal is applied to the electrode to modulate vagal activity. The electrical signal is applied at a frequency selected for the signal to create a neural conduction block to the vagus with the neural conduction block selected to at least partially block nerve impulses on the vagus. The application of the electrical signal is discontinued. The application of the signal and the discontinuing of the signal are repeated with durations of the discontinuing and the application selected to treat the disorder.Type: ApplicationFiled: October 19, 2011Publication date: February 16, 2012Applicant: EnteroMedics Inc.Inventors: Mark B. Knudson, Richard R. Wilson, Katherine S. Tweden, Timothy R. Conrad
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Patent number: 8103349Abstract: An apparatus for applying a signal to a nerve for the treatment of a disorder includes a first electrode and a second electrode. Each of the electrodes is adapted to be secured to a nerve of a patient. A signal generator is electrically connected to each of the first and second electrodes. The signal generator is adapted to create a signal having a first waveform at the first electrode and a second waveform at the second electrode. The waveforms have parameters selected to block propagation of neural action potentials. The waveforms have a repeating pattern of cycles of pulses with a delay period between at least selected ones of said pulses. In one embodiment, the first and second waveforms are out of phase for a cycle of one of the waveforms to occur during a delay period of the other of the waveforms.Type: GrantFiled: December 15, 2009Date of Patent: January 24, 2012Assignee: EnteroMedics Inc.Inventors: Adrianus P. Donders, Koen J. Weijand, Mark B. Knudson
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Publication number: 20110307023Abstract: A system for designing a therapy or for treating a gastrointestinal disorder or a condition associated with excess weight in a subject comprising at least one electrode configured to be implanted within a body of the patient and placed at a vagus nerve, the electrode also configured to apply therapy to the vagus nerve upon application of a therapy cycle to the electrode; an implantable neuroregulator for placement in the body of the patient beneath the skin layer, the implantable neuroregulator being configured to generate a therapy cycle, wherein the therapy cycle comprises an on time during which an electrical signal is delivered, the electrical signal comprising: a) a set of pulses applied at a first selected frequency of about 150-10,000 Hz, wherein each pulse of the set of pulses has a pulse width of at least 0.01 milliseconds and less than the period of the first selected frequency.Type: ApplicationFiled: June 7, 2011Publication date: December 15, 2011Applicant: EnteroMedics Inc.Inventors: Katherine S. Tweden, Jonathan J. Waataja, Adrianus P. Donders, Mark B. Knudson
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Patent number: 8068918Abstract: A treatment system includes a regulator implanted within a patient, a computing device storing at least one patient database associated with the patient in whom the regulator is implanted, and a data transfer device. The data transfer device provides bidirectional communication (e.g., voice communication) and a data exchange (e.g., a treatment history, a patient database, and operational instructions) between the regulator and the computing device. A programmer can obtain patient reports and/or default treatment values from the computing device based on the data exchange.Type: GrantFiled: March 9, 2007Date of Patent: November 29, 2011Assignee: EnteroMedics Inc.Inventors: Vineel Vallapureddy, Adrianus P. Donders, Satish Ramadhyani, Wu Wang, Hang Chan
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Publication number: 20110282411Abstract: At least one of a plurality of gastrointestinal disorders is treated by stimulating an enteric nervous system of a patient to enhance a functional tone of the enteric nervous system. A treatment includes electrically stimulating a vagus nerve of the patient at a stimulation site proximal to at least one site of vagal innervation of a gastrointestinal organ. The electrical stimulation includes applying a stimulation signal at the stimulation site. An optional proximal electrical blocking signal is applied to the vagus nerve at a proximal blocking site proximal to the stimulation site. The proximal blocking signal is selected to at least partially block nerve impulses at the proximal blocking site.Type: ApplicationFiled: July 21, 2011Publication date: November 17, 2011Applicant: EnteroMedics IncInventors: Mark B. Knudson, Richard R. Wilson, Katherine S. Tweden, Timothy R. Conrad
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Publication number: 20110270344Abstract: At least one of a plurality of disorders of a patient characterized at least in part by vagal activity innervating at least one of a plurality of organs of the patient is treated by a method that includes positioning an electrode on a vagus nerve. An electrical signal is applied to the electrode to modulate vagal activity by an amount selected to treat the disorder. In some embodiments, the disorder is bulimia. The signal may be a blocking or a stimulation signal. In some embodiments, the signal is selected to, at least in part, downregulate neural activity on the vagus nerve.Type: ApplicationFiled: July 7, 2011Publication date: November 3, 2011Applicant: EnteroMedics Inc.Inventors: Mark B. Knudson, Richard R. Wilson, Katherine S. Tweden, Timothy R. Conrad
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Patent number: 8046085Abstract: A method for treating at least one of a plurality of disorders characterized at least in part by vagal activity includes positioning an electrode around a body organ innervated by the vagus. An electrical signal is applied to the electrode to modulate vagal activity. The electrical signal is applied at a frequency selected for the signal to create a neural conduction block to the vagus with the neural conduction block selected to at least partially block nerve impulses on the vagus. The application of the electrical signal is discontinued. The application of the signal and the discontinuing of the signal are repeated with durations of the discontinuing and the application selected to treat the disorder.Type: GrantFiled: October 20, 2010Date of Patent: October 25, 2011Assignee: EnteroMedics Inc.Inventors: Mark B. Knudson, Richard R. Wilson, Katherine S. Tweden, Timothy R. Conrad
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Patent number: 8010204Abstract: A system comprising: at least one electrode adapted to be placed on a vagus nerve below a vagal innervation of the heart; an implantable controller comprising an induction coil, at least one circuit for generating a neural conduction blocking signal connected to the at least one electrode, a battery, and a central processing unit comprising program storage and memory; and an external programmer configured to: communicate at least one parameter for the neural conduction blocking signal to the implantable controller, wherein the parameter is selected for the neural conduction blocking signal to i) at least partially downregulate the vagus nerve, ii) allow at least partial recovery of the nerve activity following discontinuation of the neural conduction blocking signal, and iii) reduce pancreatic and biliary output via inhibition of pancreo-biliary output; and an external coil adapted to be worn by the patient, wherein the external coil is connected to the external programmer, and is adapted to inductively couplType: GrantFiled: March 11, 2010Date of Patent: August 30, 2011Assignee: EnteroMedics Inc.Inventors: Mark B. Knudson, Richard R. Wilson, Katherine S. Tweden, Timothy R. Conrad