Patents Assigned to Enterovax Limited
  • Composite salmonella E. coli, Vibrio cholerae vaccine strains
    Patent number: 5110588
    Abstract: Composite bacterial strains useful as vaccines for the prophylactic treatment of enteric diseases are hybrids of Salmonella and E. coli in which E. coli-derived lipopolysaccharide cores expressed in a Salmonella organism serve as a scaffold upon which the O-antigen of yet another pathogenic bacterial species, such as Vibrio cholerae is constructed. Such strains, methods of their production, vaccine compositions comprising these strains, and methods of treating enteric disease with these vaccine compositions, are disclosed.
    Type: Grant
    Filed: September 1, 1989
    Date of Patent: May 5, 1992
    Assignee: Enterovax Limited
    Inventors: Renato Morona, Stephen R. Attridge
  • Bacterial strains harboring cloned genes controlling Vibrio cholerae O-antigen biosynthesis
    Patent number: 5066596
    Abstract: The invention relates to a fragment of DNA containing genes encoding the synthesis of the O-antigen of Vibrio cholerae serotypes Inaba or Ogawa and being at least 16 kb in length. The invention further related to a cosmid comprising a cloned DNA fragment containing genes encoding the synthesis of O-antigen of Vibrio cholerae serotypes Inaba or Ogawa and to a strain of E.coli that includes the fragment.
    Type: Grant
    Filed: July 31, 1987
    Date of Patent: November 19, 1991
    Assignee: Enterovax Limited
    Inventors: Paul A. Manning, Peter R. Reeves, Derrick Rowley