Abstract: A strain of Lactobacillus salivarius isolated from resected and washed human gastrointestinal tract inhibits a broad range of Gram positive and Gram negative microorganisms and secretes a product having antimicrobial activity into a cell-free supernatant. The activity is produced only by, growing cells and is destroyed by proteinase K and pronase E, the inhibitory properties of the strain and its secretory products being maintained in the presence of physiological concentrations of human bile and human gastric juice. The strain exhibits a broad-spectrum of activity against bacteria including Listeria, Staphylococcus, including methocillin resistant St. aureus (MRSA), and Bacillus, but does not inhibit many closely related lactobacilli. An antirmicrobial agent is obtained from the strain which has bacteriocin-like properties.
Type:
Application
Filed:
June 26, 2003
Publication date:
October 28, 2004
Applicant:
Enterprise Ireland and University College Cork-National University of Ireland, Cork
Inventors:
John Kevin Collins, Gerald Christopher O'Sullivan, Gerardine Mary Thornton, Marian Mary Geraldine O'Sullivan
Abstract: A strain of Lactobacillus salivarius isolated from resected and washed human gastrointestinal tract inhibits a broad range of Gram positive and Gram negative microorganisms and secretes a product having antimicrobial activity into a cell-free supernatant. The activity is produced only by growing cells and is destroyed by proteinase K and pronase E, the inhibitory properties of the strain and its secretory products being maintained in the presence of physiological concentrations of human bile and human gastric juice. The strain exhibits a broad-spectrum of activity against bacteria including Listeria, Staphylococcus, including methocillin resistant St. aureus (MRSA), and Bacillus, but does not inhibit many closely related lactobacilli. An antimicrobial agent is obtained from the strain which has bacteriocin-like properties.
Type:
Application
Filed:
June 26, 2003
Publication date:
February 26, 2004
Applicants:
Enterprise Ireland and University College Cork -, National University of Ireland, Cork
Inventors:
John Kevin Collins, Gerald Christopher O'Sullivan, Gerardine Mary Thornton, Marian Mary Geraldine O'Sullivan