Abstract: Detection systems and methods of use thereof, and, in particular, hyperspectral fluorescence systems and methods for detecting aerosolized viral biologics and/or carcinogenic compounds or elements. The system utilizes, and the method is, a non-invasive, immediate, and non-biohazard byproduct method (with the actual imaging to determination generally occurring in less than 3 seconds) with a throughput of the station in around ten seconds (which is allowing for sanitization of the station before and after each individual is tested).