Patents Assigned to Entropin, Inc.
  • Benzoylecgonine compositions and methods for producing them
    Patent number: 6790857
    Abstract: This invention provides a method for preparing a benzoylecgonine composition comprising the steps of: (a) contacting benzoylmethylecgonine and propylene glycol in the presence or absence of water to form a reaction mixture; (b) maintaining the reaction mixture at a temperature between about 50° and 100° C.; and (c) subsequently or simultaneously removing water from the reaction mixture. This invention also provides novel benzoylecgonine and methods for producing them.
    Type: Grant
    Filed: November 13, 2002
    Date of Patent: September 14, 2004
    Assignee: Entropin, Inc.
    Inventor: Nicholas James Archer
  • Covalently coupled benzoylecgonine, egconine and ecgonidine derivatives
    Patent number: 6482831
    Abstract: The present invention relates to a novel class of covalently coupled benzoylecgonine, ecgonine and ecgonidine derivatives that are useful for alleviating the symptoms of immunoregulatory disorders, neuromuscular disorders, joint disorders, connective tissue disorders, circulatory disorders and pain. Accordingly, this invention also relates to pharmaceutical compositions and methods for their use.
    Type: Grant
    Filed: April 26, 2000
    Date of Patent: November 19, 2002
    Assignee: Entropin, Inc.
    Inventors: James E. Wynn, Lowell M. Somers
  • Benzoylecgonine, ecgonine and ecgonidine derivatives
    Patent number: 6077848
    Abstract: The present invention relates to a novel class of covalently coupled benzoylecgonine, ecgonine and ecgonidine derivatives that are useful for alleviating the symptoms of immunoregulatory disorders, neuromuscular disorders, joint disorders, connective tissue disorders, circulatory disorders and pain. Accordingly, this invention also relates to pharmaceutical compositions and methods for their use.
    Type: Grant
    Filed: April 21, 1998
    Date of Patent: June 20, 2000
    Assignee: Entropin, Inc.
    Inventors: James E. Wynn, Lowell M. Somers
  • Benzoylecgonine, ecgonine and ecgonidine derivatives
    Patent number: 5763456
    Abstract: The present invention relates to a novel class of covalently coupled benzoylecgonine, ecgonine and ecgonidine derivatives that are useful for alleviating the symptoms of immunoregulatory disorders, neuromuscular disorders, joint disorders, connective tissue disorders, circulatory disorders and pain. Accordingly, this invention also relates to pharmaceutical compositions and methods for their use.
    Type: Grant
    Filed: February 28, 1997
    Date of Patent: June 9, 1998
    Assignee: Entropin, Inc.
    Inventors: James E. Wynn, Lowell M. Somers
  • Derivatives of benzoylecgonine, ecgonine and ecgonidine and methods for preparing and using same
    Patent number: 5663345
    Abstract: The present invention relates to a novel class of benzoylecgonine, ecgonine and ecgonidine derivatives which are useful for preventing and treating immunoregulatory disorders, neuromuscular. disorders, joint disorders, connective tissue disorders, circulatory disorders and pain. The compounds of this invention are conveniently obtained by chemical synthesis. Accordingly, this invention also relates to methods for preparing the benzoylecgonine, ecgonine and ecgonidine derivatives and to pharmaceutical compositions containing these derivatives.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: September 2, 1997
    Assignee: Entropin, Inc.
    Inventors: Lowell M. Somers, James E. Wynn
  • Derivatives of benzoylecgonine, ecgonine and ecgonidine and methods for preparing and using same
    Patent number: 5559123
    Abstract: The present invention relates to a novel class of benzoylecgonine, ecgonine and ecgonidine derivatives which are useful for preventing and treating immunoregulatory disorders, neuromuscular disorders, joint disorders, connective tissue disorders, circulatory disorders and pain. The compounds of this invention are conveniently obtained by chemical synthesis. Accordingly, this invention also relates to methods for preparing the benzoylecgonine, ecgonine and ecgonidine derivatives and to pharmaceutical compositions containing these derivatives.
    Type: Grant
    Filed: October 7, 1994
    Date of Patent: September 24, 1996
    Assignee: Entropin, Inc.
    Inventors: Lowell M. Somers, James E. Wynn
  • Covalently coupled benzoylecgonine ecgonine and ecgonidine
    Patent number: 5525613
    Abstract: The present invention relates to a novel class of covalently coupled benzoylecgonine, ecgonine and ecgonidine derivatives that are useful for alleviating the symptoms of immunoregulatory disorders, neuromuscular disorders, joint disorders, connective tissue disorders, circulatory disorders and pain. Accordingly, this invention also relates to pharmaceutical compositions and methods for their use.
    Type: Grant
    Filed: June 16, 1994
    Date of Patent: June 11, 1996
    Assignee: Entropin, Inc.
    Inventors: James E. Wynn, Lowell M. Somers
  • Derivatives of benzoylecgonine, ecgonine and their multiple pharmacological properties
    Patent number: 5376667
    Abstract: The present invention relates to a novel class of benzoylecgonine, ecgonine and ecgonidine derivatives which are useful for preventing and treating immunoregulatory disorders, neuromuscular disorders, joint disorders, connective tissue disorders, circulatory disorders and pain. The compounds of this invention are conveniently obtained by chemical synthesis. Accordingly, this invention also relates to methods for preparing the benzoylecgonine, ecgonine and ecgonidine derivatives and to pharmaceutical compositions containing these derivatives.
    Type: Grant
    Filed: December 31, 1992
    Date of Patent: December 27, 1994
    Assignee: Entropin, Inc.
    Inventors: Lowell M. Somers, James E. Wynn