Patents Assigned to Enumera Molecular, Inc.
  • Compositions and methods for isolation of cell-free DNA
    Patent number: 12188080
    Abstract: Provided herein are compositions and methods for isolating cell-free nucleic acid, e.g., cell-free DNA, from a sample. In particular embodiments, provided herein are compositions and methods using anti-dsDNA antibodies for isolating cell-free DNA from a sample, and for providing a sample of isolated cell-free DNA, e.g., for a nucleic acid assay. In particular embodiments, the technology relates to providing cell-free DNA from a maternal sample that is enriched for fetal cell-free fetal DNA.
    Type: Grant
    Filed: April 19, 2023
    Date of Patent: January 7, 2025
    Assignee: Enumera Molecular, Inc.
    Inventor: Jeffrey Perry
  • Methods, systems, and compositions for counting nucleic acid molecules
    Patent number: 11959129
    Abstract: Compositions and methods, systems, and kits for detecting and quantifying variations in numbers of molecules, particularly variations in gene dosage, e.g., due to gene duplication, or to variations from the normal euploid complement of chromosomes, e.g., trisomy of one or more chromosomes that are normally found in diploid pairs, without digital sequencing.
    Type: Grant
    Filed: October 13, 2021
    Date of Patent: April 16, 2024
    Assignee: Enumera Molecular, Inc.
    Inventors: Matthew Sekedat, Jeffrey Buis, Ronald David Beaubien, Jr., Sharat Singh, Jeff Perry, Steven Lockton, Chandni Jain, Natalie Mae Jameson-Kiesling
  • Methods, systems, and compositions for counting nucleic acid molecules
    Patent number: 11788121
    Abstract: Compositions and methods, systems, and kits for detecting and quantifying variations in numbers of molecules, particularly variations in gene dosage, e.g., due to gene duplication, or to variations from the normal euploid complement of chromosomes, e.g., trisomy of one or more chromosomes that are normally found in diploid pairs, without digital sequencing.
    Type: Grant
    Filed: December 7, 2021
    Date of Patent: October 17, 2023
    Assignee: Enumera Molecular, Inc.
    Inventors: Matthew Sekedat, Jeffrey Buis, Ronald David Beaubien, Sharat Singh, Jeff Perry
  • Methods for isolation of cell-free DNA using an anti-double-stranded DNA antibody
    Patent number: 11667955
    Abstract: Provided herein are compositions and methods for isolating cell-free nucleic acid, e.g., cell-free DNA, from a sample. In particular embodiments, provided herein are compositions and methods using anti-dsDNA antibodies for isolating cell-free DNA from a sample, and for providing a sample of isolated cell-free DNA, e.g., for a nucleic acid assay. In particular embodiments, the technology relates to providing cell-free DNA from a maternal sample that is enriched for fetal cell-free fetal DNA.
    Type: Grant
    Filed: October 21, 2021
    Date of Patent: June 6, 2023
    Assignee: Enumera Molecular, Inc.
    Inventor: Jeffrey Perry