Abstract: Containers suitable for storage and transport of regulated medical waste, including sharps and solid and semi-solid waste, which is disposable with the waste as by incineration, are provided by low cost paper, preferably corrugated paper, boxes having inserts which provide a mouth through which the waste items may be inserted. The insert has side walls which are attached to the side walls of the box near the top thereof. The insert has notches in the side walls along its bottom. A cover panel having tabs with spacing complimentary to the spacing of the notches is placed in the box upon the bottom of the insert with the tabs in the notches. The box may be lined with a plastic bag to provide leak resistance. The bag extends between the side walls of the insert and the side walls of the box and above the top of the box. The cover may also have a sleeve of flexible plastic material. To close the container, the plastic bag is tucked in so that it lies above the bottom of the insert.