Abstract: The invention is a device for separating blood cells from biological fluids, preferably plasma from whole blood. The invention includes a nonabsorbent, porous unitary support, which is desirably made of glass fiber, and a blood cell binding composition, such as a lectin. This device provides a test kit for measuring a plasma analyte in whole blood. This kit separates plasma from the whole blood, exposes the plasma to reactants that detect an analyte, and provides a chromatic or other result in response to exposure to the analyte. A desirable embodiment of the device has a cover plate over the reaction pad to apply uniaxialy pressure to the reaction pad which controls migration of plasma. The invention includes a method for separating plasma from whole blood and a method for detecting an analyte.

Abstract: A composite device for detecting or determining the presence of components in liquids is described. The device has, in combination at least a first and a second layer of porous material in contact with each other, at least one sample receiving site in said device and at least one reaction site connected to the sample receiving site via the second layer. A pre-determined liquid flow path in and through said layer is defined by liquid barrier means located in said layers whereby liquid deposited at the sample site is transferred to the reaction site along a path from one member to the other.

Abstract: A rotary fluid manipulator utilizable as a diagnostic device includes a porous body having fluid passages defined therein by fluid blocking means in the porosities of the body such as openings or slots in the body or compaction of areas of the porous body to define fluid passages therebetween. Various substances or binding partners such as receptors, immunoassay or other assay test materials and test specimens can be deposited on the porous body to permit various types of tests to be made by rotation of the manipulator to cause conjunctive centrifugal and wicking induced flow of fluids deposited thereupon.

Abstract: A rotary fluid manipulator utilizable as a diagnostic device includes a porous body having fluid passages defined therein by fluid blocking means in the porosities of the body such as openings or slots in the body or compaction of areas of the porous body to define fluid passages therebetween. Various substances or binding partners such as receptors, immunoassay or other assay test materials and test specimens can be deposited on the porous body to permit various types of test to be made by rotation of the manipulator to cause conjunctive centrifugal and wicking induced flow of fluids deposited thereupon.

Abstract: A test card incorporates a colorimetric indicator test to determine the presence of a minute amount of a specific substance in a liquid medium. The test card includes top and bottom sheets adhesively secured to an intermediate frame member which, together with the top and bottom sheets, defines a filter chamber having a flat filter therein which incorporates a test portion. The test portion of the filter has a binding substrate to which antibodies of the specific substance have been bound. This binding substrate is in communication with a test port. In the method of the invention a substance to be tested is administered through the test port and contains an unknown amount of antigen. After the sample is administered an aqueous solution of enzyme labelled antigen is administered and, subsequently, a liquid substrate is added to cause a color change in the filter below the test portion inversely proportional to the amount of antigen contained in the sample administered at the test port.

Abstract: A process and package product for preserving bacteriological culture media and gels is based on use of a sterilized air, liquid, and light impervious flexible wall pouch in which a Petri dish or similar device containing the medium or gel is stored and which is heat sealed after being evacuated and flushed with a inert gas to remove oxygen from within the dish and the pouch while in a vacuum chamber.

Abstract: A liquid suspension separator of simple, one-piece construction is provided for field tests such as bovine testing. The liquid suspension separator includes a housing having a separator chamber incorporating a filter body characterized by its ability to laterally filter the particulates of the suspension from the liquid component thereof. The housing incorporates eluant, liquid suspension and discharge ports and the liquid component of the suspension can be immediately collected to permit a test or tests to be run thereupon. One of the embodiments of the separator includes a test chamber which already incorporates a test specimen reactive to the liquid component of the suspension to permit an immediate test to be conducted in the field.