Patents Assigned to EnzRel Inc.
  • Covalent conjugates of biologically-active compounds with amino acids and amino acid derivatives for targeting to physiologically-protected sites
    Patent number: 7045543
    Abstract: This invention herein describes a method of facilitating the entry of drugs into cells and tissues at physiologically protected sites at pharmacokinetically useful levels and also a method of targeting drugs to physiologically protected sites in vivo. Also provided are drug conjugates with an amino acid or derivative thereof for facilitating such targeted drug delivery. The conjugates and methods of this invention provide an advance over other drug targeting methods known in the prior art, because the invention provides drug concentrations in such physiologically protected sites that can reach therapeutically-effective levels after administration of systemic levels much lower than are currently administered to achieve a therapeutic dose. This technology is appropriate for use with psychotropic, neurotropic, neurological, antibiotic, antibacterial, antimycotic, antiviral, antiproliferative or antineoplastic drugs, agents and conjugates, for rapid and efficient introduction of such agents across, e.g.
    Type: Grant
    Filed: November 5, 2001
    Date of Patent: May 16, 2006
    Assignee: EnzRel Inc.
    Inventors: Milton B. Yatvin, Richard L. Pederson
  • Liposome drug delivery of polycyclic, aromatic, antioxidant or anti-inflammatory compounds
    Patent number: 6824790
    Abstract: This invention comprises pharmaceutical compositions for administering a polycyclic, aromatic, antioxidant or anti-inflammatory compound to an animal. Particularly provided are proliposomal compositions that are advantageously used to deliver polycyclic, aromatic, antioxidant or anti-inflammatory compounds to the gastrointestinal tract after oral administration.
    Type: Grant
    Filed: January 9, 2003
    Date of Patent: November 30, 2004
    Assignee: EnzRel Inc.
    Inventor: Milton Yatvin
  • Liposome drug delivery
    Patent number: 6761901
    Abstract: This invention comprises pharmaceutical compositions for administering a biologically active compound to an animal. Particularly provided are proliposomal compositions that are advantageously used to deliver biologically active compounds to the gastrointestinal tract after oral administration.
    Type: Grant
    Filed: May 2, 2000
    Date of Patent: July 13, 2004
    Assignee: EnzRel Inc.
    Inventors: Guru V. Betageri, Milton B. Yatvin
  • Anti-mycobacterial compositions
    Patent number: 6689760
    Abstract: This invention provides compositions of matter, pharmaceutical compounds, methods of synthesizing such compounds and methods for using such compounds to treat animals infected with a pathogenic mycobacterium. The invention specifically provides compositions and pharmaceutical compositions thereof for the treatment of tuberculosis and other Mycobacterium-caused diseases.
    Type: Grant
    Filed: July 10, 2000
    Date of Patent: February 10, 2004
    Assignee: EnzRel Inc.
    Inventors: Milton B. Yatvin, Richard L. Pederson
  • Anti-mycobacterial compounds
    Patent number: 6664257
    Abstract: This invention provides compositions of matter, pharmaceutical compounds, methods of synthesizing such compounds and methods for using such compounds to treat animals infected with a pathogenic mycobacterium. The invention specifically provides compositions and pharmaceutical compositions thereof for the treatment of tuberculosis and other Mycobacterium-caused diseases.
    Type: Grant
    Filed: November 5, 2001
    Date of Patent: December 16, 2003
    Assignee: EnzRel Inc.
    Inventors: Milton B. Yatvin, Richard L. Pederson