Abstract: Disclosed are a method for preparing 1-palmitoyl-3-acetylglycerol in high purity and high yield without a purification process using a column chromatography, and a method for preparing 1-palmitoyl-2-linoleoyl-3-acetylglycerol in high purity and high yield using the same as a key intermediate. The method for preparing 1-palmitoyl-3-acetyl glycerol comprises the steps of: forming a reaction mixture including 1-palmitoyl-3-acetyl glycerol of the Formula 1 in the specification by reacting 1-palmitoylglycerol of the Formula 2 in the specification and an acetylating agent; and separating the optically active 1-palmitoyl-3-acetylglycerol by crystallizing the reaction mixture in a saturated hydrocarbon solvent having 5 to 7 carbon atoms.
Type:
Grant
Filed:
December 3, 2015
Date of Patent:
July 11, 2017
Assignee:
ENZYCHEM LIFESCIENCES CORPORATION
Inventors:
Tae-Suk Lee, Jin-Soo Yook, Chang-Hyun Yoo, Cheol-Min Lee, Eun-Kyung Kim, Ju-Cheol Lee