Patents Assigned to Enzyme Systems Products, Inc.
  • Peptide thioneamides as selective substrates for cysteine proteases
    Patent number: 4771123
    Abstract: Peptide thioneamides are provided as synthetic substrates for cysteine proteases. The compounds of the invention are peptides consisting of one or more blocked or unblocked amino acids wherein the terminal carboxy of the peptides are thionated and forms a thioneamide linkage with a fluorogenic or chromogenic leaving group. The alpha conbonyls of the remaining amino acids are thionated or unthionated. The invention includes methods and kits for using the peptide thioneamides.
    Type: Grant
    Filed: March 11, 1986
    Date of Patent: September 13, 1988
    Assignee: Enzyme Systems Products, Inc.
    Inventors: Kyujin Cho, David W. Rasnick