Abstract: Systems and methods for performing quantitative histopathology analysis for determining tissue potency are disclosed. According to some embodiments, a method training a tissue classifier is provided. According to the method, training the tissue classifier includes generating feature fingerprints of detected nuclei within slide images in a control library and clustering the slide images based on their corresponding feature fingerprints. According to some embodiments, a method for utilizing the trained tissue classifier is provided. According to the method, the trained tissue classifier determines whether tissue in an unknown slide image corresponds to slide images clustered during the training of the tissue classifier.
Type:
Application
Filed:
March 10, 2021
Publication date:
September 9, 2021
Applicant:
Enzyvant Therapeutics GmbH
Inventors:
Alex TRACY, Kristin MARKS, Michael Thomas JOHNSON, Thomas Stephen VILLANI
Abstract: Immune-phenotype markers for Farber disease and their uses are disclosed, as are methods of diagnosing and treating Farber disease based on these markers.
Abstract: Systems and methods for performing quantitative histopathology analysis for determining tissue potency are disclosed. According to some embodiments, a method training a tissue classifier is provided. According to the method, training the tissue classifier includes generating feature fingerprints of detected nuclei within slide images in a control library and clustering the slide images based on their corresponding feature fingerprints. According to some embodiments, a method for utilizing the trained tissue classifier is provided. According to the method, the trained tissue classifier determines whether tissue in an unknown slide image corresponds to slide images clustered during the training of the tissue classifier.
Type:
Grant
Filed:
July 2, 2019
Date of Patent:
April 13, 2021
Assignee:
ENZYVANT THERAPEUTICS GMBH
Inventors:
Alex Tracy, Kristin Marks, Michael Thomas Johnson, Thomas Stephen Villani
Abstract: Immune-phenotype markers for Farber disease and their uses are disclosed, as are methods of diagnosing and treating Farber disease based on these markers.