Abstract: A device (1) for manufacturing a three-dimensional object by a layer wise solidification of a building material at positions in the respective layers that correspond to the object is provided. A feed (96) that supplies the building material to a building space (10) in the device (1) and at least two filler portions (98a, 98b) that are provided at the feed (96) and are independent from one another are provided, wherein one connector (99a, 99b) is provided for each building material supply container (100a, 100b) in order to supply the building material from outside of the device (1).

Abstract: A method is provided, by which a three-dimensional object is manufactured by a subsequent solidification of layers of a building material in powder form at the positions in the respective layer that corresponds to the cross-section of the object by means of the action of a laser or another energy source, wherein as building material in powder form a material is used which contains the old powder that has remained as unsolidified powder in the manufacturing of one or more previously formed objects and a proportion of new powder that has not been used before in any manufacturing process, characterized in that the building material in powder form is mechanically consolidated when a layer is applied.

Abstract: The invention describes powders for use in the production of spatial structures, i.e. molded bodies, using layer build-up methods, as well as methods for their efficient production. The powders have the special feature that they have good flow behavior, for one thing, and at the same time, have such a composition that the molded body that can be produced with the powder, using rapid prototyping, has significantly improved mechanical and/or thermal properties. According to a particularly advantageous embodiment, the powder has a first component that is present in the form of essentially spherical powder particles, which is formed by a matrix material, and at least one further component in the form of stiffening and/or reinforcing fibers, which are preferably embedded in the matrix material.

Abstract: A process for the preparation in high yields and purity of the compound 6-(7-((1-aminocyclopropyl)methoxy)-6-methoxyquinolin-4-yloxy)-N-methyl-1-naphthamide of formula (I) and of the pharmaceutically acceptable salts thereof is described. The process has various advantages over those previously described, in particular it avoids the use of acyl azide intermediates and their Curtius rearrangement. Novel intermediates useful for the preparation of compound (I) are also described.

Abstract: A method for measuring geometric quantities intrinsic to an anatomical system of a patient, based on two stereoscopic images. Registration data are received on each of the two stereoscopic images. By using geometric calibration information, a three-dimensional geometric primitive is determined defined by at least a portion of the received registration data. Based on the three-dimensional geometric primitive, a value of geometric quantity intrinsic to the anatomical system is computed.

Abstract: Provided herein are compositions and methods for the design of synthetic regulatory sequences and for subsequent modulation of neural pathways.

Abstract: A method is provided, by which a three-dimensional object is manufactured by a subsequent solidification of layers of a building material in powder form at the positions in the respective layer that corresponds to the cross-section of the object by means of the action of a laser or another energy source, wherein as building material in powder form a material is used which contains the old powder that has remained as unsolidified powder in the manufacturing of one or more previously formed objects and a proportion of new powder that has not been used before in any manufacturing process, characterized in that the building material in powder form is mechanically consolidated when a layer is applied.

Abstract: A process for the preparation in high yields and purity of the compound 6-(7-4(1-aminocyclopropyl)methoxy)-6-methoxyquinolin-4-yloxy)-N-methyl-1-naphthamide of formula (I) and of the pharmaceutically acceptable salts thereof is described. The process has various advantages over those previously described, in particular it avoids the use of acyl azide intermediates and their Curtius rearrangement. Novel intermediates useful for the preparation of compound (I) are also described.

Abstract: Photonic integrated circuits (PICs) are based on quantum cascade (QC) structures. In embodiment methods and corresponding devices, a QC layer in a wave confinement region of an integrated multi-layer semiconductor structure capable of producing optical gain is depleted of free charge carriers to create a low-loss optical wave confinement region in a portion of the structure. Ion implantation may be used to create energetically deep trap levels to trap free charge carriers. Other embodiments include modifying a region of a passive, depleted QC structure to produce an active region capable of optical gain. Gain or loss may also be modified by partially depleting or enhancing free charge carrier density. QC lasers and amplifiers may be integrated monolithically with each other or with passive waveguides and other passive devices in a self-aligned manner. Embodiments overcome challenges of high cost, complex fabrication, and coupling loss involved with material re-growth methods.

Abstract: A method for coating the surfaces of three-dimensional objects with a coating agent is provided, which method is characterized by a blasting of the three-dimensional object, wherein a grainy blasting material that has been mixed with the coating agent is used as blasting medium.

Abstract: The Cellular GPRS system includes a cellular-based Glucometer (CBG) for blood glucose monitoring, a pedometer for exertion measurement, combined with user-entered dietary or other diabetes-relevant information. Data from all inputs is transmitted over a cellular network, using a GPRS or other wireless link. The data is preferably stored in the device prior to being transmitted wirelessly over the cellular airway to a central computer server. The remote computer server will evaluate the data received and respond with a data packet (making recommendations on further glucose measurement, exercise, diet, insulin requirements or other).

Abstract: A laser-assisted method for fully or partially separating tissue such as collagen-containing tissue is provided. In one embodiment, the method pertains to a capsolurorhexis whereby the laser-assisted method is applied to the lens capsule. A light-absorbing agent is added into or onto the tissue. A light beam with a wavelength capable of being absorbed by the light absorbing agent is then directed at the tissue to cause a thermal effect at the tissue following a predetermined closed curve with the goal to avoid irregularity or potential tears in the resulting rim of the tissue.

Abstract: An apparatus for manufacturing a three-dimensional object (3) by applying and solidifying a powdery constituent material (3a) layer by layer at positions corresponding to the respective cross sectional area of the object (3) in the respective layer by exposure to a laser (7) or another energy source comprises a heating or cooling element (22) supplying heat to or removing heat away from the constituent material (3a) applied layer by layer. For smoothing the temperature distribution, an intermediate layer (23) having a highly anisotropic heat conductivity is provided.

Abstract: A radiographic imaging device includes a gas avalanche detector detecting and locating X-ray or gamma ray ionizing radiation.

Abstract: Method of manufacturing a three-dimensional object according to which the object is built layer-wise by solidification of a building material, wherein a test specimen is built which is excited to oscillate after being built and wherein natural frequencies of the oscillations are determined.

Abstract: A bottle opener for a closure cap for a bottle neck, includes a hood equipped with a first hook including a contact surface with a lower surface of the closure cap, and a transmission lever hinged onto the hood and provided with a gripping section and a working section able to come to bear against an upper surface of the closure cap. It is also provided with two other hooks which include a contact surface with the lower surface and which are offset in the circumferential direction on both sides of the position diametrically opposite the first hook, by an angle of less than 90°, typically ranging between 40° and 80°, and preferably ranging between 40° and 50°.

Abstract: Method of manufacturing a three-dimensional object of a building material by an additive layer-wise building method, wherein based on material parameters of the building material and predetermined characteristics of the object to be manufactured, an internal structure of the object having a grid structure calculated, and the three-dimensional object is manufactured with this internal structure by the additive layer-wise building method, so that it comprises the predetermined characteristics.

Abstract: A three-dimensional object is manufactured from a powder of polymer material by selective sintering process by means of electromagnetic radiation of the powder, wherein the powder comprises a preselected polymer or copolymer and is subjected to selective sintering such that the manufactured three-dimensional object has a final crystallinity which is in such a range that the balance of properties, in particular mechanical properties including Young's modulus, tensile strength and elongation at break, is improved.

Abstract: Method and device for producing a 3D object by means of a generative 3D-method, for example, selective laser sintering (SLS) and selective laser melting (SLM). An infrared sensor can be cross-flown by a tempered fluid in order to prevent the infrared sensor, which is provided in the process chamber of the device, from being impaired by monomer deposits, oligomers or solid material particles during the construction thereof.

Abstract: A laser-assisted method for fully or partially separating tissue such as collagen-containing tissue is provided. In one embodiment, the method pertains to a capsolurorhexis whereby the laser-assisted method is applied to the lens capsule. A light-absorbing agent is added into or onto the tissue. A light beam with a wavelength capable of being absorbed by the light absorbing agent is then directed at the tissue to cause a thermal effect at the tissue following a predetermined closed curve with the goal to avoid irregularity or potential tears in the resulting rim of the tissue.