Patents Assigned to EPEIUS BIOTECHNOLOGIES
  • Method for identifying and treating a patient having tumor lesions comprising administering a gene therapy retroviral vector particle comprising a mutated HSV-thymidine kinase (HSV-TK) polynucleotide
    Patent number: 9999683
    Abstract: Nucleic acid sequences encoding improved Herpes Simplex Virus Thymidine Kinases are provided, including their use in diagnostic and therapeutic applications. The thymidine kinases may be mutated using conservative mutations, non-conservative mutations, or both. Also provided are gene therapeutic systems, including viral and retroviral particles.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: June 19, 2018
    Assignee: EPEIUS BIOTECHNOLOGIES CORPORATION
    Inventors: John P. Levy, Rebecca A. Reed, Joseph McNulty, Robert G. Johnson, Jr.
  • Thymidine kinase gene
    Patent number: 9925276
    Abstract: Nucleic acid sequences encoding improved Herpes Simplex Virus Thymidine Kinases are provided, including their use in diagnostic and therapeutic applications. The thymidine kinases may be mutated using conservative mutations, non-conservative mutations, or both. Also provided are gene therapeutic systems, including viral and retroviral particles.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: March 27, 2018
    Assignee: EPEIUS BIOTECHNOLOGIES CORPORATION
    Inventors: John P. Levy, Rebecca A. Reed, Joseph McNulty, Robert G. Johnson, Jr.
  • Pathotropic targeted gene delivery system for cancer and other disorders
    Patent number: 9017659
    Abstract: Systems for pathotropic (disease-seeking) targeted gene delivery are provided, including viral particles with extremely high titers. In particular, the viral particles are engineered to specifically deliver therapeutic or diagnostic agents to a disease site, such as cancer metastic sites. Personalized dosing regimens are also provided to treat diseases such as cancer efficaciously with reduced adverse side effects.
    Type: Grant
    Filed: November 5, 2007
    Date of Patent: April 28, 2015
    Assignee: Epeius Biotechnologies Corporation
    Inventors: Frederick L. Hall, Erlinda M. Gordon
  • THYMIDINE KINASE DIAGNOSTIC ASSAY FOR GENE THERAPY APPLICATIONS
    Publication number: 20140294772
    Abstract: Nucleic acid sequences encoding improved Herpes Simplex Virus Thymidine Kinases are provided, including their use in diagnostic and therapeutic applications. The thymidine kinases may be mutated using conservative mutations, non-conservative mutations, or both. Also provided are gene therapeutic systems, including viral and retroviral particles.
    Type: Application
    Filed: March 14, 2014
    Publication date: October 2, 2014
    Applicant: Epeius Biotechnologies Corporation
    Inventors: John P. LEVY, Rebecca A. REED, Joseph MCNULTY, Robert G. JOHNSON, JR.
  • TRANSGENE DELIVERING RETROVIRUS TARGETING COLLAGEN EXPOSED AT SITE OF TISSUE INJURY
    Publication number: 20130331547
    Abstract: A viral or non-viral vector particle having a modified viral surface protein wherein the viral surface protein is modified to include a targeting polypeptide including a binding region which binds to an extracellular matrix component. Such vector particles are useful in delivering genes encoding therapeutic agents to cells located at the site of an exposed extracellular matrix component.
    Type: Application
    Filed: August 5, 2013
    Publication date: December 12, 2013
    Applicant: EPEIUS BIOTECHNOLOGIES
    Inventors: Frederick L. Hall, Erlinda Maria Gordon
  • TARGETED NANOPARTICLES FOR CANCER AND OTHER DISORDERS
    Publication number: 20120027727
    Abstract: Targeted gene therapeutic systems are provided for the treatment of cancer, including viral particles. The viral particles are engineered to specifically deliver therapeutic or diagnostic agents to a disease site, such as cancer metastatic sites. Localized dosing regimens are provided to treat diseases such as cancer.
    Type: Application
    Filed: July 15, 2011
    Publication date: February 2, 2012
    Applicant: Epeius Biotechnologies Corporation
    Inventors: FREDERICK L. HALL, ERLINDA M. GORDON