Abstract: Methods for forming sustained release microspheres and the products produced thereby are provided. The microspheres have a smooth surface that includes a plurality of channel openings that are less than 1000 angstroms in diameter.
Type:
Grant
Filed:
October 18, 1999
Date of Patent:
October 1, 2002
Assignee:
Epic Therapeutics, Inc.
Inventors:
Terrence L. Scott, Larry R. Brown, Frank J. Riske, Charles D. Blizzard, Julia Rashba-Step
Abstract: Methods relating to the field of biochemistry and more specifically relating to microparticles for use in diagnostics, therapeutics, and research are provided.
Type:
Grant
Filed:
January 14, 2000
Date of Patent:
July 31, 2001
Assignee:
Epic Therapeutics, Inc.
Inventors:
James E. Woiszwillo, Larry R. Brown, Terrence L. Scott, Jie Di, Judith Sudhalter, Charles D. Blizzard, Frank J. Riske
Abstract: Microparticles formed by mixing a macromolecule with a polymer at a pH near the isoelectric point of the macromolecule and incubating the mixture in the presence of an energy source for a predetermined length of time. The microparticles are composed of homogeneously distributed, intertwined macromolecule and polymer. Each microparticle allows aqueous fluids to enter and allows solubilized macromolecule and polymer to exit the microparticle and may be formulated to provide a sustained release of macromolecule and polymer from the interior of the microparticle when placed in an appropriate aqueous medium, such as under physiological conditions. Methods of production and methods of use for research, diagnostics and therapeutics are provided.
Type:
Grant
Filed:
August 19, 1996
Date of Patent:
July 18, 2000
Assignee:
Epic Therapeutics, Inc.
Inventors:
James E. Woiszwillo, Larry R. Brown, Terrence L. Scott, Jie Di, Judith Sudhalter, Charles D. Blizzard
Abstract: Microparticles formed by mixing a macromolecule with a polymer at a pH near the isoelectric point of the macromolecule and incubating the mixture in the presence of an energy source for a predetermined length of time. The microparticles are composed of homogeneously distributed, intertwined macromolecule and polymer. Each microparticle allows aqueous fluids to enter and allows solubilized macromolecule and polymer to exit the microparticle and may be formulated to provide a sustained release of macromolecule and polymer from the interior of the microparticle when placed in an appropriate aqueous medium, such as under physiological conditions. Methods of production and methods of use for research, diagnostics and therapeutics are provided.
Type:
Grant
Filed:
December 14, 1998
Date of Patent:
November 9, 1999
Assignee:
Epic Therapeutics, Inc.
Inventors:
James E. Woiszwillo, Larry R. Brown, Terrence L. Scott, Jie Di, Judith Sudhalter, Charles D. Blizzard, Frank J. Riske
Abstract: Microparticles formed by mixing a macromolecule with a polymer at a pH near the isoelectric point of the macromolecule and incubating the mixture in the presence of an energy source for a predetermined length of time. The microparticles are composed of homogeneously distributed, intertwined macromolecule and polymer. Each microparticle allows aqueous fluids to enter and allows solubilized macromolecule and polymer to exit the microparticle and may be formulated to provide a sustained release of macromolecule and polymer from the interior of the microparticle when placed in an appropriate aqueous medium, such as under physiological conditions. Methods of production and methods of use for research, diagnostics and therapeutics are provided.
Type:
Grant
Filed:
August 19, 1996
Date of Patent:
December 15, 1998
Assignee:
Epic Therapeutics, Inc.
Inventors:
James E. Woiszwillo, Larry R. Brown, Terrence L. Scott, Jie Di, Judith Sudhalter, Charles D. Blizzard