Abstract: The present disclosure provides one or more engineered nucleases and systems, compositions, and methods thereof, wherein the one or more engineered nucleases can be used to effect binding, cleaving, and/or editing a target polynucleotide sequence. The one or more engineered nucleases can be engineered variants of a small CRISPR/Cas protein.
Type:
Grant
Filed:
July 7, 2023
Date of Patent:
August 6, 2024
Assignee:
Epicrispr Biotechnologies, Inc.
Inventors:
Xiao Yang, Lei S. Qi, Vincent Cutillas, Gabriella Alvarez, Tabitha Tcheau, Daniel O. Hart