Abstract: Heteroclitic analogs of Class I epitopes are prepared by providing conservative or semi-conservative amino acid substitutions at positions 3 and/or 5 and/or 7 of these epitopes. The analogs are useful in eliciting immune responses with respect to the corresponding wildtype epitopes.
Type:
Grant
Filed:
April 5, 2002
Date of Patent:
June 3, 2014
Assignee:
Epimunne Inc.
Inventors:
Shabnam Tangri, Alessandro Sette, Glenn Ishioka, John D. Fikes