Abstract: The present invention provides compositions including polypeptides having the characteristics of polypeptides expressed by a reference microbe such E. coli or Salmonella. Examples of Salmonella strains that can be used include, for instance, S. enterica serovar Newport, S. enterica serovar Enteritidis, S. enterica serovar Typhimurium, and S. enterica serovar Dublin. Also provided are compositions including polypeptides having a particular molecular weight and a mass fingerprint that includes polypeptide fragments having a particular set of masses, or polypeptides having an amino acid sequence with at least about 95% identity with an amino acid sequence, wherein the polypeptide has seroreactive activity. The present invention also provides methods of making and methods of using such compositions.
Type:
Grant
Filed:
July 14, 2015
Date of Patent:
October 11, 2016
Assignee:
EPITOPIX LLC
Inventors:
Daryll A. Emery, Darren E. Straub, Laura Wonderling
Abstract: The present invention provides isolated polypeptides isolatable from a Fusobacterium spp. Also provided by the present invention are compositions that include one or more of the polypeptides, and methods for making and methods for using the polypeptides.
Abstract: The present invention provides isolated polypeptides isolatable from a Yersinia spp. Also provided by the present invention are compositions that include one or more of the polypeptides, and methods for making and methods for using the polypeptides.
Type:
Grant
Filed:
November 5, 2015
Date of Patent:
May 31, 2016
Assignee:
EPITOPIX, LLC
Inventors:
Daryll A. Emery, Darren E. Straub, Laura Wonderling
Abstract: The present invention provides isolated polypeptides isolatable from a Staphylococcus spp. Also provided by the present invention are compositions that include one or more of the polypeptides, and methods for making and methods for using the polypeptides.
Type:
Grant
Filed:
January 29, 2015
Date of Patent:
February 23, 2016
Assignee:
EPITOPIX LLC
Inventors:
Daryll A. Emery, Darren E. Straub, Lisa L. Herron-Olson, Laura Wonderling
Abstract: The present invention provides isolated polypeptides isolatable from a Yersinia spp. Also provided by the present invention are compositions that include one or more of the polypeptides, and methods for making and methods for using the polypeptides.
Type:
Grant
Filed:
July 7, 2015
Date of Patent:
December 29, 2015
Assignee:
EPITOPIX LLC
Inventors:
Daryll A. Emery, Darren E. Straub, Laura Wonderling
Abstract: The present invention provides compositions including polypeptides having the characteristics of polypeptides expressed by a reference microbe such E coli or Salmonella. Examples of Salmonella strains that can be used include, for instance, S. enterica serovar Newport, S. enterica serovar Enteritidis, S. enterica serovar Typhimurium, and S. enterica serovar Dublin. Also provided are compositions including polypeptides having a particular molecular weight and a mass fingerprint that includes polypeptide fragments having a particular set of masses, or polypeptides having an amino acid sequence with at least about 95% identity with an amino acid sequence, wherein the polypeptide has seroreactive activity. The present invention also provides methods of making and methods of using such compositions.
Type:
Grant
Filed:
November 12, 2008
Date of Patent:
August 18, 2015
Assignee:
EPITOPIX LLC
Inventors:
Daryll A. Emery, Darren E. Straub, Laura Wonderling
Abstract: The present invention provides isolated polypeptides isolatable from a Yersinia spp. Also provided by the present invention are compositions that include one or more of the polypeptides, and methods for making and methods for using the polypeptides.
Type:
Grant
Filed:
October 8, 2013
Date of Patent:
August 18, 2015
Assignee:
EPITOPIX, LLC
Inventors:
Daryll A. Emery, Darren E. Straub, Laura Wonderling
Abstract: The present invention provides isolated polypeptides isolatable from a Yersinia spp. Also provided by the present invention are compositions that include one or more of the polypeptides, and methods for making and methods for using the polypeptides.
Type:
Grant
Filed:
October 8, 2013
Date of Patent:
July 21, 2015
Assignee:
Epitopix, LLC
Inventors:
Daryll A. Emery, Darren E. Straub, Laura Wonderling
Abstract: The present invention provides isolated polypeptides isolatable from a Yersinia spp. Also provided by the present invention are compositions that include one or more of the polypeptides, and methods for making and methods for using the polypeptides.
Type:
Grant
Filed:
October 8, 2013
Date of Patent:
July 21, 2015
Assignee:
Epitopix, LLC
Inventors:
Daryll A. Emery, Darren E. Straub, Laura Wonderling
Abstract: The present invention provides compositions including siderophore receptor polypeptides and porins from gram negative microbes, and preferably, lipopolysaccharide at a concentration of no greater than about 10.0 endotoxin units per milliliter. The present invention also provides methods of making and methods of using such compositions.
Abstract: The present invention provides isolated polypeptides isolatable from a Staphylococcus spp. Also provided by the present invention are compositions that include one or more of the polypeptides, and methods for making and methods for using the polypeptides.
Type:
Grant
Filed:
January 31, 2012
Date of Patent:
February 24, 2015
Assignee:
Epitopix, LLC
Inventors:
Daryll A. Emery, Darren E. Straub, Laura Wonderling, Lisa L. Herron Olson
Abstract: The present invention provides isolated polypeptides isolatable from a Staphylococcus spp. Also provided by the present invention are compositions that include one or more of the polypeptides, and methods for making and methods for using the polypeptides.
Type:
Application
Filed:
January 31, 2012
Publication date:
January 22, 2015
Applicant:
Epitopix, LLC
Inventors:
Daryll A. Emery, Darren E. Straub, Laura Wonderling, Lisa L. Herron Olson
Abstract: The present invention provides isolated polypeptides isolatable from a Yersinia spp. Also provided by the present invention are compositions that include one or more of the polypeptides, and methods for making and methods for using the polypeptides.
Type:
Application
Filed:
October 8, 2013
Publication date:
June 19, 2014
Applicant:
EPITOPIX, LLC
Inventors:
Daryll A. Emery, Darren E. Straub, Laura Wonderling
Abstract: The present invention provides isolated polypeptides isolatable from a Yersinia spp. Also provided by the present invention are compositions that include one or more of the polypeptides, and methods for making and methods for using the polypeptides.
Type:
Application
Filed:
October 8, 2013
Publication date:
June 12, 2014
Applicant:
EPITOPIX, LLC.
Inventors:
Daryll A. Emery, Darren E. Straub, Laura Wonderling
Abstract: The present invention provides isolated polypeptides isolatable from a Yersinia spp. Also provided by the present invention are compositions that include one or more of the polypeptides, and methods for making and methods for using the polypeptides.
Type:
Application
Filed:
October 8, 2013
Publication date:
June 12, 2014
Applicant:
EPITOPIX, LLC.
Inventors:
Daryll A. Emery, Darren E. Straub, Laura Wonderling
Abstract: The present invention provides isolated polypeptides isolatable from a Staphylococcus spp. Also provided by the present invention are compositions that include one or more of the polypeptides, and methods for making and methods for using the polypeptides.
Type:
Grant
Filed:
March 18, 2008
Date of Patent:
April 29, 2014
Assignee:
Epitopix, LLC.
Inventors:
Daryll A. Emery, Darren E. Straub, Laura Wonderling, Lisa L. Herron Olson
Abstract: The present invention provides isolated polypeptides isolatable from a Staphylococcus spp. Also provided by the present invention are compostions that include one or more of the polypeptides, and methods for making and methods for using the polypeptides.
Type:
Grant
Filed:
November 17, 2008
Date of Patent:
April 29, 2014
Assignee:
Epitopix, LLC
Inventors:
Daryll A. Emery, Darren E. Straub, Laura Wonderling, Lisa L. Herron Olson
Abstract: The present invention provides compositions including siderophore receptor polypeptides and porins from gram negative microbes, and preferably, lipopolysaccharide at a concentration of no greater than about 10.0 endotoxin units per milliliter. The present invention also provides methods of making and methods of using such compositions, including inducing the production of antibody in an animal.
Abstract: The present invention provides isolated polypeptides isolatable from a Staphylococcus spp. Also provided by the present invention are compositions that include one or more of the polypeptides, and methods for making and methods for using the polypeptides.
Type:
Application
Filed:
July 1, 2013
Publication date:
January 2, 2014
Applicant:
Epitopix, LLC
Inventors:
Daryll A. Emery, Darren E. Straub, Laura Wonderling, Lisa L. Herron Olson
Abstract: The present invention provides compositions including antibodies that specifically bind at least one siderophore receptor polypeptide from a gram positive microbe. The present invention also provides methods of making and methods of using such compositions.