Patents Assigned to Epoch Pharmaceuticals
  • Sterol modified oligonucleotide duplexes having anticancer activity
    Patent number: 5646126
    Abstract: Oligonucleotides having approximately 8 to 18 nucleotide units and a 3'-tail which includes asteroid structure attached to the 3'-end through the A ring of the steroid skeleton and which form substantially stable duplexes at physiological temperature, have selective cytotoxic activity against certain tumor cell lines.
    Type: Grant
    Filed: February 28, 1994
    Date of Patent: July 8, 1997
    Assignees: Epoch Pharmaceuticals, Yale University
    Inventors: Yung-chi Cheng, Eugeny A. Lukhtanov, Rich B. Meyer, Jr., Balakrishna S. Pai, Michael W. Reed, James H. Zhou