Patents Assigned to Eprova Akteingesellschaft
  • Process for the preparation of (6S)- and (6R)-tetrahydrofolic acid
    Patent number: 5324836
    Abstract: For the preparation of (6S)- and (6R)-tetrahydrofolic acid and their addition salts with a sulfonic acid or with sulfuric acid, (6R,S)-tetrahydrofolic acid is reacted with a sulfonic acid or with sulfuric acid, the resulting acid addition salt is fractionally crystallized and, if desired, the (6S)- or (6R)-tetrahydrofolic acid is liberated from the resulting diastereomeric acid addition salts by treatment with a base and isolated.
    Type: Grant
    Filed: April 8, 1993
    Date of Patent: June 28, 1994
    Assignee: Eprova Akteingesellschaft
    Inventors: Hans R. Muller, Martin Ulmann, Josef Conti, Gunter Murdel