Abstract: Pure and extremely stable crystalline (6S)- and (6R)-tetrahydrofolic acids, absolutely inert even when exposed to air and elevated temperature without stabilizers being added, are prepared by a crystallization process at a pH of ≧3.5 for the preparation of crystalline (6S)-tetrahydrofolic acid and at a pH of ≧2 for the preparation of crystalline (6R)-tetrahydrofolic acid.
Type:
Application
Filed:
January 8, 2001
Publication date:
May 31, 2001
Applicant:
EPROVA AKTIENGESELLSCGAFT
Inventors:
Hans Rudolf Muller, Martin Ulmann, Rudolf Moser, Thomas Ammann