Patents Assigned to Epsilon
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Publication number: 20250116506Abstract: A system for confocal-chromatic line distance measurement, comprising a line light source (2), an aperture (3), a confocal-chromatic, preferably rotationally symmetrical, measurement lens (6), and a spectrometer (14), preferably a 2D spectrometer, wherein the illumination beam path extends from the light source (2) via the aperture (3) and a first region (5) of the measurement lens (6) to the measurement object (9) and wherein the imaging beam path extends from the measurement object (6) via a second region (11) of the measurement lens (6) to the spectrometer (14). Furthermore, a method for confocal-chromatic line distance measurement is specified.Type: ApplicationFiled: December 22, 2022Publication date: April 10, 2025Applicant: MICRO-EPSILON OPTRONIC GMBHInventors: Tobias OTTO, Christoph GRÜBER, Torsten STAUTMEISTER
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Publication number: 20250019460Abstract: Provided are a peptide consisting of three complementarity determining regions and four framework regions, in which a framework 1 comprises an amino acid sequence represented by SEQ ID NO: 1, a framework 2 comprises an amino acid sequence represented by SEQ ID NO: 2, a framework 3 comprises an amino acid sequence represented by SEQ ID NO: 7, a framework 4 comprises an amino acid sequence represented by SEQ ID NO: 32, a complementarity determining region 1 is an amino acid sequence consisting of 10 amino acids, a complementarity determining region 2 is an amino acid sequence consisting of 16 or 17 amino acids, and a complementarity determining region 3 is an amino acid sequence consisting of 6, 12 or 15 amino acids; and a peptide library including the peptide.Type: ApplicationFiled: November 30, 2022Publication date: January 16, 2025Applicants: EPSILON MOLECULAR ENGINEERING INC., MITSUI KNOWLEDGE INDUSTRY CO., LTDInventors: Taihei Murakami, Shigefumi Kumachi, Masayuki T suchiya, Hiroyuki Hirayma
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Publication number: 20250000438Abstract: This information processing device for use in the diagnosis of epilepsy is provided with: a receiving means for receiving the identification of a first site that is a target for the detection of an electric signal in a brain tissue in a subject; a wire information receiving means for receiving wire information; an identification means for identifying a second site that is suitable for the detection of the electric signal from the first site by an epilepsy diagnosis device placed in a blood vessel on the basis of the wire information, in which the blood vessel is selected from blood vessels in the brain tissue in the subject or in a part in the vicinity of the brain tissue; and a display control means for displaying the second site in the blood vessel on a predetermined display unit.Type: ApplicationFiled: October 4, 2022Publication date: January 2, 2025Applicant: Epsilon Medical Inc.Inventors: Yuji MATSUMARU, Hiroki ISHIDA
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Patent number: 12181268Abstract: An optical positioning aid for a distance sensor for assisting in the positioning of the distance sensor relative to a measurement object includes a light source and a control unit. The light source is generates a setting light beam having a wavelength in the visible range and is suitable for generating a light spot on a measurement object. The control unit has a distance input and is communicatively connected to the light source to control at least one property of the setting light beam. The control unit evaluates an input value input into the distance input and influences at least one property of the setting light beam on the basis of a result of the evaluation such that the setting light beam allows conclusions to be drawn concerning the input value. A distance measuring system and a method for assisting in the positioning of a distance sensor are also disclosed.Type: GrantFiled: February 15, 2021Date of Patent: December 31, 2024Assignee: MICRO-EPSILON Optronic GmbHInventors: Torsten Stautmeister, Tobias Schueller, Marco Roessler
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Patent number: 12152086Abstract: The purpose of the present invention is to provide a method for producing a peptide that interacts with a lipid bilayer, and a lipid-bilayer-penetrating peptide obtained through the method. Provided is a lipid-bilayer-penetrating peptide constructed from 10 to 100 amino acids, the peptide having an amino acid sequence that penetrates the lipid bilayer at the C-terminal, and having an amino acid sequence with at least six contiguous arginine at the N-terminal. Also provided is a construct for producing a lipid-bilayer-penetrating peptide, the construct including, from the 5? end toward the 3? end, a tag region 1, a region 1 for incorporating a fluorescent protein gene sequence, a fluorescent protein gene region, a region 2 for incorporating a fluorescent protein gene sequence, a random region, and a stop codon region, and the construct being such that the random region has the aforementioned sequences.Type: GrantFiled: May 7, 2021Date of Patent: November 26, 2024Assignees: Saitama University, Epsilon Molecular Engineering IncorporatedInventors: Naoto Nemoto, Yasuhito Utsugi
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Publication number: 20240324933Abstract: An intravascular device (1) is configured such that a first end section (1a) is disposed in a blood vessel of an organism, and an electrode for detection or stimulation of nerve tissue located outside the blood vessel is provided to the first end section (1a). The intravascular device (1) includes: an electrically-conductive wire member (10); at least one electrode member (20) that is provided on the first end section (1a) side and that is electrically connected to the wire member (10); and difference reduction sections (30, 40) that reduce a level difference caused by an outer diameter difference between the outer diameter of the electrode member (20) and the outer diameter of the wire member (10). The electrical resistance between the electrode member (20) and a second end section (1b) of the wire member (10), which is on the side opposite from the first end section (1a), is 100? or less.Type: ApplicationFiled: October 19, 2023Publication date: October 3, 2024Applicant: Epsilon Medical Inc.Inventors: Hiroki ISHIDA, Yuji MATSUMARU
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Publication number: 20240279618Abstract: A receptor tyrosine kinase agonist which is a single-domain antibody having a cell growth activity, and is at least one receptor tyrosine kinase agonist selected from the group consisting of a human fibroblast growth factor receptor 1 (FGFR1), a human fibroblast growth factor receptor 2 (FGFR2), a human fibroblast growth factor receptor 3 (FGFR3), and a human fibroblast growth factor receptor 4 (FGFR4).Type: ApplicationFiled: June 21, 2022Publication date: August 22, 2024Applicants: SEKISUI CHEMICAL CO., LTD., Epsilon Molecular Engineering, Inc.Inventors: Kenji KASHIWAGI, Teruhiko YANAGISAWA, Ryo YONEHARA, Shigefumi KUMACHI, Kanako NAKAO, Masayuki TSUCHIYA
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Publication number: 20240117012Abstract: Provided is an antibody that binds to the N-protein of SARS-CoV-2, and a method for utilizing the antibody.Type: ApplicationFiled: February 21, 2022Publication date: April 11, 2024Applicants: Kao Corporation, Epsilon Molecular Engineering, Inc.Inventors: Shunsuke INAURA, Yuta MATSUMURA, Takuto TOJO, Atsushi NAGAMI
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Publication number: 20240037558Abstract: The present invention discloses a system for transferring digital assets in a digital transaction and a method thereof.Type: ApplicationFiled: October 6, 2023Publication date: February 1, 2024Applicant: Half Epsilon Pte. Ltd.Inventor: Pralhad Dinesh Deshpande
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Patent number: 11828583Abstract: With regard to a reliable measurement of the thickness of an object (4) even in an environment with high temperatures, a device (1) is provided for determining the thickness of an object (4), more particularly a strip-like or flat object (4), preferably for use in a hot rolling process, having a frame (2) with at least one leg (5, 6), the at least one leg (5, 6) having a sensor (8a, 8b) for the contactless measuring of the distance to the object (4), which device is characterised in that the at least one leg (5, 6) has a structure consisting of a plurality of layers in order to reduce the temperature effect on the frame (2) and/or on the sensor (8a, 8b).Type: GrantFiled: November 6, 2019Date of Patent: November 28, 2023Assignee: MICRO-EPSILON MESSTECHNIK GMBH & CO. KGInventor: Gerhard Kirschner
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Publication number: 20230365659Abstract: A peptide which binds to SARS-CoV-2 and its usage are provided. The peptide which binds to SARS-CoV-2 comprises one or more structural domain comprising CDR3 consisting of an amino acid sequence of any of SEQ ID NOs: 1 to 9 or an amino acid sequence obtained by substituting at least one amino acid in the amino acid sequence with another amino acid.Type: ApplicationFiled: October 1, 2021Publication date: November 16, 2023Applicants: EPSILON MOLECULAR ENGINEERING, INC., THE KITASATO INSTITUTE, Kao CorporationInventors: Hidekazu Masaki, Shigefumi KUMACHI, Ryo YONEHARA, Yuta MATSUMURA, Hibiki KAWANO, Takuto TOJO, Takuya MORIMOTO, Kazunhiko KATAYAMA, Kei HAGA, Reiko TODAKA, Akihito SAWADA, Tomomi TAKANO
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Patent number: 11634705Abstract: The purpose of the present invention is to provide a method for identifying antibody CDR3 clusters using high speed in vitro screening a library selected from the group consisting of cDNA library and nucleic acid aptamer library comprising: (i) preparing a positive spherical shaped structure by binding a target molecule to a spherical shaped molecule, wherein the target molecule is immobilized on the positive spherical shaped structure, wherein the positive spherical shaped structure may contain a fluorescent label; (ii) preparing a negative spherical shaped structure, wherein the target molecule is not immobilized on the negative spherical shaped structure, wherein the negative spherical shaped structure may contain a fluorescent label; (iii) forming a positive spherical shaped conjugate or a negative spherical shaped conjugate by binding a target detecting molecule capable of binding to the target molecule to the positive spherical shaped structure or to the negative spherical structure, wherein the targetType: GrantFiled: September 18, 2020Date of Patent: April 25, 2023Assignee: EPSILON MOLECULAR ENGINEERING INC.Inventors: Naoto Nemoto, Toshiki Miyajima, Yuta Matsukawa
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Patent number: 11614614Abstract: A disclosed reluctance actuator includes a magnetizable stator, at least one coil, and a yoke. The coil is configured to generate a magnetic field in the stator and the yoke is configured to partially close the magnetic flux of the stator. The yoke is further configured as a movable element that performs lifting/tilting movements. An actuator system including a non-magnetic housing and a reluctance actuator is also disclosed. In the actuator system, the reluctance actuator may be at least partially located in the non-magnetic housing. A method of performing lifting/tilting movements of the yoke of a reluctance actuator is also disclosed. The method includes controlling a current in the at least one coil of the reluctance actuator to thereby generate a magnetic field in the stator. The magnetic field generates a lifting/tilting movement of the yoke due to interaction between the magnetic field and the yoke.Type: GrantFiled: February 8, 2018Date of Patent: March 28, 2023Assignee: MICRO-EPSILON MESSTECHNIK GMBH & CO. KGInventors: Georg Schitter, Ernst Csencsics, Johannes Schlarp, Tobias Schopf
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Patent number: 11498815Abstract: A crane control for a crane includes at least one operating unit operable by an operator for controlling working functions of the crane. Control signals can be input to actuators of the crane by the operating unit, and a mounting arrangement is provided for mounting the operating unit in a driving cab of the vehicle and a support arrangement connects the operating unit to the mounting arrangement. The support arrangement for the operating unit is supported limitedly moveably between at least two positions, a first position of which is in the form of a working position in which the operating unit is between a steering arrangement of the vehicle and a driving seat, and a second position of which is in the form of a storage position in which the operating unit is moved away from the steering arrangement of the vehicle.Type: GrantFiled: July 12, 2019Date of Patent: November 15, 2022Assignee: EPSILON Kran GmbHInventors: Simon Schoerghofer, Johannes Steindl
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Patent number: 11333481Abstract: 1. A device for the contactless distance and/or position determination of a measurement object (1), with an electrically conductive measurement object (1) and with a sensor (3) operating in particular according to the inductive, capacitive or the eddy current principle, wherein the sensor (3) comprises a measurement device (4), characterized in that the measurement device (4) is formed by at least two measurement elements (5, 5?, 5?) which are spatially separated from each other. Moreover, a corresponding sensor (3) is indicated.Type: GrantFiled: August 12, 2016Date of Patent: May 17, 2022Assignee: MICRO-EPSILON MESSTECHNIK GMBH & CO. KGInventors: Reinhold Hoenicka, Tobias Schopf, Jakob Stieß
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Patent number: 11313664Abstract: The present invention relates to a measuring device for determining the thickness of a dielectric layer on a conductive substrate. The device comprises a resonance cavity for electromagnetic fields which has a rotationally symmetrical wall, an end plate and an open end and is adapted to be positioned with the open end on the dielectric layer. The device further comprises an antenna which is adapted to excite an electro-magnetic field in the resonance cavity, a reflection measuring unit for determining at least one property of the electromagnetic field and an evaluation circuit for determining the thickness of the dielectric layer from the at least one property of the electromagnetic field. A diameter of the rotationally symmetrical wall varies in a longitudinal direction of the resonance cavity.Type: GrantFiled: August 14, 2018Date of Patent: April 26, 2022Assignee: MICRO-EPSILON Messtechnik GmbH & Co. KGInventors: Christian Ziep, Maik Richter, Johann Hinken
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Patent number: 11198391Abstract: A crane control for a crane includes a visualization apparatus which is adapted to generate a stereoscopically visualized camera image having depth information of a working environment of the crane for an operator of the crane control. The visualization apparatus is configured to generate in a representation overlying the camera image a graphic auxiliary representation representing a dimension which can be recognized per se in the camera image. Furthermore, the visualization apparatus includes a display device which displays the stereoscopically visualized camera image together with the overlying graphic auxiliary representation.Type: GrantFiled: July 12, 2019Date of Patent: December 14, 2021Assignee: EPSILON Kran GmbHInventors: Josef Leitner, Martin Galler
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Publication number: 20210381026Abstract: The present invention provides an improved immuno-PCR method by using cDNA display comprising the steps of: immobilizing a first antibody having a binding site to a solid phase: contacting a sample fluid to said antibody to bind a target molecule in said sample fluid; contacting said target molecule to a cDNA display being composed of a backbone being composed of a double strand and a side chain having a second antigen binding site to which the second antibody is bound; and conducting polymerase chain reaction to detect said cDNA quantitatively. According to the improved immune-PCR method of the present invention, the target molecule is screened and obtained quantitatively, because it uses cDNA display being composed of one protein/peptide and one DNA.Type: ApplicationFiled: August 21, 2021Publication date: December 9, 2021Applicants: EPSILON MOLECULAR ENGINEERING INC., Saitama UniversityInventors: Naoto Nemoto, Hironori Anzai, Takeru Suzuki, Shigefumi Kumachi, Takuya Terai
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Patent number: 11125550Abstract: A method of optically measuring a surface of a measurement object is disclosed. The method includes generating image light having an image pattern, projecting the generated image light onto the measurement object, and recording influenced light having an influenced image pattern. The image light is generated by an image generation device and the influenced light is captured by a capturing device. The influenced light is light that is reflected, scattered, diffracted, and/or transmitted by the measurement object based on interaction of the image light with the measurement object. The method further includes applying a correcting function to the image light. The correction function alters the image light such that the influenced image pattern recorded by the capturing device shows temporally and/or locally an at least approximately constant and/or homogenous and/or linear brightness. A device having an image generation device, image capture device, and correcting device is also disclosed.Type: GrantFiled: May 18, 2018Date of Patent: September 21, 2021Assignee: MICRO-EPSILON MESSTECHNIK GMBH & CO. KGInventors: Hannes Loferer, Reiner Kickingereder, Josef Reitberger, Rainer Hesse, Robert Wagner
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Patent number: 11110701Abstract: A main body of doctor blade chambers including a first portion configured to hold a first doctor blade, a second portion configured to hold a second doctor blade, a third portion connecting the first portion and the second portion, a cavity intended to receive ink and defined at least by the first portion, the second portion and the third portion, characterized in that the main body is a single closed hollow profile extending along a longitudinal main axis X-X, the main body being made of pultruded composite material.Type: GrantFiled: July 6, 2018Date of Patent: September 7, 2021Assignees: BOBST LYON, EPSILON COMPOSITEInventors: René Bazin, Philippe Fleury, Julien Mattrand, Steve Peter Daniel Willems