Abstract: Systems and methods for managing illness outside of a hospital environment are provided. A plurality of alert generation definitions is stored with each of the definitions defining at least one condition for generating an alert. A patient profile data structure for a patient is generated which includes indicators of characteristics of the patient. Monitoring data is received, which reflects at least one of (i) physiological indicators of the patient; and (ii) indicators of medical supplies being ordered or consumed by the patient. An alert relating to patient healthcare is generated by applying at least one of the alert generation definitions to the received monitoring data. Population data reflective of healthcare outcomes for a patient population is received. At least one further alert generation definition is generated upon processing the population data, and the at least one further alert generation definition is stored.